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    v1.0.30
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j0131-injection-acetaminophen-10mg-parenteral-analgesic
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    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS Level II code J0131 describes an injectable formulation of acetaminophen, not otherwise specified, 10 mg, intended for parenteral administration; the service is an injection typically provided in outpatient clinics, hospital settings, or infusion centers for analgesia or antipyresis when IV/IM delivery is required.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult presenting to an outpatient infusion center or emergency department with acute severe pain or when oral acetaminophen is contraindicated or ineffective (for example, post-operative pain, acute musculoskeletal injury, or severe headache where oral intake is not feasible). The clinician (an emergency physician, anesthesiologist, hospitalist, or infusion nurse under physician order) verifies medication allergies, calculates dose based on indication and milligram strength, prepares the intravenous or intramuscular J0131 product, documents informed consent when required, and administers the injection. Vital signs and pain scores are monitored before and after administration. The encounter may include evaluation and management, procedural analgesia, or adjunctive therapies; medication administration is documented in the medication administration record, including lot number, route, dose, and time. Billing uses HCPCS Level II code J0131 for the supplied injected acetaminophen product (10 mg unit), with appropriate modifiers to indicate service circumstances and any related professional services.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96365Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hourBilled when the acetaminophen injection is part of an infusion service lasting up to one hour or when IV infusion setup/time-based services are provided.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularBilled for the actual administration of a single injection when a separate administration code is required in addition to the drug HCPCS code.
    99283Emergency department visit for the evaluation and management of a patient, typically 30 minutesMay be billed when an emergency department E/M service is provided in addition to the injectable medication.
    01990Intraoperative medication, not otherwise specified (specify)Billed when anesthesiology or surgical team documents intraoperative administration of parenteral analgesic as part of anesthesia services.
    99199Unlisted anesthesia procedureUsed when a specific anesthesia-related billing for an unusual administration circumstance is required alongside the drug supply code.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    208000000X
    363A00000X
    207L00000X
    207R00000X
    207RI0011X
    2279P1006X
    156FX1201X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    G43.709Chronic migraine without aura, not intractable, without status migrainosus
    G89.3Neoplasm related pain (acute) (chronic)
    G89.4Chronic pain syndrome
    K52.9Noninfective gastroenteritis and colitis, unspecified
    K57.30Diverticulosis of large intestine without perforation or abscess without bleeding
    M25.50Pain in unspecified joint
    M25.561Pain in right knee
    M25.562Pain in left knee
    M47.817Spondylosis without myelopathy or radiculopathy, lumbosacral region
    M51.26Other intervertebral disc displacement, lumbar region

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    HCPCS-J0135-ADALIMUMAB-20MG-INJECTION

    HCPCS Level II J0135: Injection, adalimumab, 20 mg

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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