HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS Level II code J0131 describes an injectable formulation of acetaminophen, not otherwise specified, 10 mg, intended for parenteral administration; the service is an injection typically provided in outpatient clinics, hospital settings, or infusion centers for analgesia or antipyresis when IV/IM delivery is required.

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HCPCS Level II J0131: Injection, Acetaminophen 10 mg

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Get alerted when payer policies referencing J0131 are released or updated.

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Clinical & Coding Specifications

Clinical Context

A typical patient is an adult presenting to an outpatient infusion center or emergency department with acute severe pain or when oral acetaminophen is contraindicated or ineffective (for example, post-operative pain, acute musculoskeletal injury, or severe headache where oral intake is not feasible). The clinician (an emergency physician, anesthesiologist, hospitalist, or infusion nurse under physician order) verifies medication allergies, calculates dose based on indication and milligram strength, prepares the intravenous or intramuscular J0131 product, documents informed consent when required, and administers the injection. Vital signs and pain scores are monitored before and after administration. The encounter may include evaluation and management, procedural analgesia, or adjunctive therapies; medication administration is documented in the medication administration record, including lot number, route, dose, and time. Billing uses HCPCS Level II code J0131 for the supplied injected acetaminophen product (10 mg unit), with appropriate modifiers to indicate service circumstances and any related professional services.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96365`	Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour	Billed when the acetaminophen injection is part of an infusion service lasting up to one hour or when IV infusion setup/time-based services are provided.
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Billed for the actual administration of a single injection when a separate administration code is required in addition to the drug HCPCS code.
`99283`	Emergency department visit for the evaluation and management of a patient, typically 30 minutes	May be billed when an emergency department E/M service is provided in addition to the injectable medication.
`01990`	Intraoperative medication, not otherwise specified (specify)	Billed when anesthesiology or surgical team documents intraoperative administration of parenteral analgesic as part of anesthesia services.
`99199`	Unlisted anesthesia procedure	Used when a specific anesthesia-related billing for an unusual administration circumstance is required alongside the drug supply code.

Related Modifiers

5 rows

Modifier	Description	When to Use
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
25	CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…	- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207P00000X	Emergency Medicine Physician	An emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
207R00000X	Internal Medicine Physician	A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
207RI0011X	Interventional Cardiology Physician	An area of medicine within the subspecialty of cardiology, which uses specialized imaging and other diagnostic techniques to evaluate blood flow and p…
2279P1006X	Pulmonary Function Technologist Registered Respiratory Therapist	An individual who is trained and qualified to perform pulmonary diagnostic tests. In the course of conducting these tests, the Pulmonary Function Tec…
156FX1201X	Optometric Assistant Technician	An optometric assistant assists optometrists by performing duties, including but not limited to, customer service, basic eye testing, and patient educ…

Related ICD-10-CM Codes

26 rows

ICD-10-CM Code	Description
G43.709	Chronic migraine without aura, not intractable, without status migrainosus
G89.3	Neoplasm related pain (acute) (chronic)
G89.4	Chronic pain syndrome
K52.9	Noninfective gastroenteritis and colitis, unspecified
K57.30	Diverticulosis of large intestine without perforation or abscess without bleeding
M25.50	Pain in unspecified joint
M25.561	Pain in right knee
M25.562	Pain in left knee
M47.817	Spondylosis without myelopathy or radiculopathy, lumbosacral region
M51.26	Other intervertebral disc displacement, lumbar region

Showing 1–10 of 26

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

HCPCS-J0135-ADALIMUMAB-20MG-INJECTION

HCPCS Level II J0135: Injection, adalimumab, 20 mg

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96365`	Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour	Billed when the acetaminophen injection is part of an infusion service lasting up to one hour or when IV infusion setup/time-based services are provided.
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Billed for the actual administration of a single injection when a separate administration code is required in addition to the drug HCPCS code.
`99283`	Emergency department visit for the evaluation and management of a patient, typically 30 minutes	May be billed when an emergency department E/M service is provided in addition to the injectable medication.
`01990`	Intraoperative medication, not otherwise specified (specify)	Billed when anesthesiology or surgical team documents intraoperative administration of parenteral analgesic as part of anesthesia services.
`99199`	Unlisted anesthesia procedure	Used when a specific anesthesia-related billing for an unusual administration circumstance is required alongside the drug supply code.

Related Modifiers

5 rows

Modifier	Description	When to Use
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
25	CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…	- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207P00000X	Emergency Medicine Physician	An emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
207R00000X	Internal Medicine Physician	A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
207RI0011X	Interventional Cardiology Physician	An area of medicine within the subspecialty of cardiology, which uses specialized imaging and other diagnostic techniques to evaluate blood flow and p…
2279P1006X	Pulmonary Function Technologist Registered Respiratory Therapist	An individual who is trained and qualified to perform pulmonary diagnostic tests. In the course of conducting these tests, the Pulmonary Function Tec…
156FX1201X	Optometric Assistant Technician	An optometric assistant assists optometrists by performing duties, including but not limited to, customer service, basic eye testing, and patient educ…

Related ICD-10-CM Codes

26 rows

ICD-10-CM Code	Description
G43.709	Chronic migraine without aura, not intractable, without status migrainosus
G89.3	Neoplasm related pain (acute) (chronic)
G89.4	Chronic pain syndrome
K52.9	Noninfective gastroenteritis and colitis, unspecified
K57.30	Diverticulosis of large intestine without perforation or abscess without bleeding
M25.50	Pain in unspecified joint
M25.561	Pain in right knee
M25.562	Pain in left knee
M47.817	Spondylosis without myelopathy or radiculopathy, lumbosacral region
M51.26	Other intervertebral disc displacement, lumbar region

Showing 1–10 of 26

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

HCPCS-J0135-ADALIMUMAB-20MG-INJECTION

HCPCS Level II J0135: Injection, adalimumab, 20 mg

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

Sign up for hcpcs J0131 policy alerts

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

Sign up for hcpcs J0131 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J0131 represent and where is it typically used?

Which modifiers are relevant for billing J0131 and when are they used?

What CPT or other codes are commonly billed alongside J0131?

In what clinical situations is injectable acetaminophen (J0131) typically administered and what documentation is described?

Which payers are referenced for J0131 coverage and are payer-specific reimbursement details provided?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J0131 represent and where is it typically used?

Which modifiers are relevant for billing J0131 and when are they used?

What CPT or other codes are commonly billed alongside J0131?

In what clinical situations is injectable acetaminophen (J0131) typically administered and what documentation is described?

Which payers are referenced for J0131 coverage and are payer-specific reimbursement details provided?

References