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    v1.0.30
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j0135-adalimumab-20mg-injection
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    HCPCS Level II J0135: Injection, adalimumab, 20 mg

    HCPCS Level II code J0135 denotes a billed administration unit for adalimumab 20 mg supplied as an injection; the service represents provision of the biologic medication for subcutaneous or clinician-administered therapy and is typically billed for drug administration in outpatient infusion clinics, physician offices, or ambulatory care settings where injected biologic therapies are provided.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult with an immune‑mediated inflammatory disease such as moderate to severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn disease, or hidradenitis suppurativa who presents to an outpatient infusion/injection clinic, specialty pharmacy clinic, or physician office for administration of a prefilled syringe of adalimumab. The clinical workflow begins with verification of the prescription and prior authorization, medication reconciliation and allergy check, assessment of baseline vital signs and infection risk screening (including tuberculosis and recent infections), patient education on expected effects and adverse reactions, and documentation of lot number and expiration. The medication J0135 (injection, adalimumab, 20 mg) is obtained from pharmacy, labeled, and administered subcutaneously by a registered nurse or licensed medical personnel. Observation for acute hypersensitivity or injection‑site reaction occurs for a short period (typically 15–30 minutes) after injection. Documentation includes indication, medication name and dose, route, site, lot number, NDC when required, and any immediate adverse events. Billing includes the HCPCS Level II code J0135 and may include relevant modifiers for unusual circumstances or payer requirements.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularCommonly used to report the administration service for a subcutaneous injection like adalimumab when payer requires a separate administration code in addition to the drug HCPCS J0135.
    99001Handling and/or processing of a drug or biological for patient administration, per dose (example placeholder — verify payer list)Some facilities use specific facility or local codes for drug handling; verify payer policy. (Note: use only if recognized by the payer.)
    96360Intravenous infusion, hydration; initial, 31 minutes to 1 hourNot typical for subcutaneous adalimumab but included when an infusion encounter with separate infusion services occurs concurrently.
    36415Collection of venous blood by venipunctureOften performed prior to biologic initiation for baseline labs (CBC, CMP, TB testing) supporting therapy with adalimumab.
    99406Smoking and tobacco use cessation counseling visit, intermediateCounseling codes commonly used during chronic disease management visits where lifestyle counseling is provided alongside biologic therapy.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    208000000X
    207L00000X
    363LF0000X
    367A00000X
    152WC0802X
    246ZC0007X
    225B00000X

    Related ICD-10-CM Codes

    20 rows

    ICD-10-CM CodeDescription
    B18.2Chronic viral hepatitis C
    C50.919Malignant neoplasm of unspecified site of unspecified female breast
    D86.9Sarcoidosis, unspecified
    E11.9Type 2 diabetes mellitus without complications
    H40.9Unspecified glaucoma
    K50.90Crohn's disease, unspecified, without complications
    K51.90Ulcerative colitis, unspecified, without complications
    L40.0Psoriasis vulgaris
    L40.54Psoriatic juvenile arthropathy
    M05.79Rheumatoid arthritis with rheumatoid factor of multiple sites without organ or systems involvement

    Showing 1–10 of 20

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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