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    v1.0.30
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j0132-injection-acetylcysteine-100mg-injectable-medication
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    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS Level II code J0132 describes an injection of acetylcysteine, 100 mg, typically administered as a medication infusion or injectable therapy in outpatient infusion centers, emergency departments, or inpatient hospital settings for indications requiring mucolytic or antidote therapy; the code is used on medical claims to represent each 100 mg unit of acetylcysteine supplied and billed by the provider.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult presenting to an emergency department or infusion center with documented or suspected acetaminophen (paracetamol) overdose. The patient has either a known ingestion time within 24 hours or presents with elevated transaminases and a toxicology evaluation indicating significant risk of hepatic injury. After triage and initial assessment (vital signs, airway/breathing/circulation stabilization), serum acetaminophen level is obtained and plotted on the Rumack–Matthew nomogram when applicable. If the measured level is above the treatment threshold or if ingestion timing is uncertain with clinical concern for hepatotoxicity, intravenous N-acetylcysteine is ordered. Pharmacy prepares J0132 (Injection, acetylcysteine, 100 mg) in appropriate concentration and volume. Nursing administers the infusion per hospital protocol (loading dose followed by maintenance infusions) with continuous monitoring for anaphylactoid reactions, vital sign changes, and response to therapy. Laboratory monitoring (liver function tests, INR, electrolytes) is performed serially during and after therapy. Discharge or admission decisions are based on clinical course, lab trends, and completion of the NAC protocol.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96365Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hourOften used for billing infusion time for the initial NAC loading infusion when billed separately.
    96366Intravenous infusion, each additional hour (List separately in addition to code for primary infusion)Used for subsequent hourly infusion time for maintenance NAC dosing when time-based infusion billing is appropriate.
    36415Collection of venous blood by venipuncturePerformed for baseline and serial labs (acetaminophen level, LFTs, INR, electrolytes) during NAC therapy.
    84460Assay of acetaminophen; quantitativeDirectly related diagnostic test that informs the decision to initiate and continue NAC therapy.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularMay be used if NAC is administered intramuscularly in a specific protocol (intravenous administration is typical for J0132).

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    207RH0000X
    363LF0000X
    364S00000X
    2085N0904X
    133N00000X
    2085B0100X
    1835C0205X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    E86.0Dehydration
    E86.1Hypovolemia
    F10.120Alcohol abuse with intoxication, uncomplicated
    F10.129Alcohol abuse with intoxication, unspecified
    F11.120Opioid abuse with intoxication, uncomplicated
    F19.120Other psychoactive substance abuse with intoxication, uncomplicated
    J44.1Chronic obstructive pulmonary disease with (acute) exacerbation
    J45.901Unspecified asthma with (acute) exacerbation
    J96.00Acute respiratory failure, unspecified whether with hypoxia or hypercapnia
    J96.01Acute respiratory failure with hypoxia

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    HCPCS-J0135-ADALIMUMAB-20MG-INJECTION

    HCPCS Level II J0135: Injection, adalimumab, 20 mg

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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