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    v1.0.30
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j0122-eravacycline-injection-1mg
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    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS Level II code J0122 represents the billed service for an injection of eravacycline, 1 mg, a systemic intravenous antibiotic formulation used for treatment of serious bacterial infections; the service type is drug administration (injectable pharmacologic agent) and the typical site of service is hospital inpatient or outpatient infusion/IV therapy setting where parenteral antibiotics are administered.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult hospitalized for a complicated intra-abdominal or severe community-acquired bacterial infection who requires intravenous broad-spectrum therapy. Eravacycline is administered as an intravenous infusion prepared from the J0122 billing unit (injection, eravacycline, 1 mg). The clinical workflow begins with infectious disease consultation and selection of eravacycline when pathogens or clinical risk factors (multidrug-resistant Gram-negative organisms, prior antibiotic exposure, or intolerance to other agents) warrant its use. Pharmacy compounds the exact dose based on patient weight and renal/hepatic status, labels the vial(s), and documents lot numbers. Nursing verifies the order, obtains intravenous access (peripheral or central), performs bedside time-out, and administers the infusion per institutional protocol (typically over 60 minutes depending on preparation). Post-infusion monitoring includes vital signs, assessment for infusion reactions, and documentation of dose, units administered (milligrams via J0122), and any adverse events. Billing captures J0122 units corresponding to the milligrams administered, with applicable modifiers for circumstances such as professional service, administration complexity, or discarded medication per standards.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96365Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hourCommonly billed for the administration time of the first-hour eravacycline infusion in an outpatient infusion center or clinic.
    96366Intravenous infusion, each additional hour (List separately in addition to code for primary infusion)Billed when eravacycline infusion exceeds one hour or for prolonged infusion or observation time.
    36415Collection of venous blood by venipuncturePerformed prior to or during therapy for baseline labs, therapeutic drug monitoring, or culture draws.
    36556Insertion of non-tunneled centrally inserted central venous catheter; age 5 years or olderPerformed if central access is required for prolonged or vesicant therapy related to administration.
    99070Supplies and materials (except spectacles), noncovered items or services; used by providerBilled for additional disposable supplies used during infusion when payers allow separate supply charges.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    363L00000X
    364S00000X
    2085H0002X
    207QD0401X
    177F00000X
    133VN1401X
    163WC1600X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    A02.1Salmonella sepsis
    A03.0Shigellosis due to Shigella dysenteriae
    A30.0Indeterminate leprosy
    A35Other tetanus
    A39.0Meningococcal meningitis
    A40.0Sepsis due to streptococcus, group A
    A41.51Sepsis due to Escherichia coli [E. coli]
    A41.52Sepsis due to Pseudomonas
    A41.9Sepsis, unspecified organism
    A43.9Nocardiosis, unspecified

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    HCPCS-J0135-ADALIMUMAB-20MG-INJECTION

    HCPCS Level II J0135: Injection, adalimumab, 20 mg

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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