CPT 81448: Peripheral Neuropathy Gene Panel, Sequencing
Commercial payers pay $586 on average nationally for this procedure.
CPT code 81448 describes a genomic sequence analysis panel performed by a laboratory analyst to evaluate a patient specimen for genetic sequences of at least five peripheral neuropathy–related genes; this service is a molecular diagnostic genomic sequencing panel typically performed as a laboratory pathology molecular test with the typical site of service being an outpatient clinical laboratory or hospital laboratory setting.
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National Reimbursement Benchmarks
Commercial rates for CPT 81448 cluster around an average commercial (BUCA) mean of $586.20, with substantial variation across major carriers. Blue Cross Blue Shield shows the highest mean and a wide spread, while Aetna’s distribution is tighter and centered lower. Cigna and UnitedHealth Group both exhibit notable dispersion, and BUCA’s quartiles indicate that a typical commercial contract often lands in the mid-$300s to high-$600s range.
Comparing interquartile ranges (P75 minus P25) highlights dispersion: Blue Cross Blue Shield’s IQR is $304.20, Cigna’s IQR is $424.10, UnitedHealth Group’s IQR is $317.20, Aetna’s IQR is $181.40, and BUCA’s IQR is $326.00. Cigna has the widest IQR, indicating the greatest middle-50% variability, while Aetna is the tightest, showing the most concentrated commercial pricing among the listed payers.