CPT 81411: Genetic Panel for Aortic Dysfunction Copy Number Analysis
Commercial payers pay $1347 on average nationally for this procedure.
CPT code 81411 describes a molecular pathology panel performed by a laboratory analyst to detect duplications and deletions involving at least four specified genes associated with aortic dysfunction or dilation; the service is a genetic diagnostic test typically performed on patient specimens in a clinical molecular diagnostics laboratory or specialized genetics testing facility.
For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.
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National Reimbursement Benchmarks
National commercial rates for CPT 81411 cluster around BUCA’s average commercial benchmark of $1,347.20, with Blue Cross Blue Shield and Cigna above that midpoint and UnitedHealth Group and Aetna lower on average. Blue Cross Blue Shield shows the highest median ($1,318.10) and a very large upper tail (max $8,312.30), while Aetna’s distribution centers lower (median $728.00) with a zero minimum noted in its inputs.
Dispersion measured by the interquartile spread (P75 minus P25) is widest for Cigna and Blue Cross Blue Shield at $1,037.90 and $502.00 respectively, indicating greater variability in contracted commercial payments; UnitedHealth Group is intermediate with a spread of $783.10. Aetna has the tightest IQR at $414.50, suggesting relatively constrained variation among its middle 50% of rates.