CPT 81414: Cardiac Ion Channelopathy Copy Number Variant Panel
Commercial payers pay $592 on average nationally for this procedure.
CPT code 81414 describes a laboratory panel that detects genetic duplications and deletions (copy number variants) involving at least two genes associated with cardiac ion channelopathies, performed by a clinical laboratory or pathology service; this is a molecular diagnostic genetic test typically provided as a send-out or reference laboratory service with specimen collection and testing performed in an outpatient laboratory or specialized molecular diagnostic facility.
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National Reimbursement Benchmarks
National commercial reimbursement for CPT 81414 centers on a BUCA (average commercial) rate of $592.30, with payer-specific means clustering above and below that mark. Blue Cross Blue Shield’s mean of $676 and Cigna’s mean of $605.20 sit near BUCA, while Aetna’s mean of $417.50 and UnitedHealth Group’s mean of $503 are lower. Blue Cross Blue Shield and Cigna display high upper tails, with maximums of $2345.50 and $1901.60 respectively, whereas Aetna’s maximum is comparatively modest at $758.
Dispersion measured by the interquartile range (P75–P25) highlights variability: Blue Cross Blue Shield’s IQR is $260.00 (from $472.70 to $756.70), Cigna’s IQR is $447.70 (from $343.90 to $786.60), UnitedHealth Group’s IQR is $321.60 (from $256.30 to $584.90), BUCA’s IQR is $287.00 (from $380.70 to $694.70), and Aetna’s IQR is $300.40 (from $266.00 to $526.40). Cigna shows the widest IQR at $447.70, indicating the greatest middle-50% spread, while Blue Cross Blue Shield’s narrower IQR at $284.00 indicates the tightest middle-range among the listed payers.