ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group XW05 includes procedures performed to introduce therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into peripheral arteries. These ICD-10-PCS codes are used for inpatient documentation when a substance is deliberately delivered into a peripheral arterial site for treatment, diagnosis, or support. Accurate coding within the ICD-10-PCS XW05 group is essential for proper inpatient reimbursement, as it captures the specific introduction procedure performed and supports clinical documentation accuracy.

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Peripheral Artery Introduction Procedure Overview

Procedures in this group involve the introduction of therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into peripheral arteries. These procedures target anatomical regions supplied by peripheral arteries and typically use catheter-based or percutaneous techniques to deliver substances. Accurate ICD-10-PCS coding of these introductions matters for inpatient reimbursement because it documents the specific arterial site and the introduction operation, which affects case mix and payment.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
X	Section	New Technology
W	Body System	Anatomical Regions
0	Operation	Introduction
5	Body Part	Peripheral Artery

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ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

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Peripheral Artery Introduction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
X	Section	New Technology
W	Body System	Anatomical Regions
0	Operation	Introduction
5	Body Part	Peripheral Artery

When to Use

Use a code from this group when a clinician deliberately delivers a substance into a peripheral artery during an inpatient encounter, such as for regional drug delivery, diagnostic contrast administration, or physiologic support. Select the code that matches the specific peripheral arterial site and the introduction operation documented in the clinical record.

ICD-10-PCS Codes

2 rows

ICD-10-PCS Code	Description
XW0534B	Introduction of Somatic Stem Cells into Peripheral Artery, Percutaneous Approach, New Technology Group 11
XW053T9	Introduction of Melphalan Hydrochloride Antineoplastic into Peripheral Artery, Percutaneous Approach, New Technology Group 9

Typical Clinical Scenarios

An adult patient is admitted from the emergency department with acute limb-threatening ischemia of the lower extremity due to an embolus. Interventional radiology performs a percutaneous arterial catheterization to deliver thrombolytic medication directly into the affected peripheral artery to restore perfusion and salvage the limb. The targeted introduction into a peripheral artery is documented as the therapeutic delivery route. Typical codes: XW053T9
A middle-aged patient with recurrent hepatic metastases is admitted for a planned regional chemotherapy infusion. The oncology team places a percutaneous catheter to introduce melphalan hydrochloride directly into a peripheral arterial access site that supplies the limb or region as part of isolated regional perfusion therapy. The procedure is performed electively to concentrate antineoplastic therapy regionally while minimizing systemic exposure. Typical codes: XW053T9
A patient previously treated with percutaneous arterial infusion of chemotherapy presents with inadequate regional response, and the team opts for delivery of investigational somatic stem cells into the peripheral arterial circulation to promote local tissue regeneration. A percutaneous introduction into the peripheral artery is performed during this inpatient admission as a revision or subsequent therapeutic attempt after prior interventions. Typical codes: XW0534B

Related Codes

XW00-SKIN-INTRODUCTION

ICD-10-PCS Code For Skin: Procedure Code Group Overview

XW01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

XW02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

XW03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

XW04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

XW06-CEREBRAL-VENTRICLE-INTRODUCTION

ICD-10-PCS Code For Cerebral Ventricle: Procedure Code Group Overview

XW0D-MOUTH-AND-PHARYNX-INTRODUCTION

ICD-10-PCS Code For Mouth And Pharynx: Procedure Code Group Overview

XW0E-EAR-INTRODUCTION-EAR-S-INTRODUCTION

ICD-10-PCS Code For Ear(s): Procedure Code Group Overview

XW0G-UPPER-GI-INTRODUCTION

ICD-10-PCS Code For Upper Gi: Procedure Code Group Overview

XW0H-LOWER-GI-INTRODUCTION

ICD-10-PCS Code For Lower GI: Procedure Code Group Overview

Showing 1–10 of 17

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

2 rows

ICD-10-PCS Code	Description
XW0534B	Introduction of Somatic Stem Cells into Peripheral Artery, Percutaneous Approach, New Technology Group 11
XW053T9	Introduction of Melphalan Hydrochloride Antineoplastic into Peripheral Artery, Percutaneous Approach, New Technology Group 9

Typical Clinical Scenarios

An adult patient is admitted from the emergency department with acute limb-threatening ischemia of the lower extremity due to an embolus. Interventional radiology performs a percutaneous arterial catheterization to deliver thrombolytic medication directly into the affected peripheral artery to restore perfusion and salvage the limb. The targeted introduction into a peripheral artery is documented as the therapeutic delivery route. Typical codes: XW053T9
A middle-aged patient with recurrent hepatic metastases is admitted for a planned regional chemotherapy infusion. The oncology team places a percutaneous catheter to introduce melphalan hydrochloride directly into a peripheral arterial access site that supplies the limb or region as part of isolated regional perfusion therapy. The procedure is performed electively to concentrate antineoplastic therapy regionally while minimizing systemic exposure. Typical codes: XW053T9
A patient previously treated with percutaneous arterial infusion of chemotherapy presents with inadequate regional response, and the team opts for delivery of investigational somatic stem cells into the peripheral arterial circulation to promote local tissue regeneration. A percutaneous introduction into the peripheral artery is performed during this inpatient admission as a revision or subsequent therapeutic attempt after prior interventions. Typical codes: XW0534B

Related Codes

XW00-SKIN-INTRODUCTION

ICD-10-PCS Code For Skin: Procedure Code Group Overview

XW01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

XW02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

XW03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

XW04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

XW06-CEREBRAL-VENTRICLE-INTRODUCTION

ICD-10-PCS Code For Cerebral Ventricle: Procedure Code Group Overview

XW0D-MOUTH-AND-PHARYNX-INTRODUCTION

ICD-10-PCS Code For Mouth And Pharynx: Procedure Code Group Overview

XW0E-EAR-INTRODUCTION-EAR-S-INTRODUCTION

ICD-10-PCS Code For Ear(s): Procedure Code Group Overview

XW0G-UPPER-GI-INTRODUCTION

ICD-10-PCS Code For Upper Gi: Procedure Code Group Overview

XW0H-LOWER-GI-INTRODUCTION

ICD-10-PCS Code For Lower GI: Procedure Code Group Overview

Showing 1–10 of 17

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview policy alerts

Peripheral Artery Introduction Procedure Overview

Code Attributes

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview policy alerts

Peripheral Artery Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

What types of substances are introduced under the ICD-10-PCS XW05 code group?

Which approach is used for the listed codes in this group?

How does accurate coding within XW05 affect inpatient reimbursement?

What are the example codes included in the XW05 group?

Which ICD-10-PCS section and body system describe these procedures?

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

What types of substances are introduced under the ICD-10-PCS XW05 code group?

Which approach is used for the listed codes in this group?

How does accurate coding within XW05 affect inpatient reimbursement?

What are the example codes included in the XW05 group?

Which ICD-10-PCS section and body system describe these procedures?

References