ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group XW04 includes procedures performed to introduce therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into central veins. These ICD-10-PCS codes are used for inpatient documentation when a central venous access is established to deliver substances other than blood or blood products. Accurate coding within the ICD-10-PCS XW04 group is essential for proper inpatient reimbursement, as it captures the procedure performed and determines appropriate case mix and payment.

Customize your policy alerts

Sign up for ICD-10-PCS Code For Central Vein: Procedure Code Group Overview policy alerts

Get alerted when relevant policies change without checking for updates manually.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Central Vein Introduction Procedure Overview

This procedure group includes inpatient introduction procedures performed on central veins, involving the insertion of therapeutic, diagnostic, nutritional, physiological, or prophylactic substances except blood or blood products into a central venous location. These procedures target central venous anatomy and typically involve vascular access devices or catheters placed into central veins. Accurate coding of these introductions is important for inpatient reimbursement because it documents the anatomical site and operation performed, which affects case mix and payment determination.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
X	Section	New Technology
W	Body System	Anatomical Regions
0	Operation	Introduction
4	Body Part	Central Vein

Explore openpayer tools

View all tools

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

Customize your policy alerts

Sign up for ICD-10-PCS Code For Central Vein: Procedure Code Group Overview policy alerts

Get alerted when relevant policies change without checking for updates manually.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Central Vein Introduction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
X	Section	New Technology
W	Body System	Anatomical Regions
0	Operation	Introduction
4	Body Part	Central Vein

When to Use

Use a code from this group when a substance is delivered into a central vein through an introduced device during an inpatient stay. Codes are selected when documentation specifies introduction into a central venous location rather than peripheral venous access or other sites.

ICD-10-PCS Codes

55 rows

ICD-10-PCS Code	Description
XW04308	Introduction of Spesolimab Monoclonal Antibody into Central Vein, Percutaneous Approach, New Technology Group 8
XW0430B	Introduction of Alpha1-proteinase Inhibitor into Central Vein, Percutaneous Approach, New Technology Group 11
XW0431B	Introduction of Anitocabtagene Autoleucel Immunotherapy into Central Vein, Percutaneous Approach, New Technology Group 11
XW0433A	Introduction of Bentracimab, Ticagrelor Reversal Agent into Central Vein, Percutaneous Approach, New Technology Group 10
XW0434A	Introduction of Cefepime-taniborbactam Anti-infective into Central Vein, Percutaneous Approach, New Technology Group 10
XW04357	Introduction of Narsoplimab Monoclonal Antibody into Central Vein, Percutaneous Approach, New Technology Group 7
XW04358	Introduction of Mosunetuzumab Antineoplastic into Central Vein, Percutaneous Approach, New Technology Group 8
XW0435A	Introduction of Ceftobiprole Medocaril Anti-infective into Central Vein, Percutaneous Approach, New Technology Group 10
XW04367	Introduction of Terlipressin into Central Vein, Percutaneous Approach, New Technology Group 7
XW04368	Introduction of Afamitresgene Autoleucel Immunotherapy into Central Vein, Percutaneous Approach, New Technology Group 8

Showing 1–10 of 55

DRG Codes

1 rows

DRG Code	Description
018	Chimeric Antigen Receptor (CAR) T-Cell and Other Immunotherapies

Typical Clinical Scenarios

An adult patient with relapsed refractory diffuse large B-cell lymphoma is admitted for inpatient administration of a novel bispecific antineoplastic infusion requiring central venous access for delivery because peripheral access is inadequate and the agent is vesicant/potent. The patient receives a percutaneous central line placement and the targeted antineoplastic agent is introduced into the central vein during the admission to ensure controlled dosing and monitoring for cytokine release. The procedure documents introduction into a central venous location. Typical codes: XW0439A
A hospitalized oncology patient develops severe neutropenic sepsis requiring broad-spectrum intravenous anti-infective therapy that cannot be reliably delivered peripherally. A percutaneous central venous catheter is used to introduce a newer anti-infective agent into the central vein for continuous infusion and rapid systemic delivery while inpatient care and monitoring continue. The procedure specifically documents percutaneous introduction into a central vein. Typical codes: XW0434A, XW04396
A patient previously treated with CAR T-cell therapy is admitted for administration of an autologous engineered chimeric antigen receptor T-cell product requiring central venous infusion under close inpatient observation. The cell therapy is infused via a percutaneously placed central venous access to ensure secure delivery of the immune effector cell therapy and to allow management of potential acute infusion reactions. Documentation indicates introduction of the cell therapy into a central vein via percutaneous approach. Typical codes: XW043C7, XW043FA

Related Codes

XW00-SKIN-INTRODUCTION

ICD-10-PCS Code For Skin: Procedure Code Group Overview

XW01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

XW02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

XW03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

XW05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

XW06-CEREBRAL-VENTRICLE-INTRODUCTION

ICD-10-PCS Code For Cerebral Ventricle: Procedure Code Group Overview

XW0D-MOUTH-AND-PHARYNX-INTRODUCTION

ICD-10-PCS Code For Mouth And Pharynx: Procedure Code Group Overview

XW0E-EAR-INTRODUCTION-EAR-S-INTRODUCTION

ICD-10-PCS Code For Ear(s): Procedure Code Group Overview

XW0G-UPPER-GI-INTRODUCTION

ICD-10-PCS Code For Upper Gi: Procedure Code Group Overview

XW0H-LOWER-GI-INTRODUCTION

ICD-10-PCS Code For Lower GI: Procedure Code Group Overview

Showing 1–10 of 17

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

When to Use

ICD-10-PCS Codes

55 rows

ICD-10-PCS Code	Description
XW04308	Introduction of Spesolimab Monoclonal Antibody into Central Vein, Percutaneous Approach, New Technology Group 8
XW0430B	Introduction of Alpha1-proteinase Inhibitor into Central Vein, Percutaneous Approach, New Technology Group 11
XW0431B	Introduction of Anitocabtagene Autoleucel Immunotherapy into Central Vein, Percutaneous Approach, New Technology Group 11
XW0433A	Introduction of Bentracimab, Ticagrelor Reversal Agent into Central Vein, Percutaneous Approach, New Technology Group 10
XW0434A	Introduction of Cefepime-taniborbactam Anti-infective into Central Vein, Percutaneous Approach, New Technology Group 10
XW04357	Introduction of Narsoplimab Monoclonal Antibody into Central Vein, Percutaneous Approach, New Technology Group 7
XW04358	Introduction of Mosunetuzumab Antineoplastic into Central Vein, Percutaneous Approach, New Technology Group 8
XW0435A	Introduction of Ceftobiprole Medocaril Anti-infective into Central Vein, Percutaneous Approach, New Technology Group 10
XW04367	Introduction of Terlipressin into Central Vein, Percutaneous Approach, New Technology Group 7
XW04368	Introduction of Afamitresgene Autoleucel Immunotherapy into Central Vein, Percutaneous Approach, New Technology Group 8

Showing 1–10 of 55

DRG Codes

1 rows

DRG Code	Description
018	Chimeric Antigen Receptor (CAR) T-Cell and Other Immunotherapies

Typical Clinical Scenarios

An adult patient with relapsed refractory diffuse large B-cell lymphoma is admitted for inpatient administration of a novel bispecific antineoplastic infusion requiring central venous access for delivery because peripheral access is inadequate and the agent is vesicant/potent. The patient receives a percutaneous central line placement and the targeted antineoplastic agent is introduced into the central vein during the admission to ensure controlled dosing and monitoring for cytokine release. The procedure documents introduction into a central venous location. Typical codes: XW0439A
A hospitalized oncology patient develops severe neutropenic sepsis requiring broad-spectrum intravenous anti-infective therapy that cannot be reliably delivered peripherally. A percutaneous central venous catheter is used to introduce a newer anti-infective agent into the central vein for continuous infusion and rapid systemic delivery while inpatient care and monitoring continue. The procedure specifically documents percutaneous introduction into a central vein. Typical codes: XW0434A, XW04396
A patient previously treated with CAR T-cell therapy is admitted for administration of an autologous engineered chimeric antigen receptor T-cell product requiring central venous infusion under close inpatient observation. The cell therapy is infused via a percutaneously placed central venous access to ensure secure delivery of the immune effector cell therapy and to allow management of potential acute infusion reactions. Documentation indicates introduction of the cell therapy into a central vein via percutaneous approach. Typical codes: XW043C7, XW043FA

Related Codes

XW00-SKIN-INTRODUCTION

ICD-10-PCS Code For Skin: Procedure Code Group Overview

XW01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

XW02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

XW03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

XW05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

XW06-CEREBRAL-VENTRICLE-INTRODUCTION

ICD-10-PCS Code For Cerebral Ventricle: Procedure Code Group Overview

XW0D-MOUTH-AND-PHARYNX-INTRODUCTION

ICD-10-PCS Code For Mouth And Pharynx: Procedure Code Group Overview

XW0E-EAR-INTRODUCTION-EAR-S-INTRODUCTION

ICD-10-PCS Code For Ear(s): Procedure Code Group Overview

XW0G-UPPER-GI-INTRODUCTION

ICD-10-PCS Code For Upper Gi: Procedure Code Group Overview

XW0H-LOWER-GI-INTRODUCTION

ICD-10-PCS Code For Lower GI: Procedure Code Group Overview

Showing 1–10 of 17

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Central Vein: Procedure Code Group Overview policy alerts

Central Vein Introduction Procedure Overview

Code Attributes

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Central Vein: Procedure Code Group Overview policy alerts

Central Vein Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-PCS section and operation apply to central vein introduction procedures?

When should XW04 codes be used for inpatient documentation?

How are individual codes in the XW04 group formatted and identified?

What is the significance of New Technology Group values in these codes?

Which DRG is related to the XW04 central vein introduction procedure group?

References

When to Use

ICD-10-PCS Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-PCS section and operation apply to central vein introduction procedures?

When should XW04 codes be used for inpatient documentation?

How are individual codes in the XW04 group formatted and identified?

What is the significance of New Technology Group values in these codes?

Which DRG is related to the XW04 central vein introduction procedure group?

References