ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group XW01 includes procedures performed to introduce substances into the subcutaneous tissue in Anatomical Regions. These ICD-10-PCS codes are used for inpatient documentation when a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance (excluding blood or blood products) is placed into the subcutaneous tissue. Accurate coding within the ICD-10-PCS XW01 group is essential for proper inpatient reimbursement, as it captures the procedure performed and supports clinical documentation accuracy.

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Subcutaneous Tissue Introduction Procedure Overview

This procedure group includes introduction procedures targeting the subcutaneous tissue within the Anatomical Regions body system and classified in the New Technology section. These procedures involve placing therapeutic, diagnostic, nutritional, physiological, or prophylactic substances into the subcutaneous tissue. Accurate ICD-10-PCS coding ensures inpatient documentation reflects the specific introduction performed and supports correct inpatient reimbursement.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
X	Section	New Technology
W	Body System	Anatomical Regions
0	Operation	Introduction
1	Body Part	Subcutaneous Tissue

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Subcutaneous Tissue Introduction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
X	Section	New Technology
W	Body System	Anatomical Regions
0	Operation	Introduction
1	Body Part	Subcutaneous Tissue

When to Use

Use a code from this group when a substance is deliberately introduced into the subcutaneous tissue for therapeutic, diagnostic, nutritional, physiological, or prophylactic purposes. Do not use these codes for blood or blood product administration or for introductions into deeper tissue layers or other body systems.

ICD-10-PCS Codes

19 rows

ICD-10-PCS Code	Description
XW01318	Introduction of Daratumumab and Hyaluronidase-fihj into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 8
XW01329	Introduction of Talquetamab Antineoplastic into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 9
XW01348	Introduction of Teclistamab Antineoplastic into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 8
XW0136A	Introduction of Dasiglucagon into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 10
XW01397	Introduction of Satralizumab-mwge into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 7
XW013F5	Introduction of Other New Technology Therapeutic Substance into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 5
XW013G6	Introduction of REGN-COV2 Monoclonal Antibody into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 6
XW013H6	Introduction of Other New Technology Monoclonal Antibody into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 6
XW013K6	Introduction of Leronlimab Monoclonal Antibody into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 6
XW013L9	Introduction of Elranatamab Antineoplastic into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 9

Showing 1–10 of 19

Typical Clinical Scenarios

An elderly patient with advanced multiple myeloma admitted for management of progressive disease and difficulty with intravenous access requires administration of a monoclonal antibody therapy that is formulated for subcutaneous delivery; inpatient care is needed for monitoring post-dose infusion-related reactions and coordination of oncology services. A percutaneous subcutaneous injection of the specified therapeutic is performed to deliver the medication. Typical codes: XW01318, XW01348
A hospitalized adult with severe hypoglycemia unresponsive to oral glucose receives an emergency subcutaneous injection of a rapid-acting glucagon analog to restore blood glucose while inpatient monitoring and endocrine consultation are provided; the subcutaneous route is chosen for rapid absorption when IV access is delayed. The procedure documents introduction of a rescue therapeutic into the subcutaneous tissue to correct the metabolic emergency. Typical codes: XW0136A
An inpatient receiving post-exposure prophylaxis or immunization as part of inpatient public health management receives a scheduled subcutaneous vaccine dose while hospitalized for another primary condition; the vaccine is given per protocol and the patient is observed for adverse reaction before discharge. The procedure records the percutaneous subcutaneous administration of the vaccine dose. Typical codes: XW013S6, XW013T6

Related Codes

XW00-SKIN-INTRODUCTION

ICD-10-PCS Code For Skin: Procedure Code Group Overview

XW02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

XW03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

XW04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

XW05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

XW06-CEREBRAL-VENTRICLE-INTRODUCTION

ICD-10-PCS Code For Cerebral Ventricle: Procedure Code Group Overview

XW0D-MOUTH-AND-PHARYNX-INTRODUCTION

ICD-10-PCS Code For Mouth And Pharynx: Procedure Code Group Overview

XW0E-EAR-INTRODUCTION-EAR-S-INTRODUCTION

ICD-10-PCS Code For Ear(s): Procedure Code Group Overview

XW0G-UPPER-GI-INTRODUCTION

ICD-10-PCS Code For Upper Gi: Procedure Code Group Overview

XW0H-LOWER-GI-INTRODUCTION

ICD-10-PCS Code For Lower GI: Procedure Code Group Overview

Showing 1–10 of 17

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

19 rows

ICD-10-PCS Code	Description
XW01318	Introduction of Daratumumab and Hyaluronidase-fihj into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 8
XW01329	Introduction of Talquetamab Antineoplastic into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 9
XW01348	Introduction of Teclistamab Antineoplastic into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 8
XW0136A	Introduction of Dasiglucagon into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 10
XW01397	Introduction of Satralizumab-mwge into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 7
XW013F5	Introduction of Other New Technology Therapeutic Substance into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 5
XW013G6	Introduction of REGN-COV2 Monoclonal Antibody into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 6
XW013H6	Introduction of Other New Technology Monoclonal Antibody into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 6
XW013K6	Introduction of Leronlimab Monoclonal Antibody into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 6
XW013L9	Introduction of Elranatamab Antineoplastic into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 9

Showing 1–10 of 19

Typical Clinical Scenarios

An elderly patient with advanced multiple myeloma admitted for management of progressive disease and difficulty with intravenous access requires administration of a monoclonal antibody therapy that is formulated for subcutaneous delivery; inpatient care is needed for monitoring post-dose infusion-related reactions and coordination of oncology services. A percutaneous subcutaneous injection of the specified therapeutic is performed to deliver the medication. Typical codes: XW01318, XW01348
A hospitalized adult with severe hypoglycemia unresponsive to oral glucose receives an emergency subcutaneous injection of a rapid-acting glucagon analog to restore blood glucose while inpatient monitoring and endocrine consultation are provided; the subcutaneous route is chosen for rapid absorption when IV access is delayed. The procedure documents introduction of a rescue therapeutic into the subcutaneous tissue to correct the metabolic emergency. Typical codes: XW0136A
An inpatient receiving post-exposure prophylaxis or immunization as part of inpatient public health management receives a scheduled subcutaneous vaccine dose while hospitalized for another primary condition; the vaccine is given per protocol and the patient is observed for adverse reaction before discharge. The procedure records the percutaneous subcutaneous administration of the vaccine dose. Typical codes: XW013S6, XW013T6

Related Codes

XW00-SKIN-INTRODUCTION

ICD-10-PCS Code For Skin: Procedure Code Group Overview

XW02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

XW03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

XW04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

XW05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

XW06-CEREBRAL-VENTRICLE-INTRODUCTION

ICD-10-PCS Code For Cerebral Ventricle: Procedure Code Group Overview

XW0D-MOUTH-AND-PHARYNX-INTRODUCTION

ICD-10-PCS Code For Mouth And Pharynx: Procedure Code Group Overview

XW0E-EAR-INTRODUCTION-EAR-S-INTRODUCTION

ICD-10-PCS Code For Ear(s): Procedure Code Group Overview

XW0G-UPPER-GI-INTRODUCTION

ICD-10-PCS Code For Upper Gi: Procedure Code Group Overview

XW0H-LOWER-GI-INTRODUCTION

ICD-10-PCS Code For Lower GI: Procedure Code Group Overview

Showing 1–10 of 17

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview policy alerts

Subcutaneous Tissue Introduction Procedure Overview

Code Attributes

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview policy alerts

Subcutaneous Tissue Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-PCS code group covers introduction into subcutaneous tissue?

What are the key attributes of the XW01 code group?

Which substances are represented among codes in the XW01 group?

How are approaches and technology groups indicated for codes in XW01?

Why is accurate coding within the XW01 group important?

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-PCS code group covers introduction into subcutaneous tissue?

What are the key attributes of the XW01 code group?

Which substances are represented among codes in the XW01 group?

How are approaches and technology groups indicated for codes in XW01?

Why is accurate coding within the XW01 group important?

References