ICD-10-PCS Code For Skin: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group XW00 includes procedures performed to introduce therapeutic substances in the skin. These ICD-10-PCS codes are used for inpatient documentation when a new technology product is placed into or onto the skin by an external approach. Accurate coding within the ICD-10-PCS XW00 group is essential for proper inpatient reimbursement, as it captures the procedure performed and supports clinical documentation accuracy.

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Skin Introduction Procedure Overview

The procedures in ICD-10 PCS XW00 involve introduction of therapeutic substances into the skin and target the skin anatomical region. These New Technology section procedures place a substance into or onto the skin by external approach and are used when a novel or recently approved product is administered. Accurate coding is important for inpatient reimbursement because it documents the specific operation, substance, and body part treated, which affects case mix and payment.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
X	Section	New Technology
W	Body System	Anatomical Regions
0	Operation	Introduction
0	Body Part	Skin

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ICD-10-PCS Code For Skin: Procedure Code Group Overview

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Skin Introduction Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
X	Section	New Technology
W	Body System	Anatomical Regions
0	Operation	Introduction
0	Body Part	Skin

When to Use

Select a code from this group when a novel or newly approved therapeutic substance is applied to or introduced into the skin during an inpatient encounter. Use these codes to document the introduction operation, the external approach, and the skin as the treated body part for accurate inpatient procedure reporting.

ICD-10-PCS Codes

1 rows

ICD-10-PCS Code	Description
XW00X27	Introduction of Anacaulase-bcdb into Skin, External Approach, New Technology Group 7

Typical Clinical Scenarios

An elderly patient with a chronic, non-healing venous stasis ulcer of the lower leg is admitted for inpatient wound management after outpatient measures failed. The care team applies a newly approved topical biologic, Anacaulase-bcdb, directly to the affected skin surface under controlled inpatient settings to promote debridement and healing. The procedure documents introduction of the therapeutic agent onto the skin by external approach to support advanced wound care. Typical codes: XW00X27
A middle-aged patient presents to the emergency department with a traumatic partial-thickness burn to the forearm requiring inpatient observation for infection risk and pain control. As part of acute management, clinicians apply the novel topical agent Anacaulase-bcdb to the burned skin to assist in enzymatic debridement and reduce necrotic tissue burden. The intervention is coded as introduction of the therapeutic substance onto the skin by external approach during the inpatient encounter. Typical codes: XW00X27
A patient previously treated with a standard topical regimen for a refractory dermatologic lesion is readmitted for escalating local inflammation and poor response to therapy. The care team discontinues prior treatments and applies Anacaulase-bcdb to the lesion on the skin in an inpatient setting to attempt a different mechanism of action; this is documented as introduction of the new therapeutic agent onto the skin by external approach. The procedure represents use of a newly available technology after prior therapies failed. Typical codes: XW00X27

Related Codes

XW01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

XW02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

XW03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

XW04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

XW05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

XW06-CEREBRAL-VENTRICLE-INTRODUCTION

ICD-10-PCS Code For Cerebral Ventricle: Procedure Code Group Overview

XW0D-MOUTH-AND-PHARYNX-INTRODUCTION

ICD-10-PCS Code For Mouth And Pharynx: Procedure Code Group Overview

XW0E-EAR-INTRODUCTION-EAR-S-INTRODUCTION

ICD-10-PCS Code For Ear(s): Procedure Code Group Overview

XW0G-UPPER-GI-INTRODUCTION

ICD-10-PCS Code For Upper Gi: Procedure Code Group Overview

XW0H-LOWER-GI-INTRODUCTION

ICD-10-PCS Code For Lower GI: Procedure Code Group Overview

Showing 1–10 of 17

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

1 rows

ICD-10-PCS Code	Description
XW00X27	Introduction of Anacaulase-bcdb into Skin, External Approach, New Technology Group 7

Typical Clinical Scenarios

An elderly patient with a chronic, non-healing venous stasis ulcer of the lower leg is admitted for inpatient wound management after outpatient measures failed. The care team applies a newly approved topical biologic, Anacaulase-bcdb, directly to the affected skin surface under controlled inpatient settings to promote debridement and healing. The procedure documents introduction of the therapeutic agent onto the skin by external approach to support advanced wound care. Typical codes: XW00X27
A middle-aged patient presents to the emergency department with a traumatic partial-thickness burn to the forearm requiring inpatient observation for infection risk and pain control. As part of acute management, clinicians apply the novel topical agent Anacaulase-bcdb to the burned skin to assist in enzymatic debridement and reduce necrotic tissue burden. The intervention is coded as introduction of the therapeutic substance onto the skin by external approach during the inpatient encounter. Typical codes: XW00X27
A patient previously treated with a standard topical regimen for a refractory dermatologic lesion is readmitted for escalating local inflammation and poor response to therapy. The care team discontinues prior treatments and applies Anacaulase-bcdb to the lesion on the skin in an inpatient setting to attempt a different mechanism of action; this is documented as introduction of the new therapeutic agent onto the skin by external approach. The procedure represents use of a newly available technology after prior therapies failed. Typical codes: XW00X27

Related Codes

XW01-SUBCUTANEOUS-TISSUE-INTRODUCTION

ICD-10-PCS Code For Subcutaneous Tissue: Procedure Code Group Overview

XW02-MUSCLE-INTRODUCTION

ICD-10-PCS Code For Muscle: Procedure Code Group Overview

XW03-PERIPHERAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Peripheral Vein: Procedure Code Group Overview

XW04-CENTRAL-VEIN-INTRODUCTION

ICD-10-PCS Code For Central Vein: Procedure Code Group Overview

XW05-PERIPHERAL-ARTERY-INTRODUCTION

ICD-10-PCS Code For Peripheral Artery: Procedure Code Group Overview

XW06-CEREBRAL-VENTRICLE-INTRODUCTION

ICD-10-PCS Code For Cerebral Ventricle: Procedure Code Group Overview

XW0D-MOUTH-AND-PHARYNX-INTRODUCTION

ICD-10-PCS Code For Mouth And Pharynx: Procedure Code Group Overview

XW0E-EAR-INTRODUCTION-EAR-S-INTRODUCTION

ICD-10-PCS Code For Ear(s): Procedure Code Group Overview

XW0G-UPPER-GI-INTRODUCTION

ICD-10-PCS Code For Upper Gi: Procedure Code Group Overview

XW0H-LOWER-GI-INTRODUCTION

ICD-10-PCS Code For Lower GI: Procedure Code Group Overview

Showing 1–10 of 17

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-PCS Code For Skin: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Skin: Procedure Code Group Overview policy alerts

Skin Introduction Procedure Overview

Code Attributes

ICD-10-PCS Code For Skin: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Skin: Procedure Code Group Overview policy alerts

Skin Introduction Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

What procedures are included in ICD-10-PCS code group XW00?

What is the operation and body part specified for XW00 codes?

Which specific ICD-10-PCS code is listed in this group?

How does accurate coding in XW00 affect inpatient documentation and reimbursement?

Are there related DRGs listed for the XW00 group?

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

What procedures are included in ICD-10-PCS code group XW00?

What is the operation and body part specified for XW00 codes?

Which specific ICD-10-PCS code is listed in this group?

How does accurate coding in XW00 affect inpatient documentation and reimbursement?

Are there related DRGs listed for the XW00 group?

References