ICD-10-PCS Code For Other Replacement Medication: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group HZ99 includes procedures performed to administer pharmacotherapy using replacement medications for substance abuse treatment. These ICD-10-PCS codes are used for inpatient documentation when replacement medication pharmacotherapy is provided as part of addiction treatment during a hospital stay. Accurate coding within the ICD-10-PCS HZ99 group is essential for proper inpatient reimbursement, as it captures the procedure performed and supports clinical documentation accuracy.

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Other Replacement Medication Pharmacotherapy Procedure Overview

This group includes pharmacotherapy procedures involving the administration of replacement medications for the treatment of substance use disorders. These procedures do not target an anatomical body system but involve the use of specific replacement medications as part of addiction treatment. Accurate coding ensures inpatient records reflect the pharmacologic intervention provided and supports appropriate inpatient reimbursement and case mix assignment.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
H	Section	Substance Abuse Treatment
Z	Body System	None
9	Operation	Pharmacotherapy
9	Body Part	Other Replacement Medication

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ICD-10-PCS Code For Other Replacement Medication: Procedure Code Group Overview

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Other Replacement Medication Pharmacotherapy Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
H	Section	Substance Abuse Treatment
Z	Body System	None
9	Operation	Pharmacotherapy
9	Body Part	Other Replacement Medication

When to Use

Use a code from this group when replacement medication pharmacotherapy is provided to treat substance use disorders during an inpatient admission. Assign these codes when the primary procedure performed is the pharmacotherapeutic administration of a replacement medication for addiction treatment.

ICD-10-PCS Codes

1 rows

ICD-10-PCS Code	Description
HZ99ZZZ	Pharmacotherapy for Substance Abuse Treatment, Other Replacement Medication

Typical Clinical Scenarios

A middle-aged patient is admitted from the emergency department after presenting with severe opioid withdrawal symptoms following abrupt cessation of heroin use. During the inpatient stay the medical team initiates a replacement medication regimen to stabilize withdrawal and begin addiction treatment, documenting the pharmacotherapy administration as the primary procedure. A code from the group is assigned to reflect inpatient delivery of replacement medication pharmacotherapy for substance abuse management. Typical codes: HZ99ZZZ
A patient with a long-standing opioid use disorder is admitted electively for optimization of their addiction treatment plan and transition from outpatient agents to an inpatient-monitored replacement medication to ensure dosing accuracy and safety. The planned inpatient pharmacotherapy administration facilitates stabilization and coordination with outpatient follow-up prior to discharge. The procedure is coded to capture the inpatient replacement medication pharmacotherapy delivered as part of the treatment plan. Typical codes: HZ99ZZZ
A patient hospitalized for a medical complication unrelated to addiction has poorly controlled withdrawal symptoms while inpatient, interfering with medical care; the team initiates replacement medication pharmacotherapy to control withdrawal and allow treatment of the primary condition. The inpatient administration of the replacement medication is documented as the procedure to address the complication of unmanaged substance withdrawal during the admission. Typical codes: HZ99ZZZ

ICD-10-PCS Code For Nicotine Replacement: Procedure Code Group Overview

HZ91-METHADONE-MAINTENANCE-PHARMACOTHERAPY

ICD-10-PCS Code for Methadone Maintenance: Procedure Code Group Overview

HZ92-LEVO-ALPHA-ACETYL-METHADOL-PHARMACOTHERAPY

ICD-10-PCS Code For Levo Alpha Acetyl Methadol: Procedure Code Group Overview

HZ93-ANTABUSE-PHARMACOTHERAPY

ICD-10-PCS Code For Antabuse: Procedure Code Group Overview

HZ94-NALTREXONE-PHARMACOTHERAPY

ICD-10-PCS Code For Naltrexone: Procedure Code Group Overview

HZ95-NALOXONE-ALTERATION

ICD-10-PCS Code For Naloxone: Procedure Code Group Overview

HZ96-CLONIDINE-PHARMACOTHERAPY

ICD-10-PCS Code For Clonidine: Procedure Code Group Overview

HZ97-BUPROPION-PHARMACOTHERAPY

ICD-10-PCS Code For Bupropion: Procedure Code Group Overview

HZ98-PSYCHIATRIC-MEDICATION-PHARMACOTHERAPY

ICD-10-PCS Code For Psychiatric Medication: Procedure Code Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

1 rows

ICD-10-PCS Code	Description
HZ99ZZZ	Pharmacotherapy for Substance Abuse Treatment, Other Replacement Medication

Typical Clinical Scenarios

A middle-aged patient is admitted from the emergency department after presenting with severe opioid withdrawal symptoms following abrupt cessation of heroin use. During the inpatient stay the medical team initiates a replacement medication regimen to stabilize withdrawal and begin addiction treatment, documenting the pharmacotherapy administration as the primary procedure. A code from the group is assigned to reflect inpatient delivery of replacement medication pharmacotherapy for substance abuse management. Typical codes: HZ99ZZZ
A patient with a long-standing opioid use disorder is admitted electively for optimization of their addiction treatment plan and transition from outpatient agents to an inpatient-monitored replacement medication to ensure dosing accuracy and safety. The planned inpatient pharmacotherapy administration facilitates stabilization and coordination with outpatient follow-up prior to discharge. The procedure is coded to capture the inpatient replacement medication pharmacotherapy delivered as part of the treatment plan. Typical codes: HZ99ZZZ
A patient hospitalized for a medical complication unrelated to addiction has poorly controlled withdrawal symptoms while inpatient, interfering with medical care; the team initiates replacement medication pharmacotherapy to control withdrawal and allow treatment of the primary condition. The inpatient administration of the replacement medication is documented as the procedure to address the complication of unmanaged substance withdrawal during the admission. Typical codes: HZ99ZZZ

ICD-10-PCS Code For Nicotine Replacement: Procedure Code Group Overview

HZ91-METHADONE-MAINTENANCE-PHARMACOTHERAPY

ICD-10-PCS Code for Methadone Maintenance: Procedure Code Group Overview

HZ92-LEVO-ALPHA-ACETYL-METHADOL-PHARMACOTHERAPY

ICD-10-PCS Code For Levo Alpha Acetyl Methadol: Procedure Code Group Overview

HZ93-ANTABUSE-PHARMACOTHERAPY

ICD-10-PCS Code For Antabuse: Procedure Code Group Overview

HZ94-NALTREXONE-PHARMACOTHERAPY

ICD-10-PCS Code For Naltrexone: Procedure Code Group Overview

HZ95-NALOXONE-ALTERATION

ICD-10-PCS Code For Naloxone: Procedure Code Group Overview

HZ96-CLONIDINE-PHARMACOTHERAPY

ICD-10-PCS Code For Clonidine: Procedure Code Group Overview

HZ97-BUPROPION-PHARMACOTHERAPY

ICD-10-PCS Code For Bupropion: Procedure Code Group Overview

HZ98-PSYCHIATRIC-MEDICATION-PHARMACOTHERAPY

ICD-10-PCS Code For Psychiatric Medication: Procedure Code Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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ICD-10-PCS Code For Other Replacement Medication: Procedure Code Group Overview

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Other Replacement Medication Pharmacotherapy Procedure Overview

Code Attributes

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Other Replacement Medication Pharmacotherapy Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-PCS Code For Other Replacement Medication: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Other Replacement Medication: Procedure Code Group Overview policy alerts

Other Replacement Medication Pharmacotherapy Procedure Overview

Code Attributes

ICD-10-PCS Code For Other Replacement Medication: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Other Replacement Medication: Procedure Code Group Overview policy alerts

Other Replacement Medication Pharmacotherapy Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

What procedures are included in the HZ99 ICD-10-PCS code group?

Which specific ICD-10-PCS code represents Other Replacement Medication pharmacotherapy?

How is accurate coding within the HZ99 group important for inpatient care?

What are the code attributes for the HZ99 procedure group?

Are there related DRGs listed for the HZ99 code group?

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

What procedures are included in the HZ99 ICD-10-PCS code group?

Which specific ICD-10-PCS code represents Other Replacement Medication pharmacotherapy?

How is accurate coding within the HZ99 group important for inpatient care?

What are the code attributes for the HZ99 procedure group?

Are there related DRGs listed for the HZ99 code group?

References