Naltrexone ICD-10-PCS Coding & Reimbursement (HZ94)

ICD-10-PCS Code For Naltrexone: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group HZ94 includes procedures performed to provide pharmacotherapy with naltrexone for substance abuse treatment. These ICD-10-PCS codes are used for inpatient documentation when medication-based therapy with naltrexone is administered as part of addiction treatment. Accurate coding within the ICD-10-PCS HZ94 group is essential for proper inpatient reimbursement, as it captures the pharmacologic treatment provided and supports clinical documentation accuracy.

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Naltrexone Pharmacotherapy Procedure Overview

Procedures in this group involve the administration of naltrexone as pharmacotherapy for substance use disorder treatment. These interventions do not target an anatomical body system but instead represent medication-based therapy to reduce opioid or alcohol relapse. Accurate coding of these pharmacotherapy procedures ensures inpatient records reflect the treatment provided and supports appropriate case mix and payment.

Character	ICD-10-PCS Category	Code Group Details
H	Section	Substance Abuse Treatment
Z	Body System	None
9	Operation	Pharmacotherapy
4	Body Part	Naltrexone

Character

ICD-10-PCS Category

Code Group Details

Section

Substance Abuse Treatment

Body System

None

Operation

Pharmacotherapy

Body Part

Naltrexone

ICD-10-PCS Code For Naltrexone: Procedure Code Group Overview

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Naltrexone Pharmacotherapy Procedure Overview

Character	ICD-10-PCS Category	Code Group Details
H	Section	Substance Abuse Treatment
Z	Body System	None
9	Operation	Pharmacotherapy
4	Body Part	Naltrexone

Character

ICD-10-PCS Category

Code Group Details

Section

Substance Abuse Treatment

Body System

None

Operation

Pharmacotherapy

Body Part

Naltrexone

ICD-10-PCS Code	Description
HZ94ZZZ	Pharmacotherapy for Substance Abuse Treatment, Naltrexone

ICD-10-PCS Code

Description

HZ94ZZZ

Pharmacotherapy for Substance Abuse Treatment, Naltrexone

Typical Clinical Scenarios

An adult admitted from the emergency department following acute opioid overdose who is medically stabilized but requires initiation of pharmacologic addiction treatment during the inpatient stay to prevent relapse; inpatient teams administer naltrexone as part of medication-assisted therapy once opioid abstinence is confirmed and the patient is monitored for withdrawal and response. Typical codes: HZ94ZZZ
A patient with severe alcohol use disorder elects for a planned inpatient detoxification and rehabilitation admission where naltrexone is started under controlled monitoring to reduce craving and support early recovery; naltrexone administration is provided during the scheduled inpatient treatment episode as part of the pharmacotherapy plan. Typical codes: HZ94ZZZ
A hospitalized patient with a history of opioid dependence who previously received naltrexone but has experienced relapse and is readmitted for supervised reinitiation of naltrexone therapy after stabilization of acute medical issues; the inpatient team documents and administers naltrexone to reestablish maintenance pharmacotherapy. Typical codes: HZ94ZZZ

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

ICD-10-PCS Code	Description
HZ94ZZZ	Pharmacotherapy for Substance Abuse Treatment, Naltrexone

An adult admitted from the emergency department following acute opioid overdose who is medically stabilized but requires initiation of pharmacologic addiction treatment during the inpatient stay to prevent relapse; inpatient teams administer naltrexone as part of medication-assisted therapy once opioid abstinence is confirmed and the patient is monitored for withdrawal and response. Typical codes: HZ94ZZZ
A patient with severe alcohol use disorder elects for a planned inpatient detoxification and rehabilitation admission where naltrexone is started under controlled monitoring to reduce craving and support early recovery; naltrexone administration is provided during the scheduled inpatient treatment episode as part of the pharmacotherapy plan. Typical codes: HZ94ZZZ
A hospitalized patient with a history of opioid dependence who previously received naltrexone but has experienced relapse and is readmitted for supervised reinitiation of naltrexone therapy after stabilization of acute medical issues; the inpatient team documents and administers naltrexone to reestablish maintenance pharmacotherapy. Typical codes: HZ94ZZZ

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ICD-10-PCS Code For Naltrexone: Procedure Code Group Overview

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Naltrexone Pharmacotherapy Procedure Overview

Code Attributes

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ICD-10-PCS Code For Naltrexone: Procedure Code Group Overview

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Naltrexone Pharmacotherapy Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-PCS Code For Naltrexone: Procedure Code Group Overview

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Naltrexone Pharmacotherapy Procedure Overview

Code Attributes

ICD-10-PCS Code For Naltrexone: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Naltrexone: Procedure Code Group Overview policy alerts

Naltrexone Pharmacotherapy Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

What does the ICD-10-PCS code group HZ94 represent?

Which specific ICD-10-PCS code in this group identifies naltrexone pharmacotherapy?

What section and operation attributes are assigned to HZ94 codes?

How is accurate coding within the HZ94 group important for inpatient care documentation?

Are there treatment recommendations provided for use of naltrexone in this content?

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

What does the ICD-10-PCS code group HZ94 represent?

Which specific ICD-10-PCS code in this group identifies naltrexone pharmacotherapy?

What section and operation attributes are assigned to HZ94 codes?

How is accurate coding within the HZ94 group important for inpatient care documentation?

Are there treatment recommendations provided for use of naltrexone in this content?

References