ICD-10-PCS Code For Bupropion: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group HZ97 includes procedures performed to administer pharmacotherapy using bupropion for treatment of substance use disorders. These ICD-10-PCS codes are used for inpatient documentation when a patient receives bupropion as part of a substance abuse treatment regimen during a hospitalization. Accurate coding within the ICD-10-PCS HZ97 group is essential for proper inpatient reimbursement, as it captures the pharmacotherapy provided and supports clinical documentation accuracy.

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Bupropion Pharmacotherapy Procedure Overview

Procedures in this group involve administration of bupropion as pharmacotherapy for substance abuse treatment, focusing on medication management rather than an anatomical body system. These procedures document initiation, adjustment, or continuation of bupropion therapy during an inpatient stay. Accurate coding ensures the clinical action of pharmacotherapy is captured for inpatient records and reimbursement.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
H	Section	Substance Abuse Treatment
Z	Body System	None
9	Operation	Pharmacotherapy
7	Body Part	Bupropion

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ICD-10-PCS Code For Bupropion: Procedure Code Group Overview

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Bupropion Pharmacotherapy Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
H	Section	Substance Abuse Treatment
Z	Body System	None
9	Operation	Pharmacotherapy
7	Body Part	Bupropion

When to Use

Use a code from this group when bupropion is administered as part of an inpatient substance abuse treatment plan. Assign the code to reflect the pharmacotherapy action performed during the admission, such as starting or modifying bupropion therapy.

ICD-10-PCS Codes

1 rows

ICD-10-PCS Code	Description
HZ97ZZZ	Pharmacotherapy for Substance Abuse Treatment, Bupropion

Typical Clinical Scenarios

A middle-aged patient with severe major depressive disorder and long-standing tobacco dependence is admitted for exacerbation of depressive symptoms with suicidal ideation and nicotine withdrawal during hospital stay. The inpatient team initiates bupropion as part of an integrated pharmacologic plan to address both mood symptoms and to support smoking cessation while closely monitoring for side effects in the acute psychiatric setting. Typical codes: HZ97ZZZ
A young adult admitted to a medical ward after an overdose related to stimulant use disorder stabilizes medically but requires inpatient initiation of substance abuse treatment; the addiction psychiatry consult recommends starting bupropion to reduce cravings and aid relapse prevention during the hospitalization. The code documents the initiation of bupropion pharmacotherapy as part of the inpatient substance use treatment plan prior to discharge with outpatient follow-up. Typical codes: HZ97ZZZ
An older patient with chronic obstructive pulmonary disease (COPD) and prior failed nicotine cessation attempts is hospitalized for COPD exacerbation; during the admission the multidisciplinary team adjusts the patient’s outpatient medications and restarts bupropion to manage tobacco dependence and reduce readmission risk from continued smoking. The procedure code captures the inpatient administration or modification of bupropion therapy during this elective medical admission. Typical codes: HZ97ZZZ

ICD-10-PCS Code For Nicotine Replacement: Procedure Code Group Overview

HZ91-METHADONE-MAINTENANCE-PHARMACOTHERAPY

ICD-10-PCS Code for Methadone Maintenance: Procedure Code Group Overview

HZ92-LEVO-ALPHA-ACETYL-METHADOL-PHARMACOTHERAPY

ICD-10-PCS Code For Levo Alpha Acetyl Methadol: Procedure Code Group Overview

HZ93-ANTABUSE-PHARMACOTHERAPY

ICD-10-PCS Code For Antabuse: Procedure Code Group Overview

HZ94-NALTREXONE-PHARMACOTHERAPY

ICD-10-PCS Code For Naltrexone: Procedure Code Group Overview

HZ95-NALOXONE-ALTERATION

ICD-10-PCS Code For Naloxone: Procedure Code Group Overview

HZ96-CLONIDINE-PHARMACOTHERAPY

ICD-10-PCS Code For Clonidine: Procedure Code Group Overview

HZ98-PSYCHIATRIC-MEDICATION-PHARMACOTHERAPY

ICD-10-PCS Code For Psychiatric Medication: Procedure Code Group Overview

HZ99-OTHER-REPLACEMENT-MEDICATION-PHARMACOTHERAPY

ICD-10-PCS Code For Other Replacement Medication: Procedure Code Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

1 rows

ICD-10-PCS Code	Description
HZ97ZZZ	Pharmacotherapy for Substance Abuse Treatment, Bupropion

Typical Clinical Scenarios

A middle-aged patient with severe major depressive disorder and long-standing tobacco dependence is admitted for exacerbation of depressive symptoms with suicidal ideation and nicotine withdrawal during hospital stay. The inpatient team initiates bupropion as part of an integrated pharmacologic plan to address both mood symptoms and to support smoking cessation while closely monitoring for side effects in the acute psychiatric setting. Typical codes: HZ97ZZZ
A young adult admitted to a medical ward after an overdose related to stimulant use disorder stabilizes medically but requires inpatient initiation of substance abuse treatment; the addiction psychiatry consult recommends starting bupropion to reduce cravings and aid relapse prevention during the hospitalization. The code documents the initiation of bupropion pharmacotherapy as part of the inpatient substance use treatment plan prior to discharge with outpatient follow-up. Typical codes: HZ97ZZZ
An older patient with chronic obstructive pulmonary disease (COPD) and prior failed nicotine cessation attempts is hospitalized for COPD exacerbation; during the admission the multidisciplinary team adjusts the patient’s outpatient medications and restarts bupropion to manage tobacco dependence and reduce readmission risk from continued smoking. The procedure code captures the inpatient administration or modification of bupropion therapy during this elective medical admission. Typical codes: HZ97ZZZ

ICD-10-PCS Code For Nicotine Replacement: Procedure Code Group Overview

HZ91-METHADONE-MAINTENANCE-PHARMACOTHERAPY

ICD-10-PCS Code for Methadone Maintenance: Procedure Code Group Overview

HZ92-LEVO-ALPHA-ACETYL-METHADOL-PHARMACOTHERAPY

ICD-10-PCS Code For Levo Alpha Acetyl Methadol: Procedure Code Group Overview

HZ93-ANTABUSE-PHARMACOTHERAPY

ICD-10-PCS Code For Antabuse: Procedure Code Group Overview

HZ94-NALTREXONE-PHARMACOTHERAPY

ICD-10-PCS Code For Naltrexone: Procedure Code Group Overview

HZ95-NALOXONE-ALTERATION

ICD-10-PCS Code For Naloxone: Procedure Code Group Overview

HZ96-CLONIDINE-PHARMACOTHERAPY

ICD-10-PCS Code For Clonidine: Procedure Code Group Overview

HZ98-PSYCHIATRIC-MEDICATION-PHARMACOTHERAPY

ICD-10-PCS Code For Psychiatric Medication: Procedure Code Group Overview

HZ99-OTHER-REPLACEMENT-MEDICATION-PHARMACOTHERAPY

ICD-10-PCS Code For Other Replacement Medication: Procedure Code Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

ICD-10-PCS Code For Bupropion: Procedure Code Group Overview

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Bupropion Pharmacotherapy Procedure Overview

Code Attributes

OpenPayer

ICD-10-PCS Code For Bupropion: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Bupropion: Procedure Code Group Overview policy alerts

Bupropion Pharmacotherapy Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-PCS Code For Bupropion: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Bupropion: Procedure Code Group Overview policy alerts

Bupropion Pharmacotherapy Procedure Overview

Code Attributes

ICD-10-PCS Code For Bupropion: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Bupropion: Procedure Code Group Overview policy alerts

Bupropion Pharmacotherapy Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-PCS code captures inpatient bupropion pharmacotherapy for substance abuse treatment?

What is the purpose of using `HZ97ZZZ` in inpatient documentation?

Under which ICD-10-PCS section and operation does bupropion pharmacotherapy fall?

Does the code group HZ97 include multiple body parts or drugs?

How does accurate coding of `HZ97ZZZ` impact reimbursement and records?

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-PCS code captures inpatient bupropion pharmacotherapy for substance abuse treatment?

What is the purpose of using `HZ97ZZZ` in inpatient documentation?

Under which ICD-10-PCS section and operation does bupropion pharmacotherapy fall?

Does the code group HZ97 include multiple body parts or drugs?

How does accurate coding of `HZ97ZZZ` impact reimbursement and records?

References