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    v1.0.30
    OpenPayerBilling CodesMetabolic disordersICD-10-CM e85-amyloidosis
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    ICD-10-CM Code For Amyloidosis: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group E85 includes systemic and localized amyloidosis diagnoses characterized by extracellular deposition of insoluble protein fibrils, specifying organ involvement such as cardiac, renal, neurologic, or hepatic manifestations. These ICD-10-CM diagnosis codes are used to document clinical scenarios that capture disease distribution, organ dysfunction, and severity, including distinctions between light-chain, hereditary, secondary, and localized forms. Accurate coding within the ICD-10-CM E85 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM E85: Amyloidosis Overview

    The ICD-10-CM E85 amyloidosis group represents disorders characterized by extracellular deposition of misfolded protein fibrils affecting one or multiple organs. These conditions can involve the heart, kidneys, liver, nervous system, and gastrointestinal tract leading to organ dysfunction. Accurate coding matters because it captures organ involvement and disease severity, which supports complete clinical documentation and appropriate reimbursement.

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    When to Use

    Use a code from this group when documentation indicates amyloid deposition with specification of type or affected organs, or when clinical findings and diagnostic testing confirm amyloidosis. Select codes that reflect the specific etiology and organ system involvement documented in the medical record.

    ICD-10-CM Codes

    9 rows

    ICD-10-CM CodeDescription
    E85.0Non-neuropathic heredofamilial amyloidosis
    E85.1Neuropathic heredofamilial amyloidosis
    E85.2Heredofamilial amyloidosis, unspecified
    E85.3Secondary systemic amyloidosis
    E85.4Organ-limited amyloidosis
    E85.81Light chain (AL) amyloidosis
    E85.82Wild-type transthyretin-related (ATTR) amyloidosis
    E85.89Other amyloidosis
    E85.9Amyloidosis, unspecified

    DRG Codes

    3 rows

    DRG CodeDescription
    545Connective Tissue Disorders with MCC
    546Connective Tissue Disorders with CC
    547Connective Tissue Disorders without CC/MCC

    Typical Clinical Scenarios

    • An elderly patient presents to the emergency department with acute onset of progressive dyspnea, orthopnea, peripheral edema, and signs of congestive heart failure. Echocardiogram shows restrictive cardiomyopathy with thickened ventricular walls and low-voltage ECG; serum and urine protein electrophoresis reveal a monoclonal light chain. A diagnosis from this group is assigned to indicate cardiac involvement by systemic light-chain amyloid disease. Typical codes: E85.81, E85.82
    • A middle-aged patient with longstanding paresthesias, progressive distal symmetric sensorimotor polyneuropathy, and autonomic dysfunction (orthostatic hypotension, gastrointestinal motility problems) is referred for evaluation; nerve biopsy demonstrates amyloid deposits and genetic testing confirms transthyretin mutation in a familial case. A code from this group is used to capture hereditary amyloid neuropathy as the underlying metabolic disorder causing chronic neurologic decline. Typical codes: E85.1, E85.2
    • A hospitalized patient with chronic kidney disease is noted to have nephrotic-range proteinuria and declining renal function; renal biopsy identifies amyloid deposition in glomeruli without clear systemic monoclonal gammopathy on initial workup. A diagnosis from this group is assigned to document renal involvement by amyloidosis as a comorbidity complicating management of the patients renal disease. Typical codes: E85.3, E85.9}

    Related Codes

    E70-DISORDERS-OF-AROMATIC-AMINO-ACID-METABOLISM

    ICD-10-CM Code For Disorders Of Aromatic Amino-Acid Metabolism: Group Overview

    E71-DISORDERS-OF-BRANCHED-CHAIN-AMINO-ACID-METABOLISM

    ICD-10-CM Code For Disorders Of Branched Chain Amino Acid Metabolism And Fatty Acid Metabolism: Group Overview

    E72-OTHER-DISORDERS-OF-AMINO-ACID-METABOLISM

    ICD-10-CM Code For Other Disorders Of Amino-Acid Metabolism: Group Overview

    E73-LACTOSE-INTOLERANCE

    ICD-10-CM Code For Lactose Intolerance: Group Overview

    E74-OTHER-DISORDERS-OF-CARBOHYDRATE-METABOLISM

    ICD-10-CM Code For Other Disorders Of Carbohydrate Metabolism: Group Overview

    E75-DISORDERS-OF-SPHINGOLIPID-METABOLISM

    ICD-10-CM Code For Disorders Of Sphingolipid Metabolism And Other Lipid Storage Disorders: Group Overview

    E76-DISORDERS-OF-GLYCOSAMINOGLYCAN-METABOLISM

    ICD-10-CM Code For Disorders Of Glycosaminoglycan Metabolism: Group Overview

    E77-DISORDERS-OF-GLYCOPROTEIN-METABOLISM

    ICD-10-CM Code For Disorders Of Glycoprotein Metabolism: Group Overview

    E78-DISORDERS-OF-LIPOPROTEIN-METABOLISM

    ICD-10-CM Code For Disorders Of Lipoprotein Metabolism And Other Lipidemias: Group Overview

    E79-DISORDERS-OF-PURINE-AND-PYRIMIDINE-METABOLISM

    ICD-10-CM Code For Disorders Of Purine And Pyrimidine Metabolism: Group Overview

    Showing 1–10 of 16

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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