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    OpenPayerBilling CodesMetabolic disordersICD-10-CM e72-other-disorders-of-amino-acid-metabolism
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    ICD-10-CM Code For Other Disorders Of Amino-Acid Metabolism: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group E72 includes inherited and acquired disorders of amino-acid metabolism such as hyperphenylalaninemia, disorders of branched-chain amino-acid metabolism, and other specified amino-acidurias that can present with neurologic, hepatic, or systemic manifestations. These ICD-10-CM diagnosis codes are used to document clinical scenarios ranging from newborn metabolic screening abnormalities to late-onset metabolic decompensation, capturing disease severity, organ involvement, or clinical complexity relevant to this group. Accurate coding within the ICD-10-CM E72 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM E72: Other Disorders Of Amino-Acid Metabolism Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification ICD-10-CM E72 group covers inherited and acquired disorders of amino-acid metabolism that affect biochemical pathways producing or degrading amino acids. These conditions primarily target metabolic and hepatic systems, with potential multisystem effects including neurologic, renal, and developmental manifestations. Accurate coding matters because it supports complete clinical documentation and aligns diagnosis reporting with reimbursement and care coordination requirements.

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    When to Use

    Use a code from this group when a documented diagnosis indicates a specific disorder of amino-acid metabolism identified by clinical evaluation, laboratory testing, or genetic testing. Codes from this group are appropriate for encounters describing initial diagnosis, ongoing management, complications, or sequelae related to these metabolic conditions.

    ICD-10-CM Codes

    31 rows

    ICD-10-CM CodeDescription
    E72.00Disorders of amino-acid transport, unspecified
    E72.01Cystinuria
    E72.02Hartnup's disease
    E72.03Lowe's syndrome
    E72.04Cystinosis
    E72.09Other disorders of amino-acid transport
    E72.10Disorders of sulfur-bearing amino-acid metabolism, unspecified
    E72.11Homocystinuria
    E72.12Methylenetetrahydrofolate reductase deficiency
    E72.19Other disorders of sulfur-bearing amino-acid metabolism
    E72.20Disorder of urea cycle metabolism, unspecified
    E72.21Argininemia
    E72.22Arginosuccinic aciduria
    E72.23Citrullinemia
    E72.29Other disorders of urea cycle metabolism
    E72.3Disorders of lysine and hydroxylysine metabolism
    E72.4Disorders of ornithine metabolism
    E72.50Disorder of glycine metabolism, unspecified
    E72.51Non-ketotic hyperglycinemia
    E72.52Trimethylaminuria

    Showing 1–20 of 31

    DRG Codes

    3 rows

    DRG CodeDescription
    642Inborn and Other Disorders of Metabolism
    695Kidney and Urinary Tract Signs and Symptoms with MCC
    696Kidney and Urinary Tract Signs and Symptoms without MCC

    Typical Clinical Scenarios

    • An infant born after an uneventful pregnancy presents in the neonatal period with poor feeding, vomiting, lethargy, and progressive hypotonia; newborn screening and plasma amino acid analysis reveal marked hyperammonemia and elevated glutamine, suggesting an inherited disorder of amino acid catabolism. The neonate is admitted to the NICU for metabolic stabilization and confirmatory metabolic/genetic testing; a diagnosis from this group is assigned to specify the underlying amino-acid metabolic defect causing neonatal hyperammonemia. Typical codes: E72.0, E72.10
    • A young child with developmental delay and new-onset seizures is evaluated by neurology after brain MRI shows white matter changes; biochemical testing demonstrates elevated branched-chain amino acids, consistent with a chronic branched-chain amino acid metabolism disorder requiring long-term dietary management and specialty follow-up. The diagnosis from this group is used to document the chronic inherited amino-acid metabolic condition as the primary neurologic comorbidity driving care planning and therapy. Typical codes: E72.20, E72.21
    • An adult with progressive cognitive decline and movement disorder is hospitalized for worsening gait instability; metabolic workup uncovers abnormal amino-acid profiles and a previously undiagnosed adult-onset amino-acid metabolism disorder presenting as a complication of liver dysfunction. A code from this group is assigned to capture the underlying metabolic etiology contributing to the patient’s neuropsychiatric and hepatic comorbidities. Typical codes: E72.89, E72.9}

    Related Codes

    E70-DISORDERS-OF-AROMATIC-AMINO-ACID-METABOLISM

    ICD-10-CM Code For Disorders Of Aromatic Amino-Acid Metabolism: Group Overview

    E71-DISORDERS-OF-BRANCHED-CHAIN-AMINO-ACID-METABOLISM

    ICD-10-CM Code For Disorders Of Branched Chain Amino Acid Metabolism And Fatty Acid Metabolism: Group Overview

    E73-LACTOSE-INTOLERANCE

    ICD-10-CM Code For Lactose Intolerance: Group Overview

    E74-OTHER-DISORDERS-OF-CARBOHYDRATE-METABOLISM

    ICD-10-CM Code For Other Disorders Of Carbohydrate Metabolism: Group Overview

    E75-DISORDERS-OF-SPHINGOLIPID-METABOLISM

    ICD-10-CM Code For Disorders Of Sphingolipid Metabolism And Other Lipid Storage Disorders: Group Overview

    E76-DISORDERS-OF-GLYCOSAMINOGLYCAN-METABOLISM

    ICD-10-CM Code For Disorders Of Glycosaminoglycan Metabolism: Group Overview

    E77-DISORDERS-OF-GLYCOPROTEIN-METABOLISM

    ICD-10-CM Code For Disorders Of Glycoprotein Metabolism: Group Overview

    E78-DISORDERS-OF-LIPOPROTEIN-METABOLISM

    ICD-10-CM Code For Disorders Of Lipoprotein Metabolism And Other Lipidemias: Group Overview

    E79-DISORDERS-OF-PURINE-AND-PYRIMIDINE-METABOLISM

    ICD-10-CM Code For Disorders Of Purine And Pyrimidine Metabolism: Group Overview

    E80-DISORDERS-OF-PORPHYRIN-AND-BILIRUBIN-METABOLISM

    ICD-10-CM Code For Disorders Of Porphyrin And Bilirubin Metabolism: Group Overview

    Showing 1–10 of 16

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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