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    v1.0.28
    OpenPayerBilling CodesMetabolic disordersICD-10-CM e77-disorders-of-glycoprotein-metabolism
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    ICD-10-CM Code For Disorders Of Glycoprotein Metabolism: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group E77 includes inherited and acquired disorders of glycoprotein metabolism such as congenital glycosylation defects, sialidosis, and other glycoprotein processing abnormalities that can affect multiple organ systems. These ICD-10-CM diagnosis codes are used to document a range of clinical scenarios including multisystem involvement, neurologic impairment, developmental delay, and progressive organ dysfunction, capturing disease severity and complexity. Accurate coding within the ICD-10-CM E77 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM E77: Disorders Of Glycoprotein Metabolism Overview

    The disorders in this group represent inherited or acquired abnormalities in glycoprotein synthesis, processing, or degradation that affect multiple organ systems, often including the liver, nervous system, and skeletal system. These conditions target metabolic pathways involving glycoproteins and can present with developmental, neurologic, or systemic features. Accurate coding matters for reimbursement because it ensures clinical complexity and specific diagnoses are documented for appropriate claim adjudication.

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    When to Use

    Use a code from this group when a documented diagnosis identifies a disorder of glycoprotein metabolism confirmed by clinical, biochemical, genetic, or enzymatic testing. Select the most specific code that reflects the exact diagnosis, associated manifestations, and any documented severity or complications.

    ICD-10-CM Codes

    4 rows

    ICD-10-CM CodeDescription
    E77.0Defects in post-translational modification of lysosomal enzymes
    E77.1Defects in glycoprotein degradation
    E77.8Other disorders of glycoprotein metabolism
    E77.9Disorder of glycoprotein metabolism, unspecified

    DRG Codes

    1 rows

    DRG CodeDescription
    642Inborn and Other Disorders of Metabolism

    Typical Clinical Scenarios

    • An infant presents to pediatrics with hypotonia, failure to thrive, recurrent infections, and developmental delay. Newborn metabolic workup and enzymatic studies reveal a congenital defect in glycoprotein processing consistent with a hereditary disorder of glycoprotein metabolism; genetic testing confirms a congenital disorder of glycosylation. A diagnosis from this group is assigned to capture the inherited glycoprotein processing disorder and guide further genetic counseling and specialty care. Typical codes: E77.0, E77.1
    • An adult with long-standing liver disease is evaluated for progressive cholestasis, steatorrhea, and coagulopathy; biochemical testing and liver biopsy show abnormal glycoprotein synthesis contributing to the hepatic dysfunction. The patient is seen in hepatology for worsening chronic metabolic complications related to impaired glycoprotein metabolism, and a code from this group is used to document the underlying metabolic disorder as a chronic comorbidity affecting management. Typical codes: E77.8, E77.9
    • A child with a previously diagnosed glycoprotein metabolism disorder is brought to the emergency department with acute respiratory distress and rapid clinical deterioration from aspiration pneumonia and sepsis. The acute infectious complication is the reason for the ED visit, while the known inherited glycoprotein disorder is coded as an important contributing condition that predisposed to the severe infectious complication. Typical codes: E77.0, E77.9

    Related Codes

    E70-DISORDERS-OF-AROMATIC-AMINO-ACID-METABOLISM

    ICD-10-CM Code For Disorders Of Aromatic Amino-Acid Metabolism: Group Overview

    E71-DISORDERS-OF-BRANCHED-CHAIN-AMINO-ACID-METABOLISM

    ICD-10-CM Code For Disorders Of Branched Chain Amino Acid Metabolism And Fatty Acid Metabolism: Group Overview

    E72-OTHER-DISORDERS-OF-AMINO-ACID-METABOLISM

    ICD-10-CM Code For Other Disorders Of Amino-Acid Metabolism: Group Overview

    E73-LACTOSE-INTOLERANCE

    ICD-10-CM Code For Lactose Intolerance: Group Overview

    E74-OTHER-DISORDERS-OF-CARBOHYDRATE-METABOLISM

    ICD-10-CM Code For Other Disorders Of Carbohydrate Metabolism: Group Overview

    E75-DISORDERS-OF-SPHINGOLIPID-METABOLISM

    ICD-10-CM Code For Disorders Of Sphingolipid Metabolism And Other Lipid Storage Disorders: Group Overview

    E76-DISORDERS-OF-GLYCOSAMINOGLYCAN-METABOLISM

    ICD-10-CM Code For Disorders Of Glycosaminoglycan Metabolism: Group Overview

    E78-DISORDERS-OF-LIPOPROTEIN-METABOLISM

    ICD-10-CM Code For Disorders Of Lipoprotein Metabolism And Other Lipidemias: Group Overview

    E79-DISORDERS-OF-PURINE-AND-PYRIMIDINE-METABOLISM

    ICD-10-CM Code For Disorders Of Purine And Pyrimidine Metabolism: Group Overview

    E80-DISORDERS-OF-PORPHYRIN-AND-BILIRUBIN-METABOLISM

    ICD-10-CM Code For Disorders Of Porphyrin And Bilirubin Metabolism: Group Overview

    Showing 1–10 of 16

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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