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    v1.0.28
    OpenPayerBilling CodesMetabolic disordersICD-10-CM e79-disorders-of-purine-and-pyrimidine-metabolism
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    ICD-10-CM Code For Disorders Of Purine And Pyrimidine Metabolism: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group E79 includes metabolic disorders of purine and pyrimidine metabolism such as hyperuricemia, disorders of purine and pyrimidine metabolism, and related enzymatic deficiencies that can present with gout, kidney stones, or neurologic manifestations. These ICD-10-CM diagnosis codes are used to document specific metabolic abnormalities, disease severity, organ involvement, and biochemical complications relevant to this group. Accurate coding within the ICD-10-CM E79 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM E79: Disorders Of Purine And Pyrimidine Metabolism Overview

    The ICD-10-CM E79 group includes inherited and acquired disorders of purine and pyrimidine metabolism that affect nucleotide synthesis and breakdown, often leading to systemic manifestations such as gout, hyperuricemia, or neurologic symptoms. These conditions target metabolic pathways and can impact multiple organ systems including renal and musculoskeletal systems. Accurate coding is important for complete clinical documentation and appropriate reimbursement for services related to metabolic evaluation and management.

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    When to Use

    Use a code from this group when a documented metabolic disorder of purine or pyrimidine metabolism is the reason for the encounter or significantly impacts care. Codes in this group are appropriate when laboratory, clinical, or specialist documentation identifies specific metabolic abnormalities or related complications.

    ICD-10-CM Codes

    7 rows

    ICD-10-CM CodeDescription
    E79.0Hyperuricemia without signs of inflammatory arthritis and tophaceous disease
    E79.1Lesch-Nyhan syndrome
    E79.2Myoadenylate deaminase deficiency
    E79.81Aicardi-Goutieres syndrome
    E79.82Hereditary xanthinuria
    E79.89Other specified disorders of purine and pyrimidine metabolism
    E79.9Disorder of purine and pyrimidine metabolism, unspecified

    DRG Codes

    3 rows

    DRG CodeDescription
    642Inborn and Other Disorders of Metabolism
    947Signs and Symptoms with MCC
    948Signs and Symptoms without MCC

    Typical Clinical Scenarios

    • An adult presents to the emergency department with sudden-onset severe joint pain, erythema, and swelling of the first metatarsophalangeal joint after a night of alcohol consumption and a fatty meal. Laboratory testing shows markedly elevated serum uric acid and synovial fluid analysis demonstrates needle-shaped, negatively birefringent crystals consistent with acute gout flare; a diagnosis from this group is assigned to capture the disorder of purine metabolism causing hyperuricemia and acute gouty arthritis. Typical codes: E79.0, E79.2
    • A pediatric patient is evaluated in metabolic genetics clinic for developmental delay, failure to thrive, recurrent vomiting, and abnormal urine organic acid profile; enzyme testing reveals orotic aciduria due to a defect in pyrimidine synthesis. The chronic inherited disorder of pyrimidine metabolism is documented to guide long-term management and genetic counseling, so a specific inborn error code from this group is assigned. Typical codes: E79.81, E79.82
    • A hospitalized patient with chronic kidney disease develops persistent hyperuricemia as an incidental lab finding and has a history of tophi and chronic gouty arthropathy contributing to decreased mobility and frequent joint infections. The purine metabolism disorder is coded as a comorbidity to explain the hyperuricemia and its complications impacting hospital care and discharge planning. Typical codes: E79.0, E79.9

    Related Codes

    E70-DISORDERS-OF-AROMATIC-AMINO-ACID-METABOLISM

    ICD-10-CM Code For Disorders Of Aromatic Amino-Acid Metabolism: Group Overview

    E71-DISORDERS-OF-BRANCHED-CHAIN-AMINO-ACID-METABOLISM

    ICD-10-CM Code For Disorders Of Branched Chain Amino Acid Metabolism And Fatty Acid Metabolism: Group Overview

    E72-OTHER-DISORDERS-OF-AMINO-ACID-METABOLISM

    ICD-10-CM Code For Other Disorders Of Amino-Acid Metabolism: Group Overview

    E73-LACTOSE-INTOLERANCE

    ICD-10-CM Code For Lactose Intolerance: Group Overview

    E74-OTHER-DISORDERS-OF-CARBOHYDRATE-METABOLISM

    ICD-10-CM Code For Other Disorders Of Carbohydrate Metabolism: Group Overview

    E75-DISORDERS-OF-SPHINGOLIPID-METABOLISM

    ICD-10-CM Code For Disorders Of Sphingolipid Metabolism And Other Lipid Storage Disorders: Group Overview

    E76-DISORDERS-OF-GLYCOSAMINOGLYCAN-METABOLISM

    ICD-10-CM Code For Disorders Of Glycosaminoglycan Metabolism: Group Overview

    E77-DISORDERS-OF-GLYCOPROTEIN-METABOLISM

    ICD-10-CM Code For Disorders Of Glycoprotein Metabolism: Group Overview

    E78-DISORDERS-OF-LIPOPROTEIN-METABOLISM

    ICD-10-CM Code For Disorders Of Lipoprotein Metabolism And Other Lipidemias: Group Overview

    E80-DISORDERS-OF-PORPHYRIN-AND-BILIRUBIN-METABOLISM

    ICD-10-CM Code For Disorders Of Porphyrin And Bilirubin Metabolism: Group Overview

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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