CPT 81382: HLA High-Resolution Molecular Typing, One Class II Locus
CPT code 81382 represents the technical laboratory component for high-resolution molecular typing of human leukocyte antigen (HLA) genes for one Class II locus. High-resolution HLA typing is critical for transplant compatibility assessment, donor selection, and certain immunogenetic evaluations; standardized coding supports billing, quality measurement, and national reporting of complex molecular diagnostics.
Key payers included in the analysis are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find clinical context about the service type and typical site of service, as well as an overview of payer coverage patterns and commonly used modifiers where available. The publication outlines benchmarking and reimbursement context, evolving policy considerations for molecular diagnostics, and operational implications for laboratories performing high-resolution HLA testing.
This summary provides a concise reference for clinicians, laboratory managers, and billing professionals seeking clear information about CPT code 81382, its clinical relevance, and the payer landscape at a national level. Data not available in the input is noted where applicable in the full publication.
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Billing Code Overview
CPT code 81382 describes a technical laboratory procedure that performs a high-resolution molecular assessment of human leukocyte antigen (HLA) genes for one Class II locus. The procedure uses molecular techniques to generate detailed HLA typing information at the allele level for a single Class II locus.
Service type: Laboratory — high-resolution molecular HLA typing (technical component)
Typical site of service: Clinical laboratory or specialized molecular diagnostics laboratory