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    v1.0.30
    OpenPayerBilling CodesHLA TypingCPT cpt-81374-hla-class-i-low-intermediate-resolution
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    CPT 81374: HLA Class I Allele Group Typing, Low/Intermediate Resolution

    CPT code 81374 describes a laboratory technical assay for low- or intermediate-resolution typing of a single human leukocyte antigen (HLA) Class I allele group, performed by a lab analyst; the service type is a molecular/serologic HLA typing test and the typical site of service is an outpatient clinical laboratory or specialized histocompatibility laboratory.

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 34-year-old adult with a history of recurrent transplant rejection evaluation is referred for HLA typing to determine suitability for organ transplantation and to identify donor–recipient compatibility. The clinician orders a low- or intermediate-resolution HLA class I allele group assay when preliminary HLA antigen group information is needed quickly for listing or for initial donor matching. A phlebotomy draw is performed in an outpatient blood draw center affiliated with a transplant center or hospital laboratory. The specimen is processed in a molecular immunogenetics laboratory where a technologist performs the technical portion of the assay, generating results for one Class I antigen equivalent (allele group of interest). The technical lab report is routed to the ordering transplant physician or transplant coordinator, who integrates the HLA result with clinical history, serologic testing, and, if required, higher-resolution typing or crossmatch testing. Typical sites of service include hospital clinical laboratories, independent reference laboratories, and transplant center laboratories. Workflow steps: obtain informed consent when required, collect specimen, accession and process sample, run HLA low/intermediate resolution assay for one Class I antigen equivalent, validate technical run, report results to ordering provider, and archive raw data according to laboratory policy.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    0000F(Placeholder)Data not available in the input.
    86255Legionella antibody; immunoassay for IgG or IgMData not available in the input.
    88305Level IV surgical pathology, gross and microscopic examinationData not available in the input.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    208M00000X
    103TP2701X
    282E00000X
    246QC1000X
    247000000X
    207RA0002X
    1835C0207X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    A15.0Tuberculosis of lung
    B20Human immunodeficiency virus [HIV] disease
    C44.91Basal cell carcinoma of skin, unspecified
    D47.Z2Castleman disease
    D86.0Sarcoidosis of lung
    J84.10Pulmonary fibrosis, unspecified
    K50.919Crohn's disease, unspecified, with unspecified complications
    K51.90Ulcerative colitis, unspecified, without complications
    L93.0Discoid lupus erythematosus
    M32.9Systemic lupus erythematosus, unspecified

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Carrier Testing Panels for Genetic Diseases (for Kentucky Only)UnitedHealthcare2026-10-01
    Genetic Testing for Neurological Disorders (for Kansas Only)UnitedHealthcare2026-10-01
    Genetic and Molecular TestingProvidence Health Plan2026-10-01
    Cell-Free Fetal DNA Testing (for Idaho Only)UnitedHealthcare2026-10-01
    Next Generation Sequencing for Minimal Residual Disease DetectionProvidence Health Plan2026-10-01
    Pharmacogenetic Panel Testing (for Kansas Only)UnitedHealthcare2026-10-01
    Non-Covered Genetic Panel TestsProvidence Health Plan2026-10-01

    Related Codes

    CPT-81370-HLA-CLASS-I-II-LOW-INTERMEDIATE-RESOLUTION-TESTING

    CPT 81370: HLA Class I and II Low/Intermediate Resolution Typing

    CPT-81371-HLA-A-B-DRB1-LOW-INTERMEDIATE-RESOLUTION-TYPING

    CPT 81371: Low/Intermediate-Resolution HLA-A, -B, and -DRB1 Typing

    CPT-81372-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION-TYPING

    CPT 81372: HLA Class I Low/Intermediate Resolution Typing

    CPT-81373-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION

    CPT 81373: HLA Typing, Low or Intermediate Resolution, One Class I Locus

    CPT-81375-HLA-CLASS-II-LOW-INTERMEDIATE-RESOLUTION-TYPING

    CPT 81375: HLA Class II Low/Intermediate-Resolution Molecular Typing

    CPT-81376-HLA-CLASS-II-TYPING-LOW-INTERMEDIATE-RESOLUTION-TECHNICAL

    CPT 81376: HLA Class II Low/Intermediate Resolution, Technical Test

    CPT-81377-HLA-CLASS-II-ALLELE-GROUP-TYPING-LOW-INTERMEDIATE-RESOLUTION

    CPT 81377: HLA Class II Allele Group Typing, Low/Intermediate Resolution

    CPT-81378-HLA-HIGH-RESOLUTION-MOLECULAR-TYPING-CLASS-I-II-DRB1

    CPT 81378: High-Resolution HLA Class I and II Typing

    CPT-81379-HLA-CLASS-I-HIGH-RESOLUTION-TYPING

    CPT 81379: HLA Class I High-Resolution Molecular Typing

    CPT-81380-HLA-HIGH-RESOLUTION-CLASS-I-TYPING

    CPT 81380: HLA High-Resolution Molecular Typing, One Class I Locus

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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