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    OpenPayerBilling CodesHLA TypingCPT cpt-81376-hla-class-ii-typing-low-intermediate-resolution-technical
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    CPT 81376: HLA Class II Low/Intermediate Resolution, Technical Test

    CPT code 81376 describes a laboratory technical test using molecular techniques to perform a low- or intermediate-resolution assessment of human leukocyte antigen (HLA) genes for a single Class II locus; this service is a molecular pathology/genetic testing procedure typically performed in a clinical laboratory or molecular diagnostics facility and billed as the laboratory technical component.

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.

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    Clinical & Coding Specifications

    Clinical Context

    A 32-year-old patient evaluated for kidney transplantation is referred for HLA typing to assess donor-recipient compatibility. The ordering clinician is a transplant nephrologist who requests low- or intermediate-resolution molecular testing of a single Class II HLA locus (for example HLA-DR or HLA-DQ) to inform panel reactive antibody interpretation and organ allocation. A phlebotomy nurse collects a peripheral blood sample and sends it with the requisition to the molecular diagnostics laboratory. The laboratory technologist performs nucleic acid extraction and runs the appropriate molecular assay for 81376 (low/intermediate resolution assessment of one Class II locus). Results are reviewed and finalized by a qualified laboratory director, and the report is returned to the transplant team. Typical sites of service include an independent clinical molecular laboratory, hospital-based clinical laboratory, or an academic medical center molecular diagnostics lab. The service is technical in nature and is billed for the laboratory test component of HLA Class II typing using molecular techniques.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    86850Tissue typing; HLA antibody, lymphocytotoxic (assay)Serologic HLA antibody testing often performed in parallel with molecular HLA typing for transplant compatibility assessment.
    86821Crossmatch, lymphocytotoxic, non-donor specific antibody (complement-dependent)Crossmatch studies are performed as part of pre-transplant compatibility testing alongside HLA typing.
    81479Unlisted molecular pathology procedureUsed when testing falls outside defined molecular CPT codes or for novel/expanded HLA assays not captured by 81376.
    88381Consultation and laboratory oversight (interpretation)Pathologist or laboratory director interpretation and supervision related to molecular testing results.
    36415Collection of venous blood by venipunctureSpecimen collection code commonly billed or documented when obtaining sample for HLA molecular testing.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207L00000X
    208000000X
    208100000X
    1223X0400X
    261QM1100X
    207SM0001X
    225XG0600X

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    B20Human immunodeficiency virus [HIV] disease
    D47.Z2Castleman disease
    D84.9Immunodeficiency, unspecified
    D86.0Sarcoidosis of lung
    L93.0Discoid lupus erythematosus
    M13.0Polyarthritis, unspecified
    N39.0Urinary tract infection, site not specified
    R50.9Fever, unspecified
    T86.10Unspecified complication of kidney transplant

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Carrier Testing Panels for Genetic Diseases (for Kentucky Only)UnitedHealthcare2026-10-01
    Genetic Testing for Neurological Disorders (for Kansas Only)UnitedHealthcare2026-10-01
    Genetic and Molecular TestingProvidence Health Plan2026-10-01
    Cell-Free Fetal DNA Testing (for Idaho Only)UnitedHealthcare2026-10-01
    Next Generation Sequencing for Minimal Residual Disease DetectionProvidence Health Plan2026-10-01
    Pharmacogenetic Panel Testing (for Kansas Only)UnitedHealthcare2026-10-01
    Non-Covered Genetic Panel TestsProvidence Health Plan2026-10-01

    Related Codes

    CPT-81370-HLA-CLASS-I-II-LOW-INTERMEDIATE-RESOLUTION-TESTING

    CPT 81370: HLA Class I and II Low/Intermediate Resolution Typing

    CPT-81371-HLA-A-B-DRB1-LOW-INTERMEDIATE-RESOLUTION-TYPING

    CPT 81371: Low/Intermediate-Resolution HLA-A, -B, and -DRB1 Typing

    CPT-81372-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION-TYPING

    CPT 81372: HLA Class I Low/Intermediate Resolution Typing

    CPT-81373-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION

    CPT 81373: HLA Typing, Low or Intermediate Resolution, One Class I Locus

    CPT-81374-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION

    CPT 81374: HLA Class I Allele Group Typing, Low/Intermediate Resolution

    CPT-81375-HLA-CLASS-II-LOW-INTERMEDIATE-RESOLUTION-TYPING

    CPT 81375: HLA Class II Low/Intermediate-Resolution Molecular Typing

    CPT-81377-HLA-CLASS-II-ALLELE-GROUP-TYPING-LOW-INTERMEDIATE-RESOLUTION

    CPT 81377: HLA Class II Allele Group Typing, Low/Intermediate Resolution

    CPT-81378-HLA-HIGH-RESOLUTION-MOLECULAR-TYPING-CLASS-I-II-DRB1

    CPT 81378: High-Resolution HLA Class I and II Typing

    CPT-81379-HLA-CLASS-I-HIGH-RESOLUTION-TYPING

    CPT 81379: HLA Class I High-Resolution Molecular Typing

    CPT-81380-HLA-HIGH-RESOLUTION-CLASS-I-TYPING

    CPT 81380: HLA High-Resolution Molecular Typing, One Class I Locus

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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