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CPT 81370: HLA Class I and II Low/Intermediate-Resolution Molecular Typing

CPT code 81370 denotes a laboratory technical service for low- or intermediate-resolution molecular typing of human leukocyte antigen (HLA) genes covering Class I (HLA–A, HLA–B, HLA–C) and Class II (HLA–DRB1, HLA–DRB3/4/5, HLA–DQB1). This test supports transplantation matching, immunogenetics evaluation, and select diagnostic workups where HLA typing informs clinical decisions. Nationally, standardized coding for HLA molecular testing matters for consistent reporting, claims processing, and aggregate monitoring of transplant-related services.

Key payers included in the analysis are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the clinical scope and service setting for the code, discussion of common billing considerations, and pointers to areas typically reviewed in coverage and reimbursement assessments such as technical component reporting and laboratory site of service. The publication covers benchmarking concepts, policy update considerations relevant to molecular HLA testing, and clinical context for when low- or intermediate-resolution typing is used. Data not available in the input are noted where applicable.

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Billing Code Overview

CPT code 81370 describes a laboratory technical service for low- or intermediate-resolution molecular assessment of human leukocyte antigen (HLA) genes for Classes I and II. HLA Class I in this test includes HLA–A, HLA–B, and HLA–C. HLA Class II for this test includes HLA–DRB1, HLA–DRB3/4/5, and HLA–DQB1.

Service type: Laboratory molecular testing (technical component)

Typical site of service: Clinical laboratory or reference laboratory

Data not available in the input for associated taxonomies, ICD-10 diagnoses, and related codes.

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CPT 81370: HLA Class I and II Low/Intermediate-Resolution Molecular Typing

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Billing Code Overview

Service type: Laboratory molecular testing (technical component)

Typical site of service: Clinical laboratory or reference laboratory

Data not available in the input for associated taxonomies, ICD-10 diagnoses, and related codes.

Clinical & Coding Specifications

Clinical Context

A typical patient is a transplant candidate or recipient undergoing immunogenetic compatibility testing. For example, a 45-year-old patient being evaluated for kidney transplantation has a blood specimen collected in the outpatient lab. The clinical workflow includes: the ordering clinician (nephrologist or transplant coordinator) places an order for HLA typing; the phlebotomy team draws and properly labels the specimen; the specimen is sent to the molecular diagnostics laboratory; a laboratory analyst performs 81370 low or intermediate resolution molecular HLA Class I (HLA–A, –B, –C) and Class II (HLA–DRB1, –DRB3/4/5, –DQB1) testing; results are reviewed by laboratory personnel and reported into the electronic medical record; the transplant team uses results for donor–recipient matching and immunologic risk assessment. Typical site of service is an outpatient hospital laboratory, independent clinical molecular diagnostics laboratory, or a hospital-based transfusion/immunology laboratory. The typical service type is laboratory molecular testing using PCR-based or sequence-specific oligonucleotide/primer molecular techniques.

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when reporting only the professional interpretation component if applicable and billable separately.
`TC`	Technical component	Use when billing only the technical component (laboratory processing and analysis).
`59`	Distinct procedural service	Use when an unrelated, separate procedure is performed on the same date and needs to be distinguished.
`90`	Reference (outside) laboratory	Use when the test was performed by an outside independent laboratory.
`91`	Repeat clinical diagnostic test	Use when repeat testing is performed on the same specimen to confirm unexpected results.
`52`	Reduced services	Use when the service is partially reduced or not completed as originally planned.
`53`	Discontinued procedure	Use when the testing process was started but discontinued.
`76`	Repeat procedure or service by same provider	`76` is not listed in input; use `91` instead.
`22`	Increased procedural services	Use when the test required substantially greater resources than typical (rare for standardized lab tests).
`90`	Reference (duplicate)	Duplicate entry avoided; only list once.

Taxonomy Code	Specialty	Notes
2080S0001X	Clinical Molecular Laboratory Specialist	Specialists overseeing molecular HLA testing and result interpretation.
207RC0000X	Clinical Laboratory	Clinical laboratory directors and supervisors responsible for testing quality and compliance.
207L00000X	Clinical Pathology	Pathologists who may review complex immunogenetics results and provide consultative interpretation.
3336C0002X	Transplant Coordinator	Ordering clinicians who manage donor/recipient testing workflow and documentation.
207K00000X	Hematopathology	Laboratory specialists involved when testing intersects with hematology or transplant services.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`Z94.0`	Kidney transplant status	Common in patients undergoing HLA testing for donor matching or post-transplant monitoring.
`Z48.21`	Encounter for aftercare following kidney transplant	HLA testing may be used in surveillance and immunologic assessment.
`Z99.2`	Dependence on renal dialysis	Patients awaiting transplant often undergo HLA typing as part of evaluation.
`Z52.4`	Organ donor status	HLA typing is essential for donor evaluation and registries.
`D68.9`	Coagulation defect, unspecified	Hematologic conditions may necessitate immunogenetic workup in transplant or transfusion settings.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`88381`	Consultation and review of cytogenetic or molecular test results (interpretation)	May be billed when a pathologist or molecular specialist provides a separate, billable interpretation of complex HLA results.
`86152`	Antibody identification, solid phase (e.g., Luminex)	Often performed alongside HLA typing for donor-specific antibody assessment in transplant evaluation.
`87220`	Culture, bacterial; presumptive identification by staining and microscopy	Not directly related to HLA typing; Data not available in the input.
`0000F`	Data not applicable	Data not available in the input.
`81299`	Unlisted molecular pathology procedure	Used when a specific molecular HLA test falls outside established codes and requires an unlisted code.

Note: Related code selection is based on common laboratory and transplant workflows. If specific institutional billing pathways differ, local coding guidance should be consulted.

CPT 81371: HLA-A, HLA-B, HLA-DRB1 Low/Intermediate Resolution Typing

CPT-81372-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION-TYPING

CPT 81372: HLA Class I Low/Intermediate-Resolution Molecular Typing

CPT-81373-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION

CPT 81373: HLA Class I Low/Intermediate Resolution Molecular Test

CPT-81374-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION

CPT 81374: HLA Class I Low/Intermediate-Resolution Testing

CPT-81375-HLA-CLASS-II-LOW-INTERMEDIATE-RESOLUTION-TYPING

CPT 81375: HLA Class II Low/Intermediate-Resolution Molecular Typing

CPT-81376-HLA-CLASS-II-TYPING-LOW-INTERMEDIATE-RESOLUTION-TECHNICAL

CPT 81376: HLA Class II Typing, Low/Intermediate-Resolution Technical

CPT-81377-HLA-CLASS-II-ALLELE-GROUP-TYPING-LOW-INTERMEDIATE-RESOLUTION

CPT 81377: HLA Class II Allele Group Typing, Low/Intermediate Resolution

CPT-81378-HLA-HIGH-RESOLUTION-MOLECULAR-TYPING-CLASS-I-II-DRB1

CPT 81378: High-Resolution HLA Class I and II Molecular Typing

CPT-81379-HLA-CLASS-I-HIGH-RESOLUTION-TYPING

CPT 81379: High-Resolution HLA Class I Typing

CPT-81380-HLA-HIGH-RESOLUTION-CLASS-I-TYPING

CPT 81380: High-Resolution HLA Class I Molecular Typing

Showing 1–10 of 13

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when reporting only the professional interpretation component if applicable and billable separately.
`TC`	Technical component	Use when billing only the technical component (laboratory processing and analysis).
`59`	Distinct procedural service	Use when an unrelated, separate procedure is performed on the same date and needs to be distinguished.
`90`	Reference (outside) laboratory	Use when the test was performed by an outside independent laboratory.
`91`	Repeat clinical diagnostic test	Use when repeat testing is performed on the same specimen to confirm unexpected results.
`52`	Reduced services	Use when the service is partially reduced or not completed as originally planned.
`53`	Discontinued procedure	Use when the testing process was started but discontinued.
`76`	Repeat procedure or service by same provider	`76` is not listed in input; use `91` instead.
`22`	Increased procedural services	Use when the test required substantially greater resources than typical (rare for standardized lab tests).
`90`	Reference (duplicate)	Duplicate entry avoided; only list once.

Taxonomy Code	Specialty	Notes
2080S0001X	Clinical Molecular Laboratory Specialist	Specialists overseeing molecular HLA testing and result interpretation.
207RC0000X	Clinical Laboratory	Clinical laboratory directors and supervisors responsible for testing quality and compliance.
207L00000X	Clinical Pathology	Pathologists who may review complex immunogenetics results and provide consultative interpretation.
3336C0002X	Transplant Coordinator	Ordering clinicians who manage donor/recipient testing workflow and documentation.
207K00000X	Hematopathology	Laboratory specialists involved when testing intersects with hematology or transplant services.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`Z94.0`	Kidney transplant status	Common in patients undergoing HLA testing for donor matching or post-transplant monitoring.
`Z48.21`	Encounter for aftercare following kidney transplant	HLA testing may be used in surveillance and immunologic assessment.
`Z99.2`	Dependence on renal dialysis	Patients awaiting transplant often undergo HLA typing as part of evaluation.
`Z52.4`	Organ donor status	HLA typing is essential for donor evaluation and registries.
`D68.9`	Coagulation defect, unspecified	Hematologic conditions may necessitate immunogenetic workup in transplant or transfusion settings.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`88381`	Consultation and review of cytogenetic or molecular test results (interpretation)	May be billed when a pathologist or molecular specialist provides a separate, billable interpretation of complex HLA results.
`86152`	Antibody identification, solid phase (e.g., Luminex)	Often performed alongside HLA typing for donor-specific antibody assessment in transplant evaluation.
`87220`	Culture, bacterial; presumptive identification by staining and microscopy	Not directly related to HLA typing; Data not available in the input.
`0000F`	Data not applicable	Data not available in the input.
`81299`	Unlisted molecular pathology procedure	Used when a specific molecular HLA test falls outside established codes and requires an unlisted code.

Note: Related code selection is based on common laboratory and transplant workflows. If specific institutional billing pathways differ, local coding guidance should be consulted.

CPT 81371: HLA-A, HLA-B, HLA-DRB1 Low/Intermediate Resolution Typing

CPT-81372-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION-TYPING

CPT 81372: HLA Class I Low/Intermediate-Resolution Molecular Typing

CPT-81373-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION

CPT 81373: HLA Class I Low/Intermediate Resolution Molecular Test

CPT-81374-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION

CPT 81374: HLA Class I Low/Intermediate-Resolution Testing

CPT-81375-HLA-CLASS-II-LOW-INTERMEDIATE-RESOLUTION-TYPING

CPT 81375: HLA Class II Low/Intermediate-Resolution Molecular Typing

CPT-81376-HLA-CLASS-II-TYPING-LOW-INTERMEDIATE-RESOLUTION-TECHNICAL

CPT 81376: HLA Class II Typing, Low/Intermediate-Resolution Technical

CPT-81377-HLA-CLASS-II-ALLELE-GROUP-TYPING-LOW-INTERMEDIATE-RESOLUTION

CPT 81377: HLA Class II Allele Group Typing, Low/Intermediate Resolution

CPT-81378-HLA-HIGH-RESOLUTION-MOLECULAR-TYPING-CLASS-I-II-DRB1

CPT 81378: High-Resolution HLA Class I and II Molecular Typing

CPT-81379-HLA-CLASS-I-HIGH-RESOLUTION-TYPING

CPT 81379: High-Resolution HLA Class I Typing

CPT-81380-HLA-HIGH-RESOLUTION-CLASS-I-TYPING

CPT 81380: High-Resolution HLA Class I Molecular Typing

Showing 1–10 of 13

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 81370: HLA Class I and II Low/Intermediate-Resolution Molecular Typing

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Billing Code Overview

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CPT 81370: HLA Class I and II Low/Intermediate-Resolution Molecular Typing

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References