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    v1.0.30
    OpenPayerBilling CodesHLA TypingCPT cpt-81370-hla-class-i-ii-low-intermediate-resolution-testing
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    CPT 81370: HLA Class I and II Low/Intermediate Resolution Typing

    CPT code 81370 describes laboratory testing for low- or intermediate-resolution molecular typing of human leukocyte antigen (HLA) genes for HLA Class I (HLA–A, –B, –C) and HLA Class II (HLA–DRB1, –DRB3/4/5, –DQB1); the service is a molecular pathology/genetic testing procedure typically performed as a clinical laboratory service in a hospital lab, reference laboratory, or specialized molecular diagnostics facility to support transplant compatibility assessment, disease association studies, or immune-related clinical evaluations.

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a transplant candidate or recipient undergoing immunogenetic compatibility testing. For example, a 45-year-old patient being evaluated for kidney transplantation has a blood specimen collected in the outpatient lab. The clinical workflow includes: the ordering clinician (nephrologist or transplant coordinator) places an order for HLA typing; the phlebotomy team draws and properly labels the specimen; the specimen is sent to the molecular diagnostics laboratory; a laboratory analyst performs 81370 low or intermediate resolution molecular HLA Class I (HLA–A, –B, –C) and Class II (HLA–DRB1, –DRB3/4/5, –DQB1) testing; results are reviewed by laboratory personnel and reported into the electronic medical record; the transplant team uses results for donor–recipient matching and immunologic risk assessment. Typical site of service is an outpatient hospital laboratory, independent clinical molecular diagnostics laboratory, or a hospital-based transfusion/immunology laboratory. The typical service type is laboratory molecular testing using PCR-based or sequence-specific oligonucleotide/primer molecular techniques.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    88381Consultation and review of cytogenetic or molecular test results (interpretation)May be billed when a pathologist or molecular specialist provides a separate, billable interpretation of complex HLA results.
    86152Antibody identification, solid phase (e.g., Luminex)Often performed alongside HLA typing for donor-specific antibody assessment in transplant evaluation.
    87220Culture, bacterial; presumptive identification by staining and microscopyNot directly related to HLA typing; Data not available in the input.
    0000FData not applicableData not available in the input.
    81299Unlisted molecular pathology procedureUsed when a specific molecular HLA test falls outside established codes and requires an unlisted code.

    Note: Related code selection is based on common laboratory and transplant workflows. If specific institutional billing pathways differ, local coding guidance should be consulted.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    207L00000X
    3336C0002X
    207K00000X
    374T00000X
    208C00000X
    261QM0850X
    261QC0050X

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    B20Human immunodeficiency virus [HIV] disease
    D47.2Monoclonal gammopathy
    D80.0Hereditary hypogammaglobulinemia
    D80.1Nonfamilial hypogammaglobulinemia
    D81.9Combined immunodeficiency, unspecified
    D84.9Immunodeficiency, unspecified
    L93.0Discoid lupus erythematosus
    M05.79Rheumatoid arthritis with rheumatoid factor of multiple sites without organ or systems involvement
    M06.9Rheumatoid arthritis, unspecified
    M32.9Systemic lupus erythematosus, unspecified

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Carrier Testing Panels for Genetic Diseases (for Kentucky Only)UnitedHealthcare2026-10-01
    Genetic Testing for Neurological Disorders (for Kansas Only)UnitedHealthcare2026-10-01
    Genetic and Molecular TestingProvidence Health Plan2026-10-01
    Cell-Free Fetal DNA Testing (for Idaho Only)UnitedHealthcare2026-10-01
    Next Generation Sequencing for Minimal Residual Disease DetectionProvidence Health Plan2026-10-01
    Pharmacogenetic Panel Testing (for Kansas Only)UnitedHealthcare2026-10-01
    Non-Covered Genetic Panel TestsProvidence Health Plan2026-10-01

    Related Codes

    CPT-81371-HLA-A-B-DRB1-LOW-INTERMEDIATE-RESOLUTION-TYPING

    CPT 81371: Low/Intermediate-Resolution HLA-A, -B, and -DRB1 Typing

    CPT-81372-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION-TYPING

    CPT 81372: HLA Class I Low/Intermediate Resolution Typing

    CPT-81373-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION

    CPT 81373: HLA Typing, Low or Intermediate Resolution, One Class I Locus

    CPT-81374-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION

    CPT 81374: HLA Class I Allele Group Typing, Low/Intermediate Resolution

    CPT-81375-HLA-CLASS-II-LOW-INTERMEDIATE-RESOLUTION-TYPING

    CPT 81375: HLA Class II Low/Intermediate-Resolution Molecular Typing

    CPT-81376-HLA-CLASS-II-TYPING-LOW-INTERMEDIATE-RESOLUTION-TECHNICAL

    CPT 81376: HLA Class II Low/Intermediate Resolution, Technical Test

    CPT-81377-HLA-CLASS-II-ALLELE-GROUP-TYPING-LOW-INTERMEDIATE-RESOLUTION

    CPT 81377: HLA Class II Allele Group Typing, Low/Intermediate Resolution

    CPT-81378-HLA-HIGH-RESOLUTION-MOLECULAR-TYPING-CLASS-I-II-DRB1

    CPT 81378: High-Resolution HLA Class I and II Typing

    CPT-81379-HLA-CLASS-I-HIGH-RESOLUTION-TYPING

    CPT 81379: HLA Class I High-Resolution Molecular Typing

    CPT-81380-HLA-HIGH-RESOLUTION-CLASS-I-TYPING

    CPT 81380: HLA High-Resolution Molecular Typing, One Class I Locus

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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