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    v1.0.30
    OpenPayerBilling CodesHLA TypingCPT cpt-81371-hla-a-b-drb1-low-intermediate-resolution-typing
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    CPT 81371: Low/Intermediate-Resolution HLA-A, -B, and -DRB1 Typing

    CPT code 81371 describes a laboratory molecular test for low- or intermediate-resolution typing of human leukocyte antigen (HLA) genes, reporting Class I loci HLA-A and HLA-B plus Class II locus HLA-DRB1; the service is a molecular genetics HLA typing procedure performed by a clinical laboratory and typically delivered in a clinical laboratory or reference lab setting for purposes such as donor-recipient matching and immunogenetic evaluation.

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.

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    Clinical & Coding Specifications

    Clinical Context

    A 35-year-old adult with end-stage renal disease is undergoing evaluation for kidney transplantation. The transplant center orders HLA typing to assess donor–recipient compatibility. A peripheral blood sample is collected in the outpatient phlebotomy clinic and sent to the molecular diagnostics laboratory. The laboratory technologist performs 81371 to determine low- or intermediate-resolution HLA typing for Class I loci HLA-A and HLA-B and Class II locus HLA-DRB1. Results are reported to the transplant team and entered into the organ allocation record to guide donor selection, crossmatch interpretation, and immunologic risk assessment. Typical sites of service include outpatient phlebotomy clinics, hospital laboratory services, reference molecular diagnostic laboratories, and transplant center labs. The patient encounter typically involves pre-transplant evaluation, donor workup, or compatibility assessment for living or deceased donor organ transplantation.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    88305Surgical pathology, gross and microscopic examinationMay be performed on donor tissue biopsies in transplant evaluation alongside HLA typing for histologic assessment.
    86830Crossmatch; major and minor (laboratory procedure)Performed to detect recipient antibodies reactive to donor cells; often used after HLA typing to confirm compatibility.
    81479Unlisted molecular pathology procedureUsed for reporting molecular tests not otherwise specified when additional or specialized HLA assays are required beyond 81371.
    88262HLA typing by serologic methods (if still used)Older methodology for HLA antigen typing; may be performed historically or in parallel in some centers.
    81375HLA typing, extended or high resolution (molecular)Performed when higher-resolution HLA typing is needed for donor–recipient matching or in stem cell transplantation contexts.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RG0300X
    207P00000X
    207L00000X
    363L00000X
    246ZE0600X
    2251N0400X
    2083B0002X
    261QR0207X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    B20Human immunodeficiency virus [HIV] disease
    D47.Z9Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue
    D56.9Thalassemia, unspecified
    D61.09Other constitutional aplastic anemia
    D68.9Coagulation defect, unspecified
    D84.9Immunodeficiency, unspecified
    D89.89Other specified disorders involving the immune mechanism, not elsewhere classified
    L93.0Discoid lupus erythematosus
    M32.9Systemic lupus erythematosus, unspecified
    T86.10Unspecified complication of kidney transplant

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Carrier Testing Panels for Genetic Diseases (for Kentucky Only)UnitedHealthcare2026-10-01
    Genetic Testing for Neurological Disorders (for Kansas Only)UnitedHealthcare2026-10-01
    Genetic and Molecular TestingProvidence Health Plan2026-10-01
    Cell-Free Fetal DNA Testing (for Idaho Only)UnitedHealthcare2026-10-01
    Next Generation Sequencing for Minimal Residual Disease DetectionProvidence Health Plan2026-10-01
    Pharmacogenetic Panel Testing (for Kansas Only)UnitedHealthcare2026-10-01
    Non-Covered Genetic Panel TestsProvidence Health Plan2026-10-01

    Related Codes

    CPT-81370-HLA-CLASS-I-II-LOW-INTERMEDIATE-RESOLUTION-TESTING

    CPT 81370: HLA Class I and II Low/Intermediate Resolution Typing

    CPT-81372-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION-TYPING

    CPT 81372: HLA Class I Low/Intermediate Resolution Typing

    CPT-81373-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION

    CPT 81373: HLA Typing, Low or Intermediate Resolution, One Class I Locus

    CPT-81374-HLA-CLASS-I-LOW-INTERMEDIATE-RESOLUTION

    CPT 81374: HLA Class I Allele Group Typing, Low/Intermediate Resolution

    CPT-81375-HLA-CLASS-II-LOW-INTERMEDIATE-RESOLUTION-TYPING

    CPT 81375: HLA Class II Low/Intermediate-Resolution Molecular Typing

    CPT-81376-HLA-CLASS-II-TYPING-LOW-INTERMEDIATE-RESOLUTION-TECHNICAL

    CPT 81376: HLA Class II Low/Intermediate Resolution, Technical Test

    CPT-81377-HLA-CLASS-II-ALLELE-GROUP-TYPING-LOW-INTERMEDIATE-RESOLUTION

    CPT 81377: HLA Class II Allele Group Typing, Low/Intermediate Resolution

    CPT-81378-HLA-HIGH-RESOLUTION-MOLECULAR-TYPING-CLASS-I-II-DRB1

    CPT 81378: High-Resolution HLA Class I and II Typing

    CPT-81379-HLA-CLASS-I-HIGH-RESOLUTION-TYPING

    CPT 81379: HLA Class I High-Resolution Molecular Typing

    CPT-81380-HLA-HIGH-RESOLUTION-CLASS-I-TYPING

    CPT 81380: HLA High-Resolution Molecular Typing, One Class I Locus

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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