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CPT 80439: Two-Hour TRH Stimulation Test for TSH Measurement
CPT code 80439 represents the two-hour thyrotropin releasing hormone (TRH) stimulation test, a dynamic endocrine diagnostic procedure in which TSH is measured in four serial blood samples—one pre-TRH and three post-TRH—to evaluate pituitary-thyroid axis function. Nationally, this specialized laboratory test is used in endocrine evaluation for conditions such as suspected central hypothyroidism, TSH-secreting pituitary adenomas, and complex thyroid function assessment where baseline measures are insufficient.
Key payers included in the analysis are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a clinical and billing-focused overview of the test, typical sites of service, common billing considerations, and how this service fits into endocrine diagnostic workflows. The publication summarizes benchmarks where available, highlights relevant coding and billing context, and outlines the clinical scenarios that commonly prompt use of the two-hour TRH stimulation test. Data not available in the input is noted where appropriate.
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Billing Code Overview
CPT code 80439 describes a laboratory procedure in which a lab analyst measures thyroid stimulating hormone (TSH) levels in four blood samples: one drawn before and three drawn after administration of thyrotropin releasing hormone (TRH). This code is used for the two-hour TRH stimulation test to assess thyroid function and pituitary-thyroid axis responsiveness.
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Service type: Dynamic endocrine diagnostic testing measuring serial TSH responses to TRH stimulation.
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Typical site of service: Hospital outpatient laboratory or clinical laboratory setting where controlled drug administration and timed blood draws are performed.