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CPT 80410: Calcitonin Stimulation Panel, Three Tests

CPT code 80410 represents a calcitonin stimulation panel involving three calcitonin measurements obtained after stimulation (for example with calcium or pentagastrin). This diagnostic laboratory test aids evaluation of calcitonin secretion and is clinically relevant in the assessment of suspected medullary thyroid carcinoma and other endocrine disorders. Nationally, the code matters because it captures a specialized endocrine assay that may affect diagnostic pathways and subsequent management decisions.

Key payers in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context and coding description, payer coverage considerations, common modifiers used with the service, and where available, benchmark and policy information relevant to laboratory coding for endocrine stimulation tests. The publication outlines typical sites of service and operational notes for labs and billing staff. Data not available in the input is identified where applicable.

This summary provides clinicians, laboratory managers, and coding professionals with the essential facts about CPT code 80410, what it denotes clinically, and the payer landscape to expect when documenting and billing a calcitonin stimulation panel.

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Billing Code Overview

CPT code 80410 describes a calcitonin stimulation panel in which a laboratory analyst performs stimulation testing (for example using calcium or pentagastrin) and measures three calcitonin levels. This service is a diagnostic laboratory procedure used to evaluate calcitonin secretion, commonly in the workup for suspected medullary thyroid carcinoma or related endocrine disorders.

Service type: Diagnostic endocrine laboratory testing (stimulation test)
Typical site of service: Clinical laboratory or hospital laboratory setting; testing is performed where stimulated blood sampling and timed assays can be collected and processed.

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CPT 80410: Calcitonin Stimulation Panel, Three Tests

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Billing Code Overview

Service type: Diagnostic endocrine laboratory testing (stimulation test)
Typical site of service: Clinical laboratory or hospital laboratory setting; testing is performed where stimulated blood sampling and timed assays can be collected and processed.

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult referred by an endocrinologist for a calcitonin stimulation panel to evaluate suspected medullary thyroid carcinoma (MTC) or to assess calcitonin secretion in the setting of a thyroid nodule or familial MEN2 syndrome. The patient presents to an outpatient phlebotomy or endocrine clinic. Baseline blood is drawn for a serum calcitonin level, then the laboratory-administered stimulation agent (commonly intravenous calcium or intramuscular pentagastrin where available) is given under monitored conditions. Serial blood samples are collected at specified intervals (commonly three post-stimulation draws) to measure stimulated calcitonin responses. Vital signs are monitored for adverse reactions to the stimulant; emergency equipment is available. The lab analyst performs three calcitonin assays from the timed specimens and reports baseline and stimulated values. Results are interpreted by the ordering clinician in the context of clinical findings, imaging, and family history to guide further diagnostic steps such as genetic testing or surgical referral. Typical sites of service are outpatient hospital laboratories, hospital outpatient departments, or freestanding clinical laboratories that can administer stimulation agents and perform timed phlebotomy and monitoring.

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when only the physician interpretation (professional component) of the lab result is billed separately from the technical component.
`TC`	Technical component	Use when only the technical component (laboratory processing and reporting) is billed.
`90`	Reference (outside) laboratory	Use when the test is performed by an outside laboratory and billed by the ordering laboratory.
`91`	Repeat clinical diagnostic laboratory test	Use when a repeat test is performed on the same day for verification of results due to analytic variability.
`52`	Reduced services	Use when the stimulation panel or number of draws is reduced (for example, fewer than the three expected post-stimulation samples) and documented.
`53`	Discontinued procedure	Use when the stimulation is started but discontinued for patient safety reasons (adverse reaction) and documented.
`59`	Distinct procedural service (note: not in provided list)	Data not available in the input.
`22`	Unusual procedural services (increased procedural services)	Use when extra time, technical effort, or complexity is required to complete the stimulation testing beyond typical circumstances.
`23`	Unusual anesthesia (waiver)	Use if testing required short-term use of general anesthesia (rare) — applied only when anesthesia services are documented.
`91`	Repeat clinical diagnostic laboratory test	Use when tests are repeated to confirm unexpected results (duplicate entry noted above intentionally avoided in practice).

Associated Provider Taxonomies

Taxonomy Code	Specialty	Notes
207RC0000X	Endocrinology, Diabetes & Metabolism	Ordering and interpreting clinicians for calcitonin stimulation tests.
2080P0002X	Clinical Pathology	Laboratory physicians overseeing test methodology and interpretation.
207LH0002X	Otolaryngology (ENT)	Surgeons who may receive results to plan thyroid surgery.
207K00000X	General Surgery	Surgeons involved in thyroidectomy for confirmed MTC.
261QM0800X	Clinical Laboratory Director	Directors responsible for laboratory testing protocols and quality control.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`E07.1`	Medullary carcinoma of thyroid	Primary indication for calcitonin stimulation testing to detect or monitor MTC.
`E04.1`	Nontoxic single thyroid nodule	Calcitonin stimulation used when a nodule raises concern for MTC, particularly if ultrasound features are suspicious.
`E34.0`	Endocrine neoplasms, unspecified	Used when endocrine tumor etiology is under evaluation and calcitonin aids in differential diagnosis.
`Z83.51`	Family history of endocrine neoplasm	Indicates familial risk (MEN2) where stimulated calcitonin testing may be performed for surveillance.
`R94.5`	Abnormal results of studies of thyroid function	Trigger for additional testing including stimulated calcitonin when initial labs or imaging are abnormal.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80410`	Calcitonin stimulation panel; performed with calcium or pentagastrin, includes three calcitonin tests	Primary code describing the lab analyst performing the stimulated calcitonin panel with three post-stimulation assays.
`84439`	Assay of calcitonin; immunoassay, quantitative	Common individual laboratory assay code used for each calcitonin measurement; may be billed by reference labs contributing technical component.
`96372`	Therapeutic, prophylactic, or diagnostic injection (e.g., subcutaneous or intramuscular)	May apply when pentagastrin (if available) is administered intramuscularly as the stimulation agent in an office or clinic setting.
`84460`	Thyroid stimulating hormone (TSH)	Often ordered concurrently in thyroid nodule workups to evaluate thyroid function alongside calcitonin testing.
`84443`	Thyroxine (T4), free	Frequently obtained in thyroid evaluation panels accompanying calcitonin stimulation testing.

Note: If an individual laboratory reports component billing, 26 and TC modifiers may be applied to separate professional and technical components as described above.

CPT 80400: ACTH Stimulation Test for Adrenal Function

CPT-80402-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

CPT 80402: ACTH Stimulation Test for Adrenal Function

CPT-80406-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

CPT 80406: ACTH Stimulation Test for Adrenal Function

CPT-80408-ALDOSTERONE-SUPPRESSION-EVALUATION-PANEL-SALINE-INFUSION

CPT 80408: Aldosterone Suppression Evaluation Panel

CPT-80412-CRH-STIMULATION-PANEL-CORTISOL-ACTH-ASSAYS

CPT 80412: CRH Stimulation Panel with Cortisol and ACTH Assays

CPT-80414-CHORIONIC-GONADOTROPIN-STIMULATION-TEST-TESTOSTERONE-PANEL

CPT 80414: Chorionic Gonadotropin Stimulation Test, Testosterone Panel

CPT-80415-CHORIONIC-GONADOTROPIN-ESTRADIOL-STIMULATION-PANEL

CPT 80415: Chorionic Gonadotropin Estradiol Stimulation Panel

CPT-80416-RENAL-VEIN-RENIN-MEASUREMENT

CPT 80416: Renal Vein Renin Measurement, Six-Sample Protocol

CPT-80417-STIMULATED-RENIN-MEASUREMENT

CPT 80417: Stimulated Renin Measurement

CPT-80418-ANTERIOR-PITUITARY-EVALUATION-PANEL-RAPID

CPT 80418: Rapid Combined Anterior Pituitary Evaluation Panel

Showing 1–10 of 22

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when only the physician interpretation (professional component) of the lab result is billed separately from the technical component.
`TC`	Technical component	Use when only the technical component (laboratory processing and reporting) is billed.
`90`	Reference (outside) laboratory	Use when the test is performed by an outside laboratory and billed by the ordering laboratory.
`91`	Repeat clinical diagnostic laboratory test	Use when a repeat test is performed on the same day for verification of results due to analytic variability.
`52`	Reduced services	Use when the stimulation panel or number of draws is reduced (for example, fewer than the three expected post-stimulation samples) and documented.
`53`	Discontinued procedure	Use when the stimulation is started but discontinued for patient safety reasons (adverse reaction) and documented.
`59`	Distinct procedural service (note: not in provided list)	Data not available in the input.
`22`	Unusual procedural services (increased procedural services)	Use when extra time, technical effort, or complexity is required to complete the stimulation testing beyond typical circumstances.
`23`	Unusual anesthesia (waiver)	Use if testing required short-term use of general anesthesia (rare) — applied only when anesthesia services are documented.
`91`	Repeat clinical diagnostic laboratory test	Use when tests are repeated to confirm unexpected results (duplicate entry noted above intentionally avoided in practice).

Associated Provider Taxonomies

Taxonomy Code	Specialty	Notes
207RC0000X	Endocrinology, Diabetes & Metabolism	Ordering and interpreting clinicians for calcitonin stimulation tests.
2080P0002X	Clinical Pathology	Laboratory physicians overseeing test methodology and interpretation.
207LH0002X	Otolaryngology (ENT)	Surgeons who may receive results to plan thyroid surgery.
207K00000X	General Surgery	Surgeons involved in thyroidectomy for confirmed MTC.
261QM0800X	Clinical Laboratory Director	Directors responsible for laboratory testing protocols and quality control.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`E07.1`	Medullary carcinoma of thyroid	Primary indication for calcitonin stimulation testing to detect or monitor MTC.
`E04.1`	Nontoxic single thyroid nodule	Calcitonin stimulation used when a nodule raises concern for MTC, particularly if ultrasound features are suspicious.
`E34.0`	Endocrine neoplasms, unspecified	Used when endocrine tumor etiology is under evaluation and calcitonin aids in differential diagnosis.
`Z83.51`	Family history of endocrine neoplasm	Indicates familial risk (MEN2) where stimulated calcitonin testing may be performed for surveillance.
`R94.5`	Abnormal results of studies of thyroid function	Trigger for additional testing including stimulated calcitonin when initial labs or imaging are abnormal.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80410`	Calcitonin stimulation panel; performed with calcium or pentagastrin, includes three calcitonin tests	Primary code describing the lab analyst performing the stimulated calcitonin panel with three post-stimulation assays.
`84439`	Assay of calcitonin; immunoassay, quantitative	Common individual laboratory assay code used for each calcitonin measurement; may be billed by reference labs contributing technical component.
`96372`	Therapeutic, prophylactic, or diagnostic injection (e.g., subcutaneous or intramuscular)	May apply when pentagastrin (if available) is administered intramuscularly as the stimulation agent in an office or clinic setting.
`84460`	Thyroid stimulating hormone (TSH)	Often ordered concurrently in thyroid nodule workups to evaluate thyroid function alongside calcitonin testing.
`84443`	Thyroxine (T4), free	Frequently obtained in thyroid evaluation panels accompanying calcitonin stimulation testing.

Note: If an individual laboratory reports component billing, 26 and TC modifiers may be applied to separate professional and technical components as described above.

CPT 80400: ACTH Stimulation Test for Adrenal Function

CPT-80402-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

CPT 80402: ACTH Stimulation Test for Adrenal Function

CPT-80406-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

CPT 80406: ACTH Stimulation Test for Adrenal Function

CPT-80408-ALDOSTERONE-SUPPRESSION-EVALUATION-PANEL-SALINE-INFUSION

CPT 80408: Aldosterone Suppression Evaluation Panel

CPT-80412-CRH-STIMULATION-PANEL-CORTISOL-ACTH-ASSAYS

CPT 80412: CRH Stimulation Panel with Cortisol and ACTH Assays

CPT-80414-CHORIONIC-GONADOTROPIN-STIMULATION-TEST-TESTOSTERONE-PANEL

CPT 80414: Chorionic Gonadotropin Stimulation Test, Testosterone Panel

CPT-80415-CHORIONIC-GONADOTROPIN-ESTRADIOL-STIMULATION-PANEL

CPT 80415: Chorionic Gonadotropin Estradiol Stimulation Panel

CPT-80416-RENAL-VEIN-RENIN-MEASUREMENT

CPT 80416: Renal Vein Renin Measurement, Six-Sample Protocol

CPT-80417-STIMULATED-RENIN-MEASUREMENT

CPT 80417: Stimulated Renin Measurement

CPT-80418-ANTERIOR-PITUITARY-EVALUATION-PANEL-RAPID

CPT 80418: Rapid Combined Anterior Pituitary Evaluation Panel

Showing 1–10 of 22

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

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CPT 80410: Calcitonin Stimulation Panel, Three Tests

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Billing Code Overview

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Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

CPT 80410: Calcitonin Stimulation Panel, Three Tests

Sign up for cpt 80410 policy alerts

Billing Code Overview

CPT 80410: Calcitonin Stimulation Panel, Three Tests

Sign up for cpt 80410 policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What clinical service does CPT 80410 represent and when is it typically used?

Which CPT modifiers are commonly used with 80410 and when should they be applied?

Where is the calcitonin stimulation panel (80410) usually performed and what operational requirements are indicated?

What related CPT codes or concurrent tests are commonly associated with 80410?

Which diagnosis codes are commonly linked to use of the calcitonin stimulation panel (80410)?

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

What clinical service does CPT 80410 represent and when is it typically used?

Which CPT modifiers are commonly used with 80410 and when should they be applied?

Where is the calcitonin stimulation panel (80410) usually performed and what operational requirements are indicated?

What related CPT codes or concurrent tests are commonly associated with 80410?

Which diagnosis codes are commonly linked to use of the calcitonin stimulation panel (80410)?

References