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    v1.0.30
    OpenPayerBilling CodesEvocative/Suppression Testing ProceduresCPT cpt-80410-calcitonin-stimulation-panel-three-tests
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    CPT 80410: Calcitonin Stimulation Panel, Three Measurements

    CPT code 80410 describes a laboratory calcitonin stimulation panel—for example using calcium or pentagastrin—that includes three separate calcitonin measurements; this is a specialized endocrine diagnostic blood test typically performed by a clinical laboratory or hospital laboratory as an outpatient or inpatient diagnostic service to evaluate suspected medullary thyroid carcinoma or other disorders of calcitonin secretion.

    For related coverage guidance, see recent payer policy updates: Diabetic Supplies, Radiofrequency Ablation for Thyroid Nodules, Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only).

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult referred by an endocrinologist for a calcitonin stimulation panel to evaluate suspected medullary thyroid carcinoma (MTC) or to assess calcitonin secretion in the setting of a thyroid nodule or familial MEN2 syndrome. The patient presents to an outpatient phlebotomy or endocrine clinic. Baseline blood is drawn for a serum calcitonin level, then the laboratory-administered stimulation agent (commonly intravenous calcium or intramuscular pentagastrin where available) is given under monitored conditions. Serial blood samples are collected at specified intervals (commonly three post-stimulation draws) to measure stimulated calcitonin responses. Vital signs are monitored for adverse reactions to the stimulant; emergency equipment is available. The lab analyst performs three calcitonin assays from the timed specimens and reports baseline and stimulated values. Results are interpreted by the ordering clinician in the context of clinical findings, imaging, and family history to guide further diagnostic steps such as genetic testing or surgical referral. Typical sites of service are outpatient hospital laboratories, hospital outpatient departments, or freestanding clinical laboratories that can administer stimulation agents and perform timed phlebotomy and monitoring.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80410Calcitonin stimulation panel; performed with calcium or pentagastrin, includes three calcitonin testsPrimary code describing the lab analyst performing the stimulated calcitonin panel with three post-stimulation assays.
    84439Assay of calcitonin; immunoassay, quantitativeCommon individual laboratory assay code used for each calcitonin measurement; may be billed by reference labs contributing technical component.
    96372Therapeutic, prophylactic, or diagnostic injection (e.g., subcutaneous or intramuscular)May apply when pentagastrin (if available) is administered intramuscularly as the stimulation agent in an office or clinic setting.
    84460Thyroid stimulating hormone (TSH)Often ordered concurrently in thyroid nodule workups to evaluate thyroid function alongside calcitonin testing.
    84443Thyroxine (T4), freeFrequently obtained in thyroid evaluation panels accompanying calcitonin stimulation testing.

    Note: If an individual laboratory reports component billing, 26 and TC modifiers may be applied to separate professional and technical components as described above.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    207LH0002X
    207K00000X
    225CA2500X
    175L00000X
    207ZC0500X
    3336M0002X
    364SP0812X

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Diabetic SuppliesCigna2026-10-15
    Radiofrequency Ablation for Thyroid NodulesCigna2026-10-15
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only)UnitedHealthcare2026-10-01
    Tzield (teplizumab-mzwv) CoverageUnitedHealthcare2026-10-01
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Indiana Only)UnitedHealthcare2026-10-01
    Medical Necessity Guidelines Insulin PumpsMass General Brigham Health Plan2026-10-01
    Medical Necessity Guidelines: Continuous Glucose MonitorsMass General Brigham Health Plan2026-10-01
    Continuous Glucose MonitoringAmbetter Nevada2026-10-01
    Salivary Hormone TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01

    Related Codes

    CPT-80400-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80400: ACTH Stimulation Test for Adrenal Function

    CPT-80402-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80402: ACTH Stimulation Test for Adrenal Function

    CPT-80406-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80406: ACTH Stimulation Test for Adrenal Function

    CPT-80408-ALDOSTERONE-SUPPRESSION-EVALUATION-PANEL-SALINE-INFUSION

    CPT 80408: Aldosterone Suppression Evaluation Panel

    CPT-80412-CRH-STIMULATION-PANEL-CORTISOL-ACTH-ASSAYS

    CPT 80412: CRH Stimulation Panel with Cortisol and ACTH Assays

    CPT-80414-CHORIONIC-GONADOTROPIN-STIMULATION-TEST-TESTOSTERONE-PANEL

    CPT 80414: Chorionic Gonadotropin Stimulation Panel for Testosterone Response

    CPT-80415-CHORIONIC-GONADOTROPIN-ESTRADIOL-STIMULATION-PANEL

    CPT 80415: Chorionic Gonadotropin Stimulation Estradiol Panel

    CPT-80416-RENAL-VEIN-RENIN-MEASUREMENT

    CPT 80416: Renal Vein Renin Measurement Pre- and Post-Stimulant

    CPT-80417-STIMULATED-RENIN-MEASUREMENT

    CPT 80417: Renin Measurement Before and After Captopril Stimulation

    CPT-80418-ANTERIOR-PITUITARY-EVALUATION-PANEL-RAPID

    CPT 80418: Rapid Anterior Pituitary Evaluation Panel

    Showing 1–10 of 22

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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