Summary & Overview
CPT 80415: Chorionic Gonadotropin Estradiol Stimulation Panel
CPT code 80415 denotes a chorionic gonadotropin stimulation panel performed in a laboratory to measure estradiol response using two estradiol assays (82670) on three pooled blood samples. This specialized endocrine test evaluates ovarian steroidogenic response to chorionic gonadotropin and is used in fertility and reproductive endocrinology contexts. Nationally, accurate coding ensures appropriate laboratory processing, reporting, and payer adjudication for complex hormone dynamic testing.
Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise clinical and billing overview of the panel, documentation elements tied to test composition, common payer considerations, and descriptions of typical sites of service (clinical or hospital laboratories). The publication outlines benchmarks for service definitions and coding clarity rather than specific reimbursement figures.
The content clarifies the technical requirements embedded in the code description — notably the requirement for two 82670 estradiol assays across three pooled samples — and summarizes implications for laboratory workflows and claims submission. Data not available in the input for associated taxonomies, ICD-10 diagnoses, and related codes.
Billing Code Overview
CPT code 80415 describes a chorionic gonadotropin stimulation panel performed by a laboratory analyst to assess estradiol response. The service requires measurement of estradiol levels and specifies two estradiol assays (82670) run on three pooled blood samples as part of the panel.
Service type: Laboratory diagnostic test — hormonal stimulation panel
Typical site of service: Clinical laboratory or hospital laboratory
Data not available in the input for associated taxonomies, ICD-10 diagnoses, and related codes.
Clinical & Coding Specifications
Clinical Context
A 32-year-old woman with secondary amenorrhea and infertility assessment is referred to a reproductive endocrinology laboratory for endocrine stimulation testing. The clinician orders a chorionic gonadotropin (hCG) stimulation panel to evaluate ovarian responsiveness by measuring estradiol production after hCG challenge. The laboratory obtains three pooled blood samples at the time points specified by the ordering provider (commonly baseline and two post-stimulation draws), performs two estradiol assays (82670) on each pooled sample as required by the panel definition, and reports the estradiol response curve. Typical workflow includes patient arrival and identification, baseline specimen collection, administration of hCG per protocol, timed post-hCG specimen collections, specimen pooling and labeling, running duplicate estradiol assays, verification by the lab analyst, and result reporting to the ordering reproductive endocrinologist.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
26 | Professional component | Use when only the physician interpretation/professional component of the test is billed separately from the technical component. |
TC |