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    v1.0.30
    OpenPayerBilling CodesEvocative/Suppression Testing ProceduresCPT cpt-80415-chorionic-gonadotropin-estradiol-stimulation-panel
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    CPT 80415: Chorionic Gonadotropin Stimulation Estradiol Panel

    CPT code 80415 describes a chorionic gonadotropin stimulation panel in which the laboratory analyst measures the estradiol response by performing two estradiol assays (82670) on three pooled blood samples; this is a specialized endocrine stimulation test typically performed as a laboratory service in a clinical laboratory or hospital laboratory setting to assess ovarian steroid responsiveness after hCG challenge.

    For related coverage guidance, see recent payer policy updates: Diabetic Supplies, Radiofrequency Ablation for Thyroid Nodules, Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only).

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    Clinical & Coding Specifications

    Clinical Context

    A 32-year-old woman with secondary amenorrhea and infertility assessment is referred to a reproductive endocrinology laboratory for endocrine stimulation testing. The clinician orders a chorionic gonadotropin (hCG) stimulation panel to evaluate ovarian responsiveness by measuring estradiol production after hCG challenge. The laboratory obtains three pooled blood samples at the time points specified by the ordering provider (commonly baseline and two post-stimulation draws), performs two estradiol assays (82670) on each pooled sample as required by the panel definition, and reports the estradiol response curve. Typical workflow includes patient arrival and identification, baseline specimen collection, administration of hCG per protocol, timed post-hCG specimen collections, specimen pooling and labeling, running duplicate estradiol assays, verification by the lab analyst, and result reporting to the ordering reproductive endocrinologist.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    82670Estradiol; quantitative, by assayThis code is the component assay required by the panel; the panel definition mandates two 82670 assays on three pooled samples.
    80053Comprehensive metabolic panelOften ordered concurrently to assess baseline metabolic status prior to stimulation testing.
    83986Thyroid stimulating hormone (TSH) assayCommon adjunct test in infertility evaluation to assess thyroid function impacting ovarian response.
    84702Luteinizing hormone (LH) assayOften measured alongside estradiol to interpret ovarian response dynamics.
    84443Thyroxine (T4), free or totalFrequently included in the endocrine workup for infertility and amenorrhea.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207L00000X
    320600000X
    2471C3402X
    163WX1100X
    2472B0301X
    171W00000X
    173000000X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    E23.0Hypopituitarism
    E28.1Androgen excess
    E28.2Polycystic ovarian syndrome
    E28.39Other primary ovarian failure
    E28.9Ovarian dysfunction, unspecified
    E34.9Endocrine disorder, unspecified
    N91.0Primary amenorrhea
    N91.1Secondary amenorrhea
    N91.2Amenorrhea, unspecified
    N92.0Excessive and frequent menstruation with regular cycle

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Diabetic SuppliesCigna2026-10-15
    Radiofrequency Ablation for Thyroid NodulesCigna2026-10-15
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only)UnitedHealthcare2026-10-01
    Tzield (teplizumab-mzwv) CoverageUnitedHealthcare2026-10-01
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Indiana Only)UnitedHealthcare2026-10-01
    Medical Necessity Guidelines Insulin PumpsMass General Brigham Health Plan2026-10-01
    Medical Necessity Guidelines: Continuous Glucose MonitorsMass General Brigham Health Plan2026-10-01
    Continuous Glucose MonitoringAmbetter Nevada2026-10-01
    Salivary Hormone TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01

    Related Codes

    CPT-80400-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80400: ACTH Stimulation Test for Adrenal Function

    CPT-80402-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80402: ACTH Stimulation Test for Adrenal Function

    CPT-80406-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80406: ACTH Stimulation Test for Adrenal Function

    CPT-80408-ALDOSTERONE-SUPPRESSION-EVALUATION-PANEL-SALINE-INFUSION

    CPT 80408: Aldosterone Suppression Evaluation Panel

    CPT-80410-CALCITONIN-STIMULATION-PANEL-THREE-TESTS

    CPT 80410: Calcitonin Stimulation Panel, Three Measurements

    CPT-80412-CRH-STIMULATION-PANEL-CORTISOL-ACTH-ASSAYS

    CPT 80412: CRH Stimulation Panel with Cortisol and ACTH Assays

    CPT-80414-CHORIONIC-GONADOTROPIN-STIMULATION-TEST-TESTOSTERONE-PANEL

    CPT 80414: Chorionic Gonadotropin Stimulation Panel for Testosterone Response

    CPT-80416-RENAL-VEIN-RENIN-MEASUREMENT

    CPT 80416: Renal Vein Renin Measurement Pre- and Post-Stimulant

    CPT-80417-STIMULATED-RENIN-MEASUREMENT

    CPT 80417: Renin Measurement Before and After Captopril Stimulation

    CPT-80418-ANTERIOR-PITUITARY-EVALUATION-PANEL-RAPID

    CPT 80418: Rapid Anterior Pituitary Evaluation Panel

    Showing 1–10 of 22

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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