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    v1.0.30
    OpenPayerBilling CodesEvocative/Suppression Testing ProceduresCPT cpt-80406-acth-stimulation-test-adrenal-function
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    CPT 80406: ACTH Stimulation Test for Adrenal Function

    CPT code 80406 describes an ACTH stimulation test, a diagnostic endocrine procedure that measures serum cortisol response after administration of synthetic adrenocorticotropic hormone to assess adrenal gland function; the service is a diagnostic endocrine laboratory test typically performed in an outpatient clinic, endocrinology office, or hospital outpatient laboratory with specimen collection and timed cortisol measurements.

    For related coverage guidance, see recent payer policy updates: Diabetic Supplies, Radiofrequency Ablation for Thyroid Nodules, Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 46-year-old female presents to an endocrine clinic with progressive fatigue, unintentional weight loss, orthostatic dizziness, and hyperpigmentation. The endocrinologist suspects primary adrenal insufficiency and orders an ACTH stimulation test to evaluate adrenal cortisol reserve. On the day of testing the patient arrives fasting; baseline serum cortisol and plasma ACTH are drawn. Synthetic cosyntropin is administered intravenously or intramuscularly, and cortisol levels are measured at baseline, 30, and 60 minutes. The endocrinologist interprets the cortisol response in the context of baseline ACTH, prior glucocorticoid use, and clinical signs to confirm primary versus secondary adrenal insufficiency and to guide treatment decisions.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80406ACTH stimulation test (cosyntropin stimulation) — administration and cortisol measurementPrimary code describing the procedure performed to assess adrenal cortisol response.
    36415Collection of venous blood by venipunctureVenipuncture is required to obtain baseline and timed cortisol specimens.
    82725Cortisol; totalLaboratory assay commonly performed on collected specimens as part of the stimulation test.
    Q9905Clinical diagnostic laboratory test, not otherwise classified (used for certain specialized assays)May be used for specialized cortisol or ACTH assay billing when applicable.
    99213Office or other outpatient visit for the evaluation and management of an established patientTypical outpatient visit code used for pre-test evaluation and post-test interpretation by the ordering clinician.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RE0101X
    207RC0000X
    208D00000X
    363L00000X
    363LS0200X
    175L00000X
    374T00000X
    207ZP0101X

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    E03.9Hypothyroidism, unspecified
    E10.65Type 1 diabetes mellitus with hyperglycemia
    E11.65Type 2 diabetes mellitus with hyperglycemia
    E16.0Drug-induced hypoglycemia without coma
    E16.2Hypoglycemia, unspecified
    E24.0Pituitary-dependent Cushing's disease
    E24.1Nelson's syndrome
    E24.2Drug-induced Cushing's syndrome
    E24.9Cushing's syndrome, unspecified
    E27.0Other adrenocortical overactivity

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Diabetic SuppliesCigna2026-10-15
    Radiofrequency Ablation for Thyroid NodulesCigna2026-10-15
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only)UnitedHealthcare2026-10-01
    Tzield (teplizumab-mzwv) CoverageUnitedHealthcare2026-10-01
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Indiana Only)UnitedHealthcare2026-10-01
    Medical Necessity Guidelines Insulin PumpsMass General Brigham Health Plan2026-10-01
    Medical Necessity Guidelines: Continuous Glucose MonitorsMass General Brigham Health Plan2026-10-01
    Continuous Glucose MonitoringAmbetter Nevada2026-10-01
    Salivary Hormone TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01

    Related Codes

    CPT-80400-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80400: ACTH Stimulation Test for Adrenal Function

    CPT-80402-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80402: ACTH Stimulation Test for Adrenal Function

    CPT-80408-ALDOSTERONE-SUPPRESSION-EVALUATION-PANEL-SALINE-INFUSION

    CPT 80408: Aldosterone Suppression Evaluation Panel

    CPT-80410-CALCITONIN-STIMULATION-PANEL-THREE-TESTS

    CPT 80410: Calcitonin Stimulation Panel, Three Measurements

    CPT-80412-CRH-STIMULATION-PANEL-CORTISOL-ACTH-ASSAYS

    CPT 80412: CRH Stimulation Panel with Cortisol and ACTH Assays

    CPT-80414-CHORIONIC-GONADOTROPIN-STIMULATION-TEST-TESTOSTERONE-PANEL

    CPT 80414: Chorionic Gonadotropin Stimulation Panel for Testosterone Response

    CPT-80415-CHORIONIC-GONADOTROPIN-ESTRADIOL-STIMULATION-PANEL

    CPT 80415: Chorionic Gonadotropin Stimulation Estradiol Panel

    CPT-80416-RENAL-VEIN-RENIN-MEASUREMENT

    CPT 80416: Renal Vein Renin Measurement Pre- and Post-Stimulant

    CPT-80417-STIMULATED-RENIN-MEASUREMENT

    CPT 80417: Renin Measurement Before and After Captopril Stimulation

    CPT-80418-ANTERIOR-PITUITARY-EVALUATION-PANEL-RAPID

    CPT 80418: Rapid Anterior Pituitary Evaluation Panel

    Showing 1–10 of 22

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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