CPT code 80406 designates the ACTH stimulation test, a diagnostic procedure used by endocrinologists to evaluate adrenal gland function by measuring cortisol levels in response to synthetic adrenocorticotropic hormone. Nationally, this test is an important tool for diagnosing adrenal insufficiency, secondary adrenal disorders, and for assessing the hypothalamic-pituitary-adrenal axis in complex endocrine cases.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find clinical context about when the ACTH stimulation test is used, typical sites of service such as hospital outpatient clinics, outpatient laboratories, and endocrinology clinics, and an overview of billing considerations relevant to payers. The publication summarizes standard use cases, common claim modifiers (input provided), and notes where input data is not available.

This resource is intended for billing managers, practice administrators, and clinicians who need a concise summary of the test’s clinical purpose and payer relevance. It highlights benchmark and policy topics typically addressed for procedural lab testing reimbursement and claims handling, while noting where specific payer policy details or diagnosis mapping were not provided in the input.