Headline: CPT code 80408: Aldosterone Suppression Evaluation Panel for Primary Aldosteronism Workup

Lead: CPT code 80408 identifies a laboratory diagnostic panel used to evaluate aldosterone suppression, commonly performed as a saline infusion test and requiring paired aldosterone and renin measurements. This panel supports definitive biochemical assessment in patients being evaluated for primary aldosteronism and informs subsequent clinical and procedural decisions.

CPT code 80408 matters nationally because it standardizes reporting for a specific endocrine diagnostic panel that requires multiple timed assays and often involves monitored infusion procedures in a clinical laboratory setting. Payors commonly referenced in coverage and payment discussions for this service include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare.

Readers will learn the clinical context and service setting associated with the code, the typical laboratory composition (two aldosterone and two renin assays), and which major payors are relevant to billing and coverage conversations. The publication also summarizes common billing modifiers and identifies where data is unavailable. Benchmarks, policy updates, and clinical guidance relevant to utilization and coding practices are presented to help billing professionals and clinical laboratories align claims submission with payer expectations.