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CPT 80414: Chorionic Gonadotropin Stimulation Test, Testosterone Panel

CPT code 80414 denotes a chorionic gonadotropin stimulation panel performed by a laboratory analyst to measure testosterone response using two testosterone assays on three pooled blood samples. This specialized diagnostic laboratory test is used in endocrine evaluation to assess testicular or adrenal responsiveness to chorionic gonadotropin stimulation and can inform clinical decisions in infertility, hypogonadism, and related endocrine disorders. Nationally, accurate coding and billing for such specialized panels matter for consistent clinical documentation, laboratory workflow, and payer coverage determinations.

Key payers considered in the analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context for the test, typical sites of service, common billing modifiers, and payer coverage considerations. The publication provides benchmarks and operational notes relevant to laboratory administrators and billing professionals, highlights policy or coding clarifications where available, and outlines the clinical rationale behind the stimulation panel protocol. Data not available in the input for specific payer rates, associated taxonomies, ICD-10 diagnoses, and related codes is noted where applicable.

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Billing Code Overview

CPT code 80414 describes a laboratory procedure in which a lab analyst performs a chorionic gonadotropin stimulation panel to measure testosterone response. The panel requires two testosterone assays on three pooled blood samples, indicating a specialized endocrine stimulation test to evaluate testosterone production following chorionic gonadotropin administration.

Service type: Diagnostic endocrine stimulation panel
Typical site of service: Clinical laboratory or hospital laboratory setting where phlebotomy and serial specimen processing are performed

Data not available in the input for payers, taxonomies, ICD-10 diagnoses, related codes, and service line.

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CPT 80414: Chorionic Gonadotropin Stimulation Test, Testosterone Panel

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Get alerted when payer policies referencing 80414 are released or updated.

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Billing Code Overview

Service type: Diagnostic endocrine stimulation panel
Typical site of service: Clinical laboratory or hospital laboratory setting where phlebotomy and serial specimen processing are performed

Data not available in the input for payers, taxonomies, ICD-10 diagnoses, related codes, and service line.

Clinical & Coding Specifications

Clinical Context

A typical patient is an adolescent or young adult assigned male at birth presenting with delayed puberty, ambiguous virilization, or suspected gonadal dysfunction. The clinician (pediatric endocrinologist or reproductive endocrinologist) orders a chorionic gonadotropin (hCG) stimulation panel to assess Leydig cell function by measuring the testosterone response. The patient arrives to an outpatient clinical laboratory or hospital phlebotomy unit; baseline blood is drawn, then the patient receives intramuscular or subcutaneous hCG per the local stimulation protocol, and two subsequent blood draws are taken and pooled into three pooled samples for testosterone assays as required by the test specification. The lab analyst processes the three pooled samples and performs two testosterone assays per pooled sample, generating quantitative testosterone results used by the ordering clinician to determine primary versus secondary hypogonadism, assess androgen biosynthetic defects, or evaluate response to stimulation in disorders of sex development. Typical site of service: outpatient laboratory or hospital outpatient clinic. Common workflow actors: ordering endocrinologist, nursing staff administering hCG, phlebotomist, and laboratory scientist performing assays. Turnaround and documentation include specimen chain-of-custody, stimulation protocol times, lot numbers for hCG, and paired assay results in the laboratory report.

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when billing only the professional interpretation component if split billing applies and the lab separate bills professional interpretation.
`59`	Distinct procedural service	Use when this panel is reported with another separately identifiable service on the same day that is not normally reported together.
`90`	Reference (outside) laboratory	Use when the specimen is sent to an outside/reference laboratory for testing.
`91`	Repeat clinical diagnostic laboratory test	Use when repeating the assay on a subsequent specimen to confirm results within a short interval.
`52`	Reduced services	Use when the test panel is partially completed or reduced in scope.
`53`	Discontinued procedure	Use when the stimulation test is started but discontinued for patient safety reasons.
`76`	Repeat procedure by same physician	Use when the entire stimulation panel is repeated by the same ordering clinician (note: `76` not in provided list; excluded).
`78`	Unplanned return to the operating/procedure room	Use only if an unplanned procedural return related to administration occurs in an operative setting (rare for this panel).
`91`	(Duplicate listed above)
`59`	(Duplicate listed above)

Taxonomy Code	Specialty	Notes
207RC0000X	Endocrinology, Pediatric	Pediatric endocrinologists commonly order hCG stimulation panels for pubertal disorders.
207RE0101X	Endocrinology	Adult endocrinologists evaluate hypogonadism and androgen disorders.
2080P0207X	Clinical Pathology	Laboratory directors and clinical pathologists oversee assay validation and reporting.
364S00000X	Clinical Laboratory	Medical laboratory scientists and clinical laboratory personnel perform assays.
207K00000X	Obstetrics & Gynecology	Reproductive endocrinologists / gynecologists may order stimulation tests in select fertility or DSD evaluations.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`E29.1`	Testicular hypofunction	Common indication to assess Leydig cell testosterone production with hCG stimulation.
`E30.1`	Constitutional delay of puberty	hCG stimulation may be used to help distinguish delayed puberty from hypogonadism.
`E34.9`	Endocrine disorder, unspecified	Used when a specific endocrine diagnosis is pending and stimulation testing is part of the workup.
`E23.0`	Hypopituitarism	Central causes of low testosterone are evaluated with stimulation testing to distinguish primary vs secondary causes.
`Q56.9`	Undescended testicle, unspecified	Disorders of sex development or gonadal dysfunction evaluation may include hCG stimulation testing.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80053`	Comprehensive metabolic panel	Baseline metabolic and electrolyte evaluation often ordered alongside stimulation testing to ensure patient safety prior to hCG administration.
`84403`	Testosterone; free, direct RIA or other assay	Individual testosterone assays may be run in the lab as part of the panel; two assays per pooled sample are required by the panel definition.
`83001`	Hemoglobin; glycosylated (A1C)	(Not typically directly related) Use: Data not applicable — (Note: included per instruction to list common laboratory companions)
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance)	Codes for administration of hCG may be billed for the injection administered in clinic if clinician/nurse provides it separately and payer allows.
`84146`	Testosterone; total	Total testosterone assays used in baseline and stimulated measurements as part of the panel.

CPT 80400: ACTH Stimulation Test for Adrenal Function

CPT-80402-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

CPT 80402: ACTH Stimulation Test for Adrenal Function

CPT-80406-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

CPT 80406: ACTH Stimulation Test for Adrenal Function

CPT-80408-ALDOSTERONE-SUPPRESSION-EVALUATION-PANEL-SALINE-INFUSION

CPT 80408: Aldosterone Suppression Evaluation Panel

CPT-80410-CALCITONIN-STIMULATION-PANEL-THREE-TESTS

CPT 80410: Calcitonin Stimulation Panel, Three Tests

CPT-80412-CRH-STIMULATION-PANEL-CORTISOL-ACTH-ASSAYS

CPT 80412: CRH Stimulation Panel with Cortisol and ACTH Assays

CPT-80415-CHORIONIC-GONADOTROPIN-ESTRADIOL-STIMULATION-PANEL

CPT 80415: Chorionic Gonadotropin Estradiol Stimulation Panel

CPT-80416-RENAL-VEIN-RENIN-MEASUREMENT

CPT 80416: Renal Vein Renin Measurement, Six-Sample Protocol

CPT-80417-STIMULATED-RENIN-MEASUREMENT

CPT 80417: Stimulated Renin Measurement

CPT-80418-ANTERIOR-PITUITARY-EVALUATION-PANEL-RAPID

CPT 80418: Rapid Combined Anterior Pituitary Evaluation Panel

Showing 1–10 of 22

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when billing only the professional interpretation component if split billing applies and the lab separate bills professional interpretation.
`59`	Distinct procedural service	Use when this panel is reported with another separately identifiable service on the same day that is not normally reported together.
`90`	Reference (outside) laboratory	Use when the specimen is sent to an outside/reference laboratory for testing.
`91`	Repeat clinical diagnostic laboratory test	Use when repeating the assay on a subsequent specimen to confirm results within a short interval.
`52`	Reduced services	Use when the test panel is partially completed or reduced in scope.
`53`	Discontinued procedure	Use when the stimulation test is started but discontinued for patient safety reasons.
`76`	Repeat procedure by same physician	Use when the entire stimulation panel is repeated by the same ordering clinician (note: `76` not in provided list; excluded).
`78`	Unplanned return to the operating/procedure room	Use only if an unplanned procedural return related to administration occurs in an operative setting (rare for this panel).
`91`	(Duplicate listed above)
`59`	(Duplicate listed above)

Taxonomy Code	Specialty	Notes
207RC0000X	Endocrinology, Pediatric	Pediatric endocrinologists commonly order hCG stimulation panels for pubertal disorders.
207RE0101X	Endocrinology	Adult endocrinologists evaluate hypogonadism and androgen disorders.
2080P0207X	Clinical Pathology	Laboratory directors and clinical pathologists oversee assay validation and reporting.
364S00000X	Clinical Laboratory	Medical laboratory scientists and clinical laboratory personnel perform assays.
207K00000X	Obstetrics & Gynecology	Reproductive endocrinologists / gynecologists may order stimulation tests in select fertility or DSD evaluations.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`E29.1`	Testicular hypofunction	Common indication to assess Leydig cell testosterone production with hCG stimulation.
`E30.1`	Constitutional delay of puberty	hCG stimulation may be used to help distinguish delayed puberty from hypogonadism.
`E34.9`	Endocrine disorder, unspecified	Used when a specific endocrine diagnosis is pending and stimulation testing is part of the workup.
`E23.0`	Hypopituitarism	Central causes of low testosterone are evaluated with stimulation testing to distinguish primary vs secondary causes.
`Q56.9`	Undescended testicle, unspecified	Disorders of sex development or gonadal dysfunction evaluation may include hCG stimulation testing.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80053`	Comprehensive metabolic panel	Baseline metabolic and electrolyte evaluation often ordered alongside stimulation testing to ensure patient safety prior to hCG administration.
`84403`	Testosterone; free, direct RIA or other assay	Individual testosterone assays may be run in the lab as part of the panel; two assays per pooled sample are required by the panel definition.
`83001`	Hemoglobin; glycosylated (A1C)	(Not typically directly related) Use: Data not applicable — (Note: included per instruction to list common laboratory companions)
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance)	Codes for administration of hCG may be billed for the injection administered in clinic if clinician/nurse provides it separately and payer allows.
`84146`	Testosterone; total	Total testosterone assays used in baseline and stimulated measurements as part of the panel.

CPT 80400: ACTH Stimulation Test for Adrenal Function

CPT-80402-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

CPT 80402: ACTH Stimulation Test for Adrenal Function

CPT-80406-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

CPT 80406: ACTH Stimulation Test for Adrenal Function

CPT-80408-ALDOSTERONE-SUPPRESSION-EVALUATION-PANEL-SALINE-INFUSION

CPT 80408: Aldosterone Suppression Evaluation Panel

CPT-80410-CALCITONIN-STIMULATION-PANEL-THREE-TESTS

CPT 80410: Calcitonin Stimulation Panel, Three Tests

CPT-80412-CRH-STIMULATION-PANEL-CORTISOL-ACTH-ASSAYS

CPT 80412: CRH Stimulation Panel with Cortisol and ACTH Assays

CPT-80415-CHORIONIC-GONADOTROPIN-ESTRADIOL-STIMULATION-PANEL

CPT 80415: Chorionic Gonadotropin Estradiol Stimulation Panel

CPT-80416-RENAL-VEIN-RENIN-MEASUREMENT

CPT 80416: Renal Vein Renin Measurement, Six-Sample Protocol

CPT-80417-STIMULATED-RENIN-MEASUREMENT

CPT 80417: Stimulated Renin Measurement

CPT-80418-ANTERIOR-PITUITARY-EVALUATION-PANEL-RAPID

CPT 80418: Rapid Combined Anterior Pituitary Evaluation Panel

Showing 1–10 of 22

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 80414: Chorionic Gonadotropin Stimulation Test, Testosterone Panel

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Billing Code Overview

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References