Summary & Overview
CPT 80414: Chorionic Gonadotropin Stimulation Test, Testosterone Panel
CPT code 80414 denotes a chorionic gonadotropin stimulation panel performed by a laboratory analyst to measure testosterone response using two testosterone assays on three pooled blood samples. This specialized diagnostic laboratory test is used in endocrine evaluation to assess testicular or adrenal responsiveness to chorionic gonadotropin stimulation and can inform clinical decisions in infertility, hypogonadism, and related endocrine disorders. Nationally, accurate coding and billing for such specialized panels matter for consistent clinical documentation, laboratory workflow, and payer coverage determinations.
Key payers considered in the analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context for the test, typical sites of service, common billing modifiers, and payer coverage considerations. The publication provides benchmarks and operational notes relevant to laboratory administrators and billing professionals, highlights policy or coding clarifications where available, and outlines the clinical rationale behind the stimulation panel protocol. Data not available in the input for specific payer rates, associated taxonomies, ICD-10 diagnoses, and related codes is noted where applicable.
Billing Code Overview
CPT code 80414 describes a laboratory procedure in which a lab analyst performs a chorionic gonadotropin stimulation panel to measure testosterone response. The panel requires two testosterone assays on three pooled blood samples, indicating a specialized endocrine stimulation test to evaluate testosterone production following chorionic gonadotropin administration.
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Service type: Diagnostic endocrine stimulation panel
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Typical site of service: Clinical laboratory or hospital laboratory setting where phlebotomy and serial specimen processing are performed
Data not available in the input for payers, taxonomies, ICD-10 diagnoses, related codes, and service line.
Clinical & Coding Specifications
Clinical Context
A typical patient is an adolescent or young adult assigned male at birth presenting with delayed puberty, ambiguous virilization, or suspected gonadal dysfunction. The clinician (pediatric endocrinologist or reproductive endocrinologist) orders a chorionic gonadotropin (hCG) stimulation panel to assess Leydig cell function by measuring the testosterone response. The patient arrives to an outpatient clinical laboratory or hospital phlebotomy unit; baseline blood is drawn, then the patient receives intramuscular or subcutaneous hCG per the local stimulation protocol, and two subsequent blood draws are taken and pooled into three pooled samples for testosterone assays as required by the test specification. The lab analyst processes the three pooled samples and performs two testosterone assays per pooled sample, generating quantitative testosterone results used by the ordering clinician to determine primary versus secondary hypogonadism, assess androgen biosynthetic defects, or evaluate response to stimulation in disorders of sex development. Typical site of service: outpatient laboratory or hospital outpatient clinic. Common workflow actors: ordering endocrinologist, nursing staff administering hCG, phlebotomist, and laboratory scientist performing assays. Turnaround and documentation include specimen chain-of-custody, stimulation protocol times, lot numbers for hCG, and paired assay results in the laboratory report.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
26 | Professional component | Use when billing only the professional interpretation component if split billing applies and the lab separate bills professional interpretation. |