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    v1.0.30
    OpenPayerBilling CodesEvocative/Suppression Testing ProceduresCPT cpt-80402-acth-stimulation-test-adrenal-function
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    CPT 80402: ACTH Stimulation Test for Adrenal Function

    CPT code 80402 represents an ACTH stimulation test used to evaluate adrenal gland function by measuring cortisol response after administration of synthetic adrenocorticotropic hormone; this is a laboratory diagnostic procedure typically ordered and interpreted by endocrinologists and performed in an ambulatory clinic or hospital outpatient laboratory setting.

    For related coverage guidance, see recent payer policy updates: Diabetic Supplies, Radiofrequency Ablation for Thyroid Nodules, Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 45-year-old woman with progressive fatigue, weight loss, orthostatic dizziness, and hyperpigmentation presents to an endocrinology clinic. The endocrinologist suspects primary or secondary adrenal insufficiency and orders an ACTH stimulation test to evaluate adrenal cortisol reserve. The patient arrives fasting to the outpatient infusion suite or endocrine clinic laboratory. Baseline vital signs and a baseline serum cortisol are obtained, followed by administration of synthetic adrenocorticotropic hormone (cosyntropin). Serum cortisol is drawn at specified intervals (commonly 30 and 60 minutes). Results are interpreted by the endocrinologist to determine whether cortisol response is adequate, informing diagnosis (primary vs secondary adrenal insufficiency), need for further testing (insulin tolerance test, morning cortisol/ACTH), and management (glucocorticoid replacement). Typical sites of service include outpatient clinic-based procedure rooms, hospital outpatient departments, and hospital inpatient floors when assessing acutely ill patients. The service is ordered and interpreted by an endocrinologist and may involve registered nurses or phlebotomists for medication administration and timed blood draws.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36415Collection of venous blood by venipunctureUsed for baseline and timed cortisol blood draws required for the ACTH stimulation test.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance)Used when cosyntropin (synthetic ACTH) is administered intramuscularly or intravenously in settings where injection billing is appropriate.
    80970Cortisol; serum or plasma, totalLaboratory assay usually performed on samples obtained during the test to measure cortisol concentrations.
    83520Aldosterone; direct measurementMay be ordered concurrently if assessing adrenal function and primary hyperaldosteronism is a concern.
    84436Thyroid stimulating hormone (TSH)Often part of a broader endocrine evaluation when considering causes for fatigue and suspected adrenal disease.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RE0101X
    207K00000X
    103K00000X
    163WA0400X
    364S00000X
    207LP4000X
    341800000X
    163WL0100X

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    E10.65Type 1 diabetes mellitus with hyperglycemia
    E11.65Type 2 diabetes mellitus with hyperglycemia
    E16.2Hypoglycemia, unspecified
    E22.0Acromegaly and pituitary gigantism
    E22.1Hyperprolactinemia
    E22.8Other hyperfunction of pituitary gland
    E22.9Hyperfunction of pituitary gland, unspecified
    E24.0Pituitary-dependent Cushing's disease
    E24.1Nelson's syndrome
    E24.8Other Cushing's syndrome

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Diabetic SuppliesCigna2026-10-15
    Radiofrequency Ablation for Thyroid NodulesCigna2026-10-15
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only)UnitedHealthcare2026-10-01
    Tzield (teplizumab-mzwv) CoverageUnitedHealthcare2026-10-01
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Indiana Only)UnitedHealthcare2026-10-01
    Medical Necessity Guidelines Insulin PumpsMass General Brigham Health Plan2026-10-01
    Medical Necessity Guidelines: Continuous Glucose MonitorsMass General Brigham Health Plan2026-10-01
    Continuous Glucose MonitoringAmbetter Nevada2026-10-01
    Salivary Hormone TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01

    Related Codes

    CPT-80400-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80400: ACTH Stimulation Test for Adrenal Function

    CPT-80406-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80406: ACTH Stimulation Test for Adrenal Function

    CPT-80408-ALDOSTERONE-SUPPRESSION-EVALUATION-PANEL-SALINE-INFUSION

    CPT 80408: Aldosterone Suppression Evaluation Panel

    CPT-80410-CALCITONIN-STIMULATION-PANEL-THREE-TESTS

    CPT 80410: Calcitonin Stimulation Panel, Three Measurements

    CPT-80412-CRH-STIMULATION-PANEL-CORTISOL-ACTH-ASSAYS

    CPT 80412: CRH Stimulation Panel with Cortisol and ACTH Assays

    CPT-80414-CHORIONIC-GONADOTROPIN-STIMULATION-TEST-TESTOSTERONE-PANEL

    CPT 80414: Chorionic Gonadotropin Stimulation Panel for Testosterone Response

    CPT-80415-CHORIONIC-GONADOTROPIN-ESTRADIOL-STIMULATION-PANEL

    CPT 80415: Chorionic Gonadotropin Stimulation Estradiol Panel

    CPT-80416-RENAL-VEIN-RENIN-MEASUREMENT

    CPT 80416: Renal Vein Renin Measurement Pre- and Post-Stimulant

    CPT-80417-STIMULATED-RENIN-MEASUREMENT

    CPT 80417: Renin Measurement Before and After Captopril Stimulation

    CPT-80418-ANTERIOR-PITUITARY-EVALUATION-PANEL-RAPID

    CPT 80418: Rapid Anterior Pituitary Evaluation Panel

    Showing 1–10 of 22

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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