CPT code 80416 describes renal vein renin sampling: measurement of renin in six renal vein blood samples taken before and after a stimulant such as captopril. This invasive diagnostic procedure is used to evaluate sources of renin secretion and to help distinguish renal-origin causes of hypertension or suspected renovascular conditions. Nationally, accurate coding for this procedure matters for clinical decision support, appropriate utilization of specialized testing, and consistent claims processing.

Key payers included in the analysis are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of what CPT code 80416 represents, the typical clinical and procedural context for use, and the expected sites of service. The publication provides operational benchmarks and coding guidance context, highlights common modifier usage where relevant, and summarizes clinical indications and documentation elements that support medical necessity. For areas where input data are not provided, the text explicitly notes data gaps. The goal is to equip billing professionals, clinical coders, and policy analysts with a clear, national-level reference for CPT code 80416 and its role in renal diagnostic workups.