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    v1.0.30
    OpenPayerBilling CodesEvocative/Suppression Testing ProceduresCPT cpt-80418-anterior-pituitary-evaluation-panel-rapid
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    CPT 80418: Rapid Anterior Pituitary Evaluation Panel

    CPT code 80418 describes a complex combined rapid anterior pituitary evaluation panel in which a laboratory analyst measures seven component analytes, each with four units, typically performed on a serum or plasma sample; this is a laboratory diagnostic service for endocrine function assessment usually provided in a clinical laboratory or hospital lab setting.

    For related coverage guidance, see recent payer policy updates: Diabetic Supplies, Radiofrequency Ablation for Thyroid Nodules, Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only).

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    Clinical & Coding Specifications

    Clinical Context

    A 42-year-old woman presents to endocrinology with months of fatigue, unexplained weight changes, irregular menses, and occasional headaches. Initial screening tests (basic metabolic panel, TSH) are inconclusive. The endocrinologist orders a complex anterior pituitary evaluation panel to measure multiple pituitary-dependent hormone levels simultaneously on a single serum sample to assess pituitary function and guide further testing and imaging.

    The clinical workflow: the patient visits a phlebotomy center or hospital outpatient lab; a blood sample is drawn into serum or plasma tubes, labeled, and sent to the clinical laboratory. A laboratory analyst performs the combined rapid anterior pituitary evaluation panel, measuring each of the seven component analytes with appropriate controls and reporting individual results. Results are reviewed by the ordering endocrinologist, who correlates hormone patterns with clinical findings and decides whether to pursue dynamic endocrine testing, pituitary MRI, or medical therapy. Typical site of service is an outpatient laboratory or hospital outpatient lab; this service is billed as a laboratory procedure when processed by the performing laboratory.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80417Combined rapid anterior pituitary evaluation panel, seven components, performed with fewer units per analyte (example code for a related panel)May be an alternative or predecessor panel; laboratories may bill the most specific panel code that reflects units performed.
    84436Thyroid stimulating hormone (TSH) assayOften ordered alongside pituitary panels to evaluate thyroid axis and differential pituitary vs thyroid dysfunction.
    84443Thyroxine (T4), totalFrequently ordered with pituitary testing to assess peripheral thyroid hormone levels.
    82043Free thyroxine index or free T4 by calculation/assayProvides complementary information to TSH and pituitary hormones in clinical assessment.
    82541ProgesteroneMay be ordered when menstrual irregularity is a presenting symptom to evaluate gonadal axis.
    82142EstradiolCommonly ordered with pituitary panels when evaluating reproductive axis dysfunction.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    208800000X
    171M00000X
    363L00000X
    207RX0202X
    261QP2000X
    225XF0002X
    284300000X

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Diabetic SuppliesCigna2026-10-15
    Radiofrequency Ablation for Thyroid NodulesCigna2026-10-15
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only)UnitedHealthcare2026-10-01
    Tzield (teplizumab-mzwv) CoverageUnitedHealthcare2026-10-01
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Indiana Only)UnitedHealthcare2026-10-01
    Medical Necessity Guidelines Insulin PumpsMass General Brigham Health Plan2026-10-01
    Medical Necessity Guidelines: Continuous Glucose MonitorsMass General Brigham Health Plan2026-10-01
    Continuous Glucose MonitoringAmbetter Nevada2026-10-01
    Salivary Hormone TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01

    Related Codes

    CPT-80400-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80400: ACTH Stimulation Test for Adrenal Function

    CPT-80402-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80402: ACTH Stimulation Test for Adrenal Function

    CPT-80406-ACTH-STIMULATION-TEST-ADRENAL-FUNCTION

    CPT 80406: ACTH Stimulation Test for Adrenal Function

    CPT-80408-ALDOSTERONE-SUPPRESSION-EVALUATION-PANEL-SALINE-INFUSION

    CPT 80408: Aldosterone Suppression Evaluation Panel

    CPT-80410-CALCITONIN-STIMULATION-PANEL-THREE-TESTS

    CPT 80410: Calcitonin Stimulation Panel, Three Measurements

    CPT-80412-CRH-STIMULATION-PANEL-CORTISOL-ACTH-ASSAYS

    CPT 80412: CRH Stimulation Panel with Cortisol and ACTH Assays

    CPT-80414-CHORIONIC-GONADOTROPIN-STIMULATION-TEST-TESTOSTERONE-PANEL

    CPT 80414: Chorionic Gonadotropin Stimulation Panel for Testosterone Response

    CPT-80415-CHORIONIC-GONADOTROPIN-ESTRADIOL-STIMULATION-PANEL

    CPT 80415: Chorionic Gonadotropin Stimulation Estradiol Panel

    CPT-80416-RENAL-VEIN-RENIN-MEASUREMENT

    CPT 80416: Renal Vein Renin Measurement Pre- and Post-Stimulant

    CPT-80417-STIMULATED-RENIN-MEASUREMENT

    CPT 80417: Renin Measurement Before and After Captopril Stimulation

    Showing 1–10 of 22

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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