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    OpenPayerBilling CodesDiagnostic Nuclear Medicine Procedures on the Hematopoietic, Reticuloendothelial and Lymphatic SystemCPT cpt-78130-red-blood-cell-survival-study-autologous-radiolabel
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    CPT 78130: Red Blood Cell Lifespan Study, Radiolabeled Autologous RBC

    Medicare pays $88 on average nationally for this procedure.

    CPT code 78130 describes a red blood cell lifespan study in which the provider labels and injects the patient’s autologous red blood cells with a radiopharmaceutical and measures erythrocyte survival over time; this is a nuclear medicine diagnostic procedure typically performed in an outpatient nuclear medicine department or hospital imaging center and billed as a specialized laboratory/diagnostic service.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient with chronic anemia of unclear etiology is referred for a red blood cell (RBC) survival study to quantify RBC lifespan and evaluate hemolysis. The procedure begins in a nuclear medicine department. The patient has venous access for blood draw; autologous RBCs are drawn, labeled ex vivo with a technetium-99m or similar radiopharmaceutical, and reinjected. Serial blood samples and/or imaging are obtained over several hours to days to track labeled RBC disappearance. Results are interpreted by a nuclear medicine physician or hematologist and reported to the referring clinician to guide diagnosis of hemolytic anemia, evaluate transfusion efficacy, or assess suspected shortened RBC survival due to alloimmune hemolysis or mechanical destruction from prosthetic valves.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    78291Directed blood-pool imaging, single area; richiesta for RBC labeling and imagingPerformed when imaging of tagged RBC distribution or pooling is needed in conjunction with RBC survival assessment.
    78300Whole body bone scan, if applicable (note: example of nuclear imaging)Not directly used for RBC survival but listed as an example of nuclear medicine imaging workflows performed in the same department.
    36415Collection of venous blood by venipunctureRequired to obtain autologous blood for labeling and for serial blood samples during the survival study.
    99000Handling and/or conveyance of specimen (carrier fees) — not current CPT; example onlySome facilities bill specimen handling fees or use facility-specific codes for processing labeled specimens.
    92626Not related; included only as placeholder — omitted if strict rules apply.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208D00000X
    207RH0000X
    2084P0800X
    207LC0200X
    364SE0003X
    152WP0200X
    207QP0002X
    305R00000X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    B37.7Candidal sepsis
    C83.30Diffuse large B-cell lymphoma, unspecified site
    C85.90Non-Hodgkin lymphoma, unspecified, unspecified site
    D50.9Iron deficiency anemia, unspecified
    D56.9Thalassemia, unspecified
    D57.1Sickle-cell disease without crisis
    D63.1Anemia in chronic kidney disease
    D64.9Anemia, unspecified
    E85.9Amyloidosis, unspecified
    I74.9Embolism and thrombosis of unspecified artery

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Nephrology1 / 2

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-78102-LIMITED-AREA-BONE-IMAGING-NUCLEAR-MEDICINE

    CPT 78102: Limited-Area Bone Imaging (Nuclear Medicine)

    CPT-78103-NUCLEAR-MEDICINE-BONE-SCAN

    CPT 78103: Multisite Bone Scintigraphy (Nuclear Medicine)

    CPT-78104-WHOLE-BODY-BONE-SCAN

    CPT 78104: Whole-Body Radionuclide Skeletal Scan

    CPT-78110-SINGLE-SAMPLE-PLASMA-VOLUME-DETERMINATION

    CPT 78110: Single-Sample Radioisotope Plasma Volume Determination

    CPT-78111-PLASMA-VOLUME-MULTIPLE-SAMPLE-METHOD

    CPT 78111: Plasma Volume Determination, Multiple Sample Method

    CPT-78120-RADIOLABELED-SINGLE-SAMPLE-RED-CELL-VOLUME

    CPT 78120: Single-Sample Radioisotope Red Cell Volume Determination

    CPT-78121-RED-CELL-VOLUME-MULTIPLE-SAMPLE-METHOD

    CPT 78121: Red Cell Volume by Multiple-Sample Radioisotope Method

    CPT-78122-WHOLE-BLOOD-VOLUME-STUDY-ISOTOPE-DILUTION

    CPT 78122: Whole Blood Volume Study by Isotope Dilution

    CPT-78140-LIVER-SPLEEN-RADIOLABELED-RED-BLOOD-CELL-SCAN

    CPT 78140: Liver and Spleen Scan with Radiolabeled Red Blood Cells

    CPT-78185-SPLEEN-RADIONUCLIDE-SCAN-SPLENIC-IMAGING

    CPT 78185: Radionuclide Spleen Study for Size/Position and Lesion Detection

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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