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    OpenPayerBilling CodesDiagnostic Nuclear Medicine Procedures on the Hematopoietic, Reticuloendothelial and Lymphatic SystemCPT cpt-78103-nuclear-medicine-bone-scan
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    CPT 78103: Multisite Bone Scintigraphy (Nuclear Medicine)

    Medicare pays $119 on average nationally for this procedure.

    CPT code 78103 describes a noninvasive bone scintigraphy study in which a radiopharmaceutical is administered intravenously and images of bone tissue are acquired as the radiotracer distributes and collects; this service is typically performed as a nuclear medicine bone scan that may image multiple body sites and be conducted in multiple phases, with the service usually provided in an outpatient imaging center or hospital nuclear medicine department.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old male with progressive, diffuse bone pain and a history of metastatic prostate cancer is referred for a diagnostic whole-body bone scintigraphy. The nuclear medicine technologist establishes IV access, administers the technetium-99m-labeled radiopharmaceutical, and documents injection time and activity. The patient waits 2–4 hours for optimal skeletal uptake while hydration and voiding are encouraged. Multiple-phase imaging is performed: immediate flow images (if indicated for suspected osteomyelitis or fracture), blood-pool images, and delayed whole-body planar images with spot views of symptomatic regions. A nuclear medicine physician reviews the images, compares prior imaging (radiographs, CT, MRI), and issues a signed report describing radiotracer distribution, focal increased uptake suggestive of metastatic disease, fracture, infection, or degenerative change. Results are communicated to the referring oncologist or orthopedic surgeon for next-step management such as targeted radiography, MRI, biopsy, or oncologic treatment planning.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    71020Radiologic examination, chest, 2 views, frontal and lateralPerformed to evaluate pulmonary nodules or infection when metastatic disease or infection is suspected concurrently.
    72148Magnetic resonance (e.g., of pelvis) without contrast, high-resolutionUsed for targeted evaluation of suspicious pelvic or sacral lesions identified on the bone scan.
    78800Radiopharmaceutical localization of tumor or distribution of radiolabeled agent, planarRelated nuclear medicine procedures for tumor localization; may be used for different agents or targeted studies.
    78306Bone imaging, whole body, delayed imagesAlternate code often used for whole-body bone scans; used depending on payer coding guidance and specific technique.
    76098Radiologic examination (eg, soft tissue); remote imaging with technologist and immediate interpretationUsed when spot radiographs accompany the bone scan for correlation of focal uptake.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    332B00000X
    1835C0206X
    1744G0900X
    225200000X
    385H00000X
    364SC1501X
    317400000X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    C79.51Secondary malignant neoplasm of bone
    C79.52Secondary malignant neoplasm of bone marrow
    C90.00Multiple myeloma not having achieved remission
    D49.2Neoplasm of unspecified behavior of bone, soft tissue, and skin
    D49.6Neoplasm of unspecified behavior of brain
    M06.9Rheumatoid arthritis, unspecified
    M16.11Unilateral primary osteoarthritis, right hip
    M16.12Unilateral primary osteoarthritis, left hip
    M17.11Unilateral primary osteoarthritis, right knee
    M17.12Unilateral primary osteoarthritis, left knee

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Nephrology1 / 2

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-78102-LIMITED-AREA-BONE-IMAGING-NUCLEAR-MEDICINE

    CPT 78102: Limited-Area Bone Imaging (Nuclear Medicine)

    CPT-78104-WHOLE-BODY-BONE-SCAN

    CPT 78104: Whole-Body Radionuclide Skeletal Scan

    CPT-78110-SINGLE-SAMPLE-PLASMA-VOLUME-DETERMINATION

    CPT 78110: Single-Sample Radioisotope Plasma Volume Determination

    CPT-78111-PLASMA-VOLUME-MULTIPLE-SAMPLE-METHOD

    CPT 78111: Plasma Volume Determination, Multiple Sample Method

    CPT-78120-RADIOLABELED-SINGLE-SAMPLE-RED-CELL-VOLUME

    CPT 78120: Single-Sample Radioisotope Red Cell Volume Determination

    CPT-78121-RED-CELL-VOLUME-MULTIPLE-SAMPLE-METHOD

    CPT 78121: Red Cell Volume by Multiple-Sample Radioisotope Method

    CPT-78122-WHOLE-BLOOD-VOLUME-STUDY-ISOTOPE-DILUTION

    CPT 78122: Whole Blood Volume Study by Isotope Dilution

    CPT-78130-RED-BLOOD-CELL-SURVIVAL-STUDY-AUTOLOGOUS-RADIOLABEL

    CPT 78130: Red Blood Cell Lifespan Study, Radiolabeled Autologous RBC

    CPT-78140-LIVER-SPLEEN-RADIOLABELED-RED-BLOOD-CELL-SCAN

    CPT 78140: Liver and Spleen Scan with Radiolabeled Red Blood Cells

    CPT-78185-SPLEEN-RADIONUCLIDE-SCAN-SPLENIC-IMAGING

    CPT 78185: Radionuclide Spleen Study for Size/Position and Lesion Detection

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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