CPT code 78110 denotes a single-sample plasma volume determination using an injected radioactive tracer and post-mixing concentration measurement. This nuclear medicine diagnostic procedure quantifies plasma volume, informing fluid management, hematologic assessment, and preprocedural evaluations. Nationally, accurate reporting of this code supports clinical decision-making and proper classification of nuclear medicine services.

Key payers in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find an orientation to the clinical purpose of the test, typical sites of service (hospital outpatient, inpatient, and freestanding imaging/nuclear medicine clinics), and the role of the single-sample method relative to other plasma volume measurement techniques.

The publication provides benchmarks and coding context where available, explains common use cases and clinical scenarios in which a plasma volume study is ordered, and summarizes implications for billing workflows. Data not available in the input is identified explicitly. This summary is aimed at clinicians, coding professionals, and policy analysts seeking a concise reference to the clinical intent and billing context of CPT code 78110 on a national level.