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    OpenPayerBilling CodesDiagnostic Nuclear Medicine Procedures on the Hematopoietic, Reticuloendothelial and Lymphatic SystemCPT cpt-78120-radiolabeled-single-sample-red-cell-volume
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    CPT 78120: Single-Sample Radioisotope Red Cell Volume Determination

    Medicare pays $50 on average nationally for this procedure.

    CPT code 78120 describes a single-sample radioisotope red cell volume determination in which a known quantity of radiolabeled red blood cells is introduced and the concentration is measured after adequate mixing; this diagnostic nuclear medicine procedure is typically performed as an outpatient or hospital-based laboratory test to assess red blood cell volume and related hematologic status.

    For related coverage guidance, see recent payer policy updates: Vafseo (vadadustat) for anemia in CKD on dialysis, Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family Plans, Kerendia (finerenone) — Coverage Criteria.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult referred to a nuclear medicine or hematology service to quantify circulating red cell mass when there is concern for unexplained anemia, polycythemia, hemolysis, or evaluation of blood volume disorders. The patient arrives to an outpatient nuclear medicine suite or hospital radiology/hematology lab. After informed consent, baseline vital signs and intravenous access are obtained. A measured aliquot of the patient’s autologous red blood cells is labeled ex vivo or in vivo with a radioactive tracer (commonly technetium-99m) and a known activity is injected back to the patient. After adequate mixing time, a single blood sample is drawn at the specified interval to measure radioactivity and calculate red cell volume using the single-sample technique represented by 78120. Results are reviewed by the ordering physician (hematologist or nuclear medicine physician) to guide diagnosis and management, such as distinguishing true polycythemia from relative erythrocytosis, assessing blood loss, or evaluating marrow production in anemia.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36415Collection of venous blood by venipuncturePreceding step for baseline and post-injection samples required for 78120.
    36416Collection of capillary blood specimenAlternative sampling method when venipuncture is difficult; may be used for single-sample assays.
    78620Non-vascular radiopharmaceutical localization of a single organ systemRelated nuclear medicine techniques; not specific but in same domain of radionuclide studies and lab workflows.
    88305Level IV surgical pathology, gross and microscopic examinationAncillary: used when concurrent bone marrow biopsy specimens are evaluated in hematology workups that include red cell mass studies.
    93000Electrocardiogram, routine ECG with at least 12 leads; with interpretation and reportPerformed as part of pre-procedural evaluation when indicated for patients with cardiovascular risk undergoing radionuclide procedures.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2080P0206X
    2084N0400X
    207K00000X
    163WX0800X
    1223X0008X
    246ZB0301X
    2080P0008X
    207KA0200X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C50.919Malignant neoplasm of unspecified site of unspecified female breast
    C77.9Secondary and unspecified malignant neoplasm of lymph node, unspecified
    D50.0Iron deficiency anemia secondary to blood loss (chronic)
    D50.9Iron deficiency anemia, unspecified
    D51.0Vitamin B12 deficiency anemia due to intrinsic factor deficiency
    D53.9Nutritional anemia, unspecified
    D55.9Anemia due to enzyme disorder, unspecified
    D56.9Thalassemia, unspecified
    D62Acute posthemorrhagic anemia

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Nephrology1 / 2

    10 rows

    PolicyPayerEffective Date
    Vafseo (vadadustat) for anemia in CKD on dialysisCigna2026-08-15
    Metabolic Disorders - Cysteamine (Oral) Products for Individual and Family PlansCigna2026-08-15
    Kerendia (finerenone) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-05
    Voyxact (sibeprenlimab-szsl) — Prior authorization / medical necessity for primary IgA nephropathyColorado Rocky Mountain Health Plans2026-08-01
    Oxlumo (lumasiran) and Rivfloza (nedosiran) — Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Korsuva (difelikefalin) — Medical Benefit Drug Coverage Criteria (Ohio)Colorado Rocky Mountain Health Plans2026-08-01
    Complement Inhibitors - EmpaveliCigna2026-08-01
    Tolvaptan (Jynarque)Cigna2026-08-01
    Nephrology - Filspari (sparsentan) coverageCigna2026-08-01
    Rivfloza (nedosiran) prior authorization for PH1UnitedHealthcare2026-08-01

    Related Codes

    CPT-78102-LIMITED-AREA-BONE-IMAGING-NUCLEAR-MEDICINE

    CPT 78102: Limited-Area Bone Imaging (Nuclear Medicine)

    CPT-78103-NUCLEAR-MEDICINE-BONE-SCAN

    CPT 78103: Multisite Bone Scintigraphy (Nuclear Medicine)

    CPT-78104-WHOLE-BODY-BONE-SCAN

    CPT 78104: Whole-Body Radionuclide Skeletal Scan

    CPT-78110-SINGLE-SAMPLE-PLASMA-VOLUME-DETERMINATION

    CPT 78110: Single-Sample Radioisotope Plasma Volume Determination

    CPT-78111-PLASMA-VOLUME-MULTIPLE-SAMPLE-METHOD

    CPT 78111: Plasma Volume Determination, Multiple Sample Method

    CPT-78121-RED-CELL-VOLUME-MULTIPLE-SAMPLE-METHOD

    CPT 78121: Red Cell Volume by Multiple-Sample Radioisotope Method

    CPT-78122-WHOLE-BLOOD-VOLUME-STUDY-ISOTOPE-DILUTION

    CPT 78122: Whole Blood Volume Study by Isotope Dilution

    CPT-78130-RED-BLOOD-CELL-SURVIVAL-STUDY-AUTOLOGOUS-RADIOLABEL

    CPT 78130: Red Blood Cell Lifespan Study, Radiolabeled Autologous RBC

    CPT-78140-LIVER-SPLEEN-RADIOLABELED-RED-BLOOD-CELL-SCAN

    CPT 78140: Liver and Spleen Scan with Radiolabeled Red Blood Cells

    CPT-78185-SPLEEN-RADIONUCLIDE-SCAN-SPLENIC-IMAGING

    CPT 78185: Radionuclide Spleen Study for Size/Position and Lesion Detection

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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