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    v1.0.28
    OpenPayerBilling CodesProtozoal diseasesICD-10-CM b64-unspecified-protozoal-disease
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    ICD-10-CM Code For Unspecified Protozoal Disease: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group B64 includes nonspecific protozoal infections where the causative protozoan or the clinical syndrome is not identified, covering systemic and organ-specific presentations attributable to protozoa. These ICD-10-CM diagnosis codes are used to document clinical encounters where a protozoal infection is diagnosed but the organism or precise clinical manifestation remains unspecified, capturing disease severity or extent when specific codes are not applicable. Accurate coding within the ICD-10-CM B64 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM B64: Unspecified Protozoal Disease Overview

    The ICD-10-CM B64 group represents diagnoses for protozoal infections not specified to a particular organism or clinical syndrome, generally affecting multiple organ systems depending on the pathogen and host response. These conditions target infectious disease processes caused by single-celled eukaryotic organisms and may involve gastrointestinal, hepatic, neurologic, or systemic manifestations. Accurate coding is important for complete clinical documentation and can affect reimbursement and public health surveillance.

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    When to Use

    Use a code from this group when a clinician documents a protozoal infection without specifying the causative organism or a more specific protozoal disease code. Choose these codes when laboratory confirmation is absent or when the clinical record does not support assignment of a more specific protozoal diagnosis.

    ICD-10-CM Codes

    1 rows

    ICD-10-CM CodeDescription
    B64Unspecified protozoal disease

    DRG Codes

    3 rows

    DRG CodeDescription
    867Other Infectious and Parasitic Diseases Diagnoses with MCC
    868Other Infectious and Parasitic Diseases Diagnoses with CC
    869Other Infectious and Parasitic Diseases Diagnoses without CC/MCC

    Typical Clinical Scenarios

    • An adult patient presents to the emergency department with fever, malaise, and profuse watery diarrhea after returning from travel to a tropical region; stool studies are non-diagnostic and no specific protozoan organism is identified, so clinicians document an unspecified protozoal infection pending further testing or when definitive organism identification is not possible. Typical codes: B64.
    • An elderly nursing home resident has ongoing intermittent gastrointestinal symptoms and weight loss over several months; repeated stool exams fail to identify a specific protozoal pathogen, and the care team assigns a non-specific protozoal disease diagnosis to indicate chronic symptomatic infection without confirmed organism. Typical codes: B64.
    • A hospitalized immunocompromised patient (on chemotherapy) develops unexplained fever and systemic symptoms suggestive of protozoal infection, but blood and tissue studies are inconclusive; the treating team documents an unspecified protozoal disease as a comorbidity affecting management while further workup is performed. Typical codes: B64.

    Related Codes

    B50-PLASMODIUM-FALCIPARUM-MALARIA

    ICD-10-CM Code For Plasmodium Falciparum Malaria: Group Overview

    B52-PLASMODIUM-MALARIAE-MALARIA

    ICD-10-CM Code For Plasmodium Malariae Malaria: Group Overview

    B53-OTHER-SPECIFIED-MALARIA

    ICD-10-CM Code For Other Specified Malaria: Group Overview

    B54-UNSPECIFIED-MALARIA

    ICD-10-CM Code For Unspecified Malaria: Group Overview

    B55-LEISHMANIASIS

    ICD-10-CM Code For Leishmaniasis: Group Overview

    B56-AFRICAN-TRYPANOSOMIASIS

    ICD-10-CM Code For African Trypanosomiasis: Group Overview

    B57-CHAGAS-DISEASE

    ICD-10-CM Code For Chagas' Disease: Group Overview

    B58-TOXOPLASMOSIS

    ICD-10-CM Code For Toxoplasmosis: Group Overview

    B59-PNEUMOCYSTOSIS

    ICD-10-CM Code For Pneumocystosis: Group Overview

    B60-OTHER-PROTOZOAL-DISEASES

    ICD-10-CM Code For Other Protozoal Diseases Not Elsewhere Classified: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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