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    v1.0.28
    OpenPayerBilling CodesProtozoal diseasesICD-10-CM b50-plasmodium-falciparum-malaria
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    ICD-10-CM Code For Plasmodium Falciparum Malaria: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group B50 includes diagnoses for infection with Plasmodium falciparum, covering uncomplicated and severe malaria and associated complications. These ICD-10-CM diagnosis codes are used to document clinical scenarios such as parasitemia, cerebral involvement, severe anemia, renal failure, or other organ dysfunction related to falciparum malaria, capturing disease severity and complication status. Accurate coding within the ICD-10-CM B50 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM B50: Plasmodium falciparum malaria Overview

    The ICD-10-CM B50 group encompasses diagnoses for infection with Plasmodium falciparum, a protozoal parasite that primarily affects the blood and can cause severe systemic illness. These codes target malarial disease manifestations and complications affecting hematologic and multi-organ systems. Accurate coding matters for reimbursement because it documents disease severity and complications that influence claim adjudication and payment.

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    When to Use

    Use a code from this group when clinical documentation indicates infection with Plasmodium falciparum confirmed or strongly suspected by laboratory, clinical, or epidemiologic findings. Select the specific code that corresponds to the presence or absence of severe manifestations or organ system complications as documented in the medical record.

    ICD-10-CM Codes

    3 rows

    ICD-10-CM CodeDescription
    B50.0Plasmodium falciparum malaria with cerebral complications
    B50.8Other severe and complicated Plasmodium falciparum malaria
    B50.9Plasmodium falciparum malaria, unspecified

    DRG Codes

    3 rows

    DRG CodeDescription
    867Other Infectious and Parasitic Diseases Diagnoses with MCC
    868Other Infectious and Parasitic Diseases Diagnoses with CC
    869Other Infectious and Parasitic Diseases Diagnoses without CC/MCC

    Typical Clinical Scenarios

    • An adult traveler returns from sub-Saharan Africa with high fever, rigors, headache, and progressive confusion over 48 hours; laboratory testing reveals intraerythrocytic ring forms on blood smear and a high parasitemia percentage consistent with severe falciparum infection, and the patient requires urgent antimalarial therapy and inpatient monitoring. A diagnosis from this group is assigned because Plasmodium falciparum is confirmed as the etiologic agent causing the acute febrile illness. Typical codes: B50.0, B50.9
    • A pregnant woman presents during routine prenatal care with low-grade fever and mild anemia after recent travel to an endemic area; a peripheral smear demonstrates P. falciparum trophozoites but without signs of severe disease, and she is managed outpatient with pregnancy-appropriate antimalarial treatment and follow-up. A diagnosis from this group is assigned to document active uncomplicated falciparum malaria affecting a special population (pregnancy) needing tailored management. Typical codes: B50.9
    • A person with known falciparum malaria develops acute renal failure and metabolic complications while hospitalized; the renal dysfunction is assessed as a complication of the malaria infection and is coded alongside the parasite diagnosis to indicate malaria as the underlying cause. A diagnosis from this group is assigned to identify Plasmodium falciparum as the etiologic agent responsible for the systemic complication. Typical codes: B50.8, B50.0

    Related Codes

    B52-PLASMODIUM-MALARIAE-MALARIA

    ICD-10-CM Code For Plasmodium Malariae Malaria: Group Overview

    B53-OTHER-SPECIFIED-MALARIA

    ICD-10-CM Code For Other Specified Malaria: Group Overview

    B54-UNSPECIFIED-MALARIA

    ICD-10-CM Code For Unspecified Malaria: Group Overview

    B55-LEISHMANIASIS

    ICD-10-CM Code For Leishmaniasis: Group Overview

    B56-AFRICAN-TRYPANOSOMIASIS

    ICD-10-CM Code For African Trypanosomiasis: Group Overview

    B57-CHAGAS-DISEASE

    ICD-10-CM Code For Chagas' Disease: Group Overview

    B58-TOXOPLASMOSIS

    ICD-10-CM Code For Toxoplasmosis: Group Overview

    B59-PNEUMOCYSTOSIS

    ICD-10-CM Code For Pneumocystosis: Group Overview

    B60-OTHER-PROTOZOAL-DISEASES

    ICD-10-CM Code For Other Protozoal Diseases Not Elsewhere Classified: Group Overview

    B64-UNSPECIFIED-PROTOZOAL-DISEASE

    ICD-10-CM Code For Unspecified Protozoal Disease: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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