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    v1.0.28
    OpenPayerBilling CodesProtozoal diseasesICD-10-CM b53-other-specified-malaria
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    ICD-10-CM Code For Other Specified Malaria: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group B53 includes specified types of malaria infections caused by identified Plasmodium species not classified elsewhere, and other specified malaria presentations. These ICD-10-CM diagnosis codes are used to document clinical scenarios such as confirmed parasitic infection with species identification, manifestations involving hematologic or organ complications, and differing levels of disease severity. Accurate coding within the ICD-10-CM B53 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM B53: Other Specified Malaria Overview

    The diagnoses in this group represent specified forms of malaria caused by various Plasmodium species other than the most common classifications. These conditions target the blood and can result in systemic illness with fever, hemolysis, and organ dysfunction in severe cases. Accurate coding is important to reflect clinical severity, guide appropriate claim processing, and support correct reimbursement.

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    When to Use

    Use a code from this group when a clinician documents a confirmed malaria infection that is specified as an other type or when species identification places the case in an other specified category. Select codes from this group to reflect clinical details such as organ involvement, severity, or documented species when not classified under primary malaria codes.

    ICD-10-CM Codes

    3 rows

    ICD-10-CM CodeDescription
    B53.0Plasmodium ovale malaria
    B53.1Malaria due to simian plasmodia
    B53.8Other malaria, not elsewhere classified

    DRG Codes

    3 rows

    DRG CodeDescription
    867Other Infectious and Parasitic Diseases Diagnoses with MCC
    868Other Infectious and Parasitic Diseases Diagnoses with CC
    869Other Infectious and Parasitic Diseases Diagnoses without CC/MCC

    Typical Clinical Scenarios

    • An adult traveler returns from a short trip to Southeast Asia with high fever, chills, rigors, headache, and myalgias beginning 1–2 weeks after return; peripheral blood smear shows Plasmodium falciparum with low to moderate parasitemia and there is concern for an acute malarial infection that is not classified as vivax/ovale or falciparum in documentation. The patient presents to urgent care for prompt antimalarial treatment and confirmation; a code from this group is assigned to capture a specified nonstandard malaria diagnosis. Typical codes: B53.0
    • A child from a malaria-endemic region is seen in outpatient infectious disease follow-up for recurrent febrile episodes after partial treatment received abroad; laboratory testing identifies Plasmodium malariae as the etiologic agent with persistent low-level parasitemia and intermittent symptoms over months. The chronic, relapsing nature of the illness requires ongoing monitoring and management, so a code from this group is used to document the specified nonfalciparum, non-vivax infection. Typical codes: B53.1
    • An adult hospitalized for severe anemia and splenomegaly during an acute febrile illness after travel has blood tests positive for mixed or unspecified malaria species where documentation specifies a malaria infection not otherwise categorized; the malaria contributes to the hospitalization and complicates management of comorbid conditions. Inpatient coders assign a specific code from this group to reflect the other specified malaria diagnosis as a principal or secondary condition. Typical codes: B53.8

    Related Codes

    B50-PLASMODIUM-FALCIPARUM-MALARIA

    ICD-10-CM Code For Plasmodium Falciparum Malaria: Group Overview

    B52-PLASMODIUM-MALARIAE-MALARIA

    ICD-10-CM Code For Plasmodium Malariae Malaria: Group Overview

    B54-UNSPECIFIED-MALARIA

    ICD-10-CM Code For Unspecified Malaria: Group Overview

    B55-LEISHMANIASIS

    ICD-10-CM Code For Leishmaniasis: Group Overview

    B56-AFRICAN-TRYPANOSOMIASIS

    ICD-10-CM Code For African Trypanosomiasis: Group Overview

    B57-CHAGAS-DISEASE

    ICD-10-CM Code For Chagas' Disease: Group Overview

    B58-TOXOPLASMOSIS

    ICD-10-CM Code For Toxoplasmosis: Group Overview

    B59-PNEUMOCYSTOSIS

    ICD-10-CM Code For Pneumocystosis: Group Overview

    B60-OTHER-PROTOZOAL-DISEASES

    ICD-10-CM Code For Other Protozoal Diseases Not Elsewhere Classified: Group Overview

    B64-UNSPECIFIED-PROTOZOAL-DISEASE

    ICD-10-CM Code For Unspecified Protozoal Disease: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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