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    v1.0.28
    OpenPayerBilling CodesInfections with a predominantly sexual mode of transmissionICD-10-CM a52-late-syphilis
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    ICD-10-CM Code For Late Syphilis: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group A52 includes late manifestations of syphilis such as neurosyphilis, cardiovascular syphilis, and other tertiary syphilitic conditions resulting from chronic Treponema pallidum infection. These ICD-10-CM diagnosis codes are used to document advanced disease presentations, organ system involvement, and clinical complexity relevant to late syphilis. Accurate coding within the ICD-10-CM A52 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM A52: Late Syphilis Overview

    The diagnoses in the International Classification of Diseases, Tenth Revision, Clinical Modification code group A52 represent manifestations of late syphilis, including tertiary and late latent stages that can affect multiple organ systems. These conditions target neurologic, cardiovascular, and other systemic complications resulting from untreated or inadequately treated Treponema pallidum infection. Accurate coding matters for correct clinical documentation and reimbursement because it captures disease severity, complications, and the need for specific management.

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    When to Use

    Use a code from this group when clinical documentation indicates late-stage syphilis such as neurosyphilis, aortitis, or other tertiary presentations rather than primary or secondary disease. Select the specific code that reflects the documented organ system involvement and clinical manifestations to accurately represent severity and complexity.

    ICD-10-CM Codes

    30 rows

    ICD-10-CM CodeDescription
    A52.00Cardiovascular syphilis, unspecified
    A52.01Syphilitic aneurysm of aorta
    A52.02Syphilitic aortitis
    A52.03Syphilitic endocarditis
    A52.04Syphilitic cerebral arteritis
    A52.05Other cerebrovascular syphilis
    A52.06Other syphilitic heart involvement
    A52.09Other cardiovascular syphilis
    A52.10Symptomatic neurosyphilis, unspecified
    A52.11Tabes dorsalis
    A52.12Other cerebrospinal syphilis
    A52.13Late syphilitic meningitis
    A52.14Late syphilitic encephalitis
    A52.15Late syphilitic neuropathy
    A52.16Charcot's arthropathy (tabetic)
    A52.17General paresis
    A52.19Other symptomatic neurosyphilis
    A52.2Asymptomatic neurosyphilis
    A52.3Neurosyphilis, unspecified
    A52.71Late syphilitic oculopathy

    Showing 1–20 of 30

    DRG Codes

    33 rows

    DRG CodeDescription
    023Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis with MCC or Antineoplastic Implant or Epilepsy with Neurostimulator
    024Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis without MCC
    056Degenerative Nervous System Disorders with MCC
    057Degenerative Nervous System Disorders without MCC
    097Non-Bacterial Infection of Nervous System Except Viral Meningitis with MCC
    098Non-Bacterial Infection of Nervous System Except Viral Meningitis with CC
    099Non-Bacterial Infection of Nervous System Except Viral Meningitis without CC/MCC
    124Other Disorders of the Eye with MCC or Thrombolytic Agent
    125Other Disorders of the Eye without MCC
    177Respiratory Infections and Inflammations with MCC
    178Respiratory Infections and Inflammations with CC
    179Respiratory Infections and Inflammations without CC/MCC
    288Acute and Subacute Endocarditis with MCC
    289Acute and Subacute Endocarditis with CC
    290Acute and Subacute Endocarditis without CC/MCC
    306Cardiac Congenital and Valvular Disorders with MCC
    307Cardiac Congenital and Valvular Disorders without MCC
    314Other Circulatory System Diagnoses with MCC
    315Other Circulatory System Diagnoses with CC
    316Other Circulatory System Diagnoses without CC/MCC

    Showing 1–20 of 33

    Typical Clinical Scenarios

    • An older adult with progressive cognitive decline, personality changes, gait disturbance, and broad-based ataxia presents to neurology after family members observe worsening memory and mood over months. CSF VDRL and serum treponemal tests are positive, and neuroimaging shows cortical atrophy consistent with a chronic meningoencephalitic process; a diagnosis from this group is assigned for late neurosyphilis to capture central nervous system involvement. Typical codes: A52.11, A52.12
    • A middle-aged patient develops a chronic, painless indurated ulcer on the penis and multiple rubbery regional lymphadenopathies months after an untreated chancre; on further evaluation they have serologic evidence of syphilis and signs of tertiary gummatous skin lesions and destructive nasal cartilage changes. Because these represent late, destructive mucocutaneous manifestations of untreated infection, a late syphilis code reflecting gummatous disease is assigned at the visit. Typical codes: A52.7, A52.71, A52.72
    • A patient with a long history of untreated syphilis is evaluated in primary care for progressive cardiovascular symptoms including new onset heart failure symptoms and a wide pulse pressure; imaging shows a thoracic aortic aneurysm thought to be due to syphilitic aortitis. This visit documents a late cardiovascular complication of treponemal infection, and a late syphilis code for cardiovascular involvement is used to capture the comorbidity. Typical codes: A52.0, A52.01

    Related Codes

    A50-CONGENITAL-SYPHILIS

    ICD-10-CM Code For Congenital Syphilis: Group Overview

    A51-EARLY-SYPHILIS

    ICD-10-CM Code For Early Syphilis: Group Overview

    A53-OTHER-AND-UNSPECIFIED-SYPHILIS

    ICD-10-CM Code For Other And Unspecified Syphilis: Group Overview

    A54-GONOCOCCAL-INFECTION

    ICD-10-CM Code For Gonococcal Infection: Group Overview

    A55-CHLAMYDIAL-LYMPHOGRANULOMA-VENEREUM

    ICD-10-CM Code For Chlamydial Lymphogranuloma (Venereum): Group Overview

    A56-OTHER-SEXUALLY-TRANSMITTED-CHLAMYDIAL-DISEASES

    ICD-10-CM Code For Other Sexually Transmitted Chlamydial Diseases: Group Overview

    A57-CHANCROID

    ICD-10-CM Code For Chancroid: Group Overview

    A58-GRANULOMA-INGUINALE

    ICD-10-CM Code For Granuloma Inguinale: Group Overview

    A59-TRICHOMONIASIS

    ICD-10-CM Code For Trichomoniasis: Group Overview

    A60-ANOGENITAL-HERPESVIRAL-INFECTIONS

    ICD-10-CM Code For Anogenital Herpesviral Infections: Group Overview

    Showing 1–10 of 12

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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