ICD-10-CM Code For Congenital Syphilis: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group A50 includes diagnoses for congenital syphilis and its various clinical manifestations in neonates and infants, such as early symptomatic congenital infection, latent congenital infection, and late congenital sequelae. These ICD-10-CM diagnosis codes are used to document clinical scenarios involving transplacental Treponema pallidum infection, capturing disease severity, organ system involvement, and timing of onset. Accurate coding within the ICD-10-CM A50 group supports complete clinical documentation and appropriate reimbursement.

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ICD-10-CM A50: Congenital Syphilis Overview

The diagnoses in this group represent infections caused by transplacental transmission of Treponema pallidum resulting in clinical disease in the neonate and infant. These codes target congenital infection and its manifestations across organ systems, including neurologic, dermatologic, skeletal, and systemic involvement. Accurate coding matters for appropriate clinical documentation and reimbursement because it captures disease severity and guides care coordination.

When to Use

Use a code from this group when documenting congenital syphilis confirmed or strongly suspected in a neonate or infant, including specified clinical manifestations or timing of onset. Select the code that best reflects the clinical presentation, organ system involvement, and whether the infection is early, late, or latent.

ICD-10-CM Codes

33 rows

ICD-10-CM Code	Description
A50.01	Early congenital syphilitic oculopathy
A50.02	Early congenital syphilitic osteochondropathy
A50.03	Early congenital syphilitic pharyngitis
A50.04	Early congenital syphilitic pneumonia
A50.05	Early congenital syphilitic rhinitis
A50.06	Early cutaneous congenital syphilis
A50.07	Early mucocutaneous congenital syphilis
A50.08	Early visceral congenital syphilis
A50.09	Other early congenital syphilis, symptomatic
A50.1	Early congenital syphilis, latent
A50.2	Early congenital syphilis, unspecified
A50.30	Late congenital syphilitic oculopathy, unspecified
A50.31	Late congenital syphilitic interstitial keratitis
A50.32	Late congenital syphilitic chorioretinitis
A50.39	Other late congenital syphilitic oculopathy
A50.40	Late congenital neurosyphilis, unspecified
A50.41	Late congenital syphilitic meningitis
A50.42	Late congenital syphilitic encephalitis
A50.43	Late congenital syphilitic polyneuropathy
A50.44	Late congenital syphilitic optic nerve atrophy

Showing 1–20 of 33

DRG Codes

8 rows

DRG Code	Description
097	Non-Bacterial Infection of Nervous System Except Viral Meningitis with MCC
098	Non-Bacterial Infection of Nervous System Except Viral Meningitis with CC
099	Non-Bacterial Infection of Nervous System Except Viral Meningitis without CC/MCC
124	Other Disorders of the Eye with MCC or Thrombolytic Agent
125	Other Disorders of the Eye without MCC
867	Other Infectious and Parasitic Diseases Diagnoses with MCC
868	Other Infectious and Parasitic Diseases Diagnoses with CC
869	Other Infectious and Parasitic Diseases Diagnoses without CC/MCC

Typical Clinical Scenarios

A newborn delivered at term in a community hospital presents with hepatosplenomegaly, nasal discharge, a maculopapular rash, and abnormal long-bone x-rays on the first neonatal exam; the mother had inadequate or no prenatal syphilis treatment. The infant is evaluated by the newborn team and pediatric infectious disease for suspected congenital infection and receives serologic testing and lumbar puncture. A diagnosis from this group is assigned for early symptomatic congenital infection when systemic signs are present at or shortly after birth. Typical codes: A50.0, A50.1, A50.3.
An infant aged 3 months is brought to clinic for failure to thrive, snuffles, anemia, and persistent skin desquamation; the birth history notes maternal untreated syphilis and delayed follow-up. Outpatient evaluation documents ongoing manifestations of congenital infection and longitudinal management by pediatric specialists; a code from this group is used to indicate late-presenting congenital syphilis with active clinical findings requiring continued treatment and monitoring. Typical codes: A50.4, A50.5.
A school-aged child with a history of treated congenital infection in infancy is hospitalized with sensorineural hearing loss and dental abnormalities (noted as sequelae of congenital infection) requiring audiology and dental specialty care. The encounter documents long-term sequelae attributable to prior congenital infection rather than acute systemic disease, so a code from this group for late effects or sequelae is assigned to capture the chronic complication. Typical codes: A50.6, A50.7.

Related Codes

A51-EARLY-SYPHILIS

ICD-10-CM Code For Early Syphilis: Group Overview

A52-LATE-SYPHILIS

ICD-10-CM Code For Late Syphilis: Group Overview

A53-OTHER-AND-UNSPECIFIED-SYPHILIS

ICD-10-CM Code For Other And Unspecified Syphilis: Group Overview

A54-GONOCOCCAL-INFECTION

ICD-10-CM Code For Gonococcal Infection: Group Overview

A55-CHLAMYDIAL-LYMPHOGRANULOMA-VENEREUM

ICD-10-CM Code For Chlamydial Lymphogranuloma (Venereum): Group Overview

A56-OTHER-SEXUALLY-TRANSMITTED-CHLAMYDIAL-DISEASES

ICD-10-CM Code For Other Sexually Transmitted Chlamydial Diseases: Group Overview

A57-CHANCROID

ICD-10-CM Code For Chancroid: Group Overview

A58-GRANULOMA-INGUINALE

ICD-10-CM Code For Granuloma Inguinale: Group Overview

A59-TRICHOMONIASIS

ICD-10-CM Code For Trichomoniasis: Group Overview

A60-ANOGENITAL-HERPESVIRAL-INFECTIONS

ICD-10-CM Code For Anogenital Herpesviral Infections: Group Overview

Showing 1–10 of 12

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-CM Codes

33 rows

ICD-10-CM Code	Description
A50.01	Early congenital syphilitic oculopathy
A50.02	Early congenital syphilitic osteochondropathy
A50.03	Early congenital syphilitic pharyngitis
A50.04	Early congenital syphilitic pneumonia
A50.05	Early congenital syphilitic rhinitis
A50.06	Early cutaneous congenital syphilis
A50.07	Early mucocutaneous congenital syphilis
A50.08	Early visceral congenital syphilis
A50.09	Other early congenital syphilis, symptomatic
A50.1	Early congenital syphilis, latent
A50.2	Early congenital syphilis, unspecified
A50.30	Late congenital syphilitic oculopathy, unspecified
A50.31	Late congenital syphilitic interstitial keratitis
A50.32	Late congenital syphilitic chorioretinitis
A50.39	Other late congenital syphilitic oculopathy
A50.40	Late congenital neurosyphilis, unspecified
A50.41	Late congenital syphilitic meningitis
A50.42	Late congenital syphilitic encephalitis
A50.43	Late congenital syphilitic polyneuropathy
A50.44	Late congenital syphilitic optic nerve atrophy

Showing 1–20 of 33

DRG Codes

8 rows

DRG Code	Description
097	Non-Bacterial Infection of Nervous System Except Viral Meningitis with MCC
098	Non-Bacterial Infection of Nervous System Except Viral Meningitis with CC
099	Non-Bacterial Infection of Nervous System Except Viral Meningitis without CC/MCC
124	Other Disorders of the Eye with MCC or Thrombolytic Agent
125	Other Disorders of the Eye without MCC
867	Other Infectious and Parasitic Diseases Diagnoses with MCC
868	Other Infectious and Parasitic Diseases Diagnoses with CC
869	Other Infectious and Parasitic Diseases Diagnoses without CC/MCC

Typical Clinical Scenarios

A newborn delivered at term in a community hospital presents with hepatosplenomegaly, nasal discharge, a maculopapular rash, and abnormal long-bone x-rays on the first neonatal exam; the mother had inadequate or no prenatal syphilis treatment. The infant is evaluated by the newborn team and pediatric infectious disease for suspected congenital infection and receives serologic testing and lumbar puncture. A diagnosis from this group is assigned for early symptomatic congenital infection when systemic signs are present at or shortly after birth. Typical codes: A50.0, A50.1, A50.3.
An infant aged 3 months is brought to clinic for failure to thrive, snuffles, anemia, and persistent skin desquamation; the birth history notes maternal untreated syphilis and delayed follow-up. Outpatient evaluation documents ongoing manifestations of congenital infection and longitudinal management by pediatric specialists; a code from this group is used to indicate late-presenting congenital syphilis with active clinical findings requiring continued treatment and monitoring. Typical codes: A50.4, A50.5.
A school-aged child with a history of treated congenital infection in infancy is hospitalized with sensorineural hearing loss and dental abnormalities (noted as sequelae of congenital infection) requiring audiology and dental specialty care. The encounter documents long-term sequelae attributable to prior congenital infection rather than acute systemic disease, so a code from this group for late effects or sequelae is assigned to capture the chronic complication. Typical codes: A50.6, A50.7.

Related Codes

A51-EARLY-SYPHILIS

ICD-10-CM Code For Early Syphilis: Group Overview

A52-LATE-SYPHILIS

ICD-10-CM Code For Late Syphilis: Group Overview

A53-OTHER-AND-UNSPECIFIED-SYPHILIS

ICD-10-CM Code For Other And Unspecified Syphilis: Group Overview

A54-GONOCOCCAL-INFECTION

ICD-10-CM Code For Gonococcal Infection: Group Overview

A55-CHLAMYDIAL-LYMPHOGRANULOMA-VENEREUM

ICD-10-CM Code For Chlamydial Lymphogranuloma (Venereum): Group Overview

A56-OTHER-SEXUALLY-TRANSMITTED-CHLAMYDIAL-DISEASES

ICD-10-CM Code For Other Sexually Transmitted Chlamydial Diseases: Group Overview

A57-CHANCROID

ICD-10-CM Code For Chancroid: Group Overview

A58-GRANULOMA-INGUINALE

ICD-10-CM Code For Granuloma Inguinale: Group Overview

A59-TRICHOMONIASIS

ICD-10-CM Code For Trichomoniasis: Group Overview

A60-ANOGENITAL-HERPESVIRAL-INFECTIONS

ICD-10-CM Code For Anogenital Herpesviral Infections: Group Overview

Showing 1–10 of 12

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Congenital Syphilis: Group Overview

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ICD-10-CM A50: Congenital Syphilis Overview

ICD-10-CM Code For Congenital Syphilis: Group Overview

Sign up for ICD-10-CM Code For Congenital Syphilis: Group Overview policy alerts

ICD-10-CM A50: Congenital Syphilis Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-CM code group covers congenital syphilis and its manifestations?

How are early symptomatic presentations of congenital syphilis coded within this group?

Which codes document late congenital sequelae of syphilis?

Are there codes for latent and unspecified congenital syphilis in the `A50` group?

Which DRGs are related to congenital syphilis coding and reimbursement?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-CM code group covers congenital syphilis and its manifestations?

How are early symptomatic presentations of congenital syphilis coded within this group?

Which codes document late congenital sequelae of syphilis?

Are there codes for latent and unspecified congenital syphilis in the `A50` group?

Which DRGs are related to congenital syphilis coding and reimbursement?

References