Loading...

    Explore
    • Policy Monitoring
    • Live Policy Feed
    • Billing Codes
    • NPI Medicare & Medicaid
    • Healthcare Providers
    • Health Insurance Payers
    • States
    • Service Lines
    • Taxonomy Codes
    Lookup tools
    • Billing Code Lookup
    • CPT Modifier Lookup
    • Provider Taxonomy Code Lookup
    • Healthcare Provider & Facility Lookup
    • Health Insurance Payer Lookup
    • Payer Contact Directory

    Policy & Benchmark Tools

    • Prior Authorization Lookup
    • Coverage Criteria Lookup
    • Timely Filing Lookup
    • Billing Code Reimbursement Rates
    • Payer Comparison Dashboard
    • Facility Comparison Dashboard
    • All tools

    Company

    • About OpenPayer
    • Data Sources
    • Trek Health
    OpenPayerby Trek Health
    LinkedInYouTube

    © 2026 Trek Health. All rights reserved.

    OpenPayer is built and maintained by Trek Health.

    v1.0.28
    OpenPayerBilling CodesInfections with a predominantly sexual mode of transmissionICD-10-CM a53-other-and-unspecified-syphilis
    Ask Trek AI about this page

    ICD-10-CM Code For Other And Unspecified Syphilis: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group A53 includes diagnoses for other and unspecified forms of syphilis, covering nonprimary, nonsecondary, and tertiary manifestations as well as latent or unspecified presentations. These ICD-10-CM diagnosis codes are used to document clinical scenarios ranging from neurovascular and cardiac involvement to latent infections without specific signs, capturing disease stage and organ system complications relevant to this group. Accurate coding within the ICD-10-CM A53 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

    Customize your policy alerts

    Sign up for ICD-10-CM Code For Other And Unspecified Syphilis: Group Overview policy alerts

    Get alerted when relevant policies change without checking for updates manually.

    Monitor payer policy activity

    Receive email alerts as soon as relevant payer policies are published or updated.

    ICD-10-CM A53: Other And Unspecified Syphilis Overview

    The ICD-10-CM A53 code group captures infections caused by Treponema pallidum that are classified as other or unspecified forms of syphilis, affecting multiple organ systems depending on stage. These diagnoses target sexually transmitted systemic infection and may involve skin, mucous membranes, neurologic, cardiovascular, or ocular manifestations. Accurate coding matters for reimbursement because it ensures the clinical severity and organ involvement are documented for claim processing and longitudinal care tracking.

    Table of contents

    Progress1 / 6

    Explore openpayer tools

    • Billing CodesCPT, HCPCS, DRG & more
    • Reimbursement RatesCommercial vs. Medicare rate reports
    • ProvidersHospitals & facilities
    • PayersPlans & market footprint
    • Taxonomy CodesNUCC specialty codes
    • ModifiersCPT modifiers & usage
    • Prior AuthorizationPA policies by payer & drug
    • Timely FilingFiling deadlines by payer
    • Coverage CriteriaMedical necessity by payer
    • Payer ContactsClaims, PA & appeals contacts
    View all tools

    When to Use

    Use a code from this group when clinical documentation indicates syphilis that is categorized as other, late, or unspecified in stage or when organ system complications are present but do not fit primary or secondary syphilis codes. Select the code that best reflects documented stage, organ involvement, or unspecified status to support accurate classification.

    ICD-10-CM Codes

    2 rows

    ICD-10-CM CodeDescription
    A53.0Latent syphilis, unspecified as early or late
    A53.9Syphilis, unspecified

    DRG Codes

    3 rows

    DRG CodeDescription
    867Other Infectious and Parasitic Diseases Diagnoses with MCC
    868Other Infectious and Parasitic Diseases Diagnoses with CC
    869Other Infectious and Parasitic Diseases Diagnoses without CC/MCC

    Typical Clinical Scenarios

    • A sexually active adult presents to the emergency department with a new painless genital ulcer and non-tender inguinal lymphadenopathy after a recent high-risk exposure; dark-field microscopy or serology confirms primary syphilis, prompting initiation of treatment and documentation of the diagnosis. Typical codes: A53.0
    • A pregnant woman in routine prenatal screening has positive treponemal and non-treponemal serologies without current lesions and reports no prior treatment; the clinician documents an active but otherwise unspecified stage of syphilis to ensure appropriate management and pregnancy follow-up. Typical codes: A53.9
    • An adult with HIV infection is seen in outpatient follow-up for persistent positive syphilis serology without clinical signs and unclear prior treatment history; the provider records an unspecified syphilis diagnosis while arranging repeat titers and possible retreatment decisions. Typical codes: A53.9

    Related Codes

    A50-CONGENITAL-SYPHILIS

    ICD-10-CM Code For Congenital Syphilis: Group Overview

    A51-EARLY-SYPHILIS

    ICD-10-CM Code For Early Syphilis: Group Overview

    A52-LATE-SYPHILIS

    ICD-10-CM Code For Late Syphilis: Group Overview

    A54-GONOCOCCAL-INFECTION

    ICD-10-CM Code For Gonococcal Infection: Group Overview

    A55-CHLAMYDIAL-LYMPHOGRANULOMA-VENEREUM

    ICD-10-CM Code For Chlamydial Lymphogranuloma (Venereum): Group Overview

    A56-OTHER-SEXUALLY-TRANSMITTED-CHLAMYDIAL-DISEASES

    ICD-10-CM Code For Other Sexually Transmitted Chlamydial Diseases: Group Overview

    A57-CHANCROID

    ICD-10-CM Code For Chancroid: Group Overview

    A58-GRANULOMA-INGUINALE

    ICD-10-CM Code For Granuloma Inguinale: Group Overview

    A59-TRICHOMONIASIS

    ICD-10-CM Code For Trichomoniasis: Group Overview

    A60-ANOGENITAL-HERPESVIRAL-INFECTIONS

    ICD-10-CM Code For Anogenital Herpesviral Infections: Group Overview

    Showing 1–10 of 12

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
    Published by

    Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

    Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.