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    v1.0.28
    OpenPayerBilling CodesSystemic connective tissue disordersICD-10-CM m35-other-systemic-involvement-of-connective-tissue
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    ICD-10-CM Code For Other Systemic Involvement Of Connective Tissue: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group M35 includes systemic connective tissue disorders with multisystem involvement, such as systemic autoimmune conditions affecting serous membranes, vasculature, and other organ systems beyond localized connective tissue disease. These ICD-10-CM diagnosis codes are used to document clinical presentations that capture organ system involvement, disease severity, and systemic inflammatory activity relevant to this group. Accurate coding within the ICD-10-CM M35 group supports proper claim adjudication and complete clinical documentation for appropriate reimbursement.

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    ICD-10-CM M35: Other Systemic Involvement Of Connective Tissue Overview

    The ICD-10-CM M35 group represents systemic connective tissue disorders with manifestations beyond localized musculoskeletal disease, often affecting multiple organ systems such as skin, vasculature, lungs, and serous membranes. These diagnoses reflect autoimmune or inflammatory processes involving connective tissues and can indicate varying degrees of systemic involvement and severity. Accurate coding supports correct claim processing and aligns clinical documentation with reimbursement policies.

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    When to Use

    Use a code from this group when clinical documentation indicates systemic involvement of connective tissue with specific organ system manifestations or inflammatory serologic findings. Assign these codes to reflect multisystem disease activity, complications, or documented diagnoses that are distinct from localized connective tissue conditions.

    ICD-10-CM Codes

    23 rows

    ICD-10-CM CodeDescription
    M35.00Sjogren syndrome, unspecified
    M35.01Sjogren syndrome with keratoconjunctivitis
    M35.02Sjogren syndrome with lung involvement
    M35.03Sjogren syndrome with myopathy
    M35.04Sjogren syndrome with tubulo-interstitial nephropathy
    M35.05Sjogren syndrome with inflammatory arthritis
    M35.06Sjogren syndrome with peripheral nervous system involvement
    M35.07Sjogren syndrome with central nervous system involvement
    M35.08Sjogren syndrome with gastrointestinal involvement
    M35.09Sjogren syndrome with other organ involvement
    M35.0ASjogren syndrome with glomerular disease
    M35.0BSjogren syndrome with vasculitis
    M35.0CSjogren syndrome with dental involvement
    M35.1Other overlap syndromes
    M35.2Behcet's disease
    M35.3Polymyalgia rheumatica
    M35.4Diffuse (eosinophilic) fasciitis
    M35.5Multifocal fibrosclerosis
    M35.6Relapsing panniculitis [Weber-Christian]
    M35.7Hypermobility syndrome

    Showing 1–20 of 23

    DRG Codes

    7 rows

    DRG CodeDescription
    545Connective Tissue Disorders with MCC
    546Connective Tissue Disorders with CC
    547Connective Tissue Disorders without CC/MCC
    557Tendonitis, Myositis and Bursitis with MCC
    558Tendonitis, Myositis and Bursitis without MCC
    606Minor Skin Disorders with MCC
    607Minor Skin Disorders without MCC

    Typical Clinical Scenarios

    • An older patient with known systemic lupus erythematosus (SLE) presents with progressive proximal muscle weakness, elevated creatine kinase, and new dysphagia. The clinician evaluates for inflammatory myopathy as a systemic complication of the connective tissue disease and documents the specific organ involvement after laboratory and possible biopsy correlation, leading to assignment of a code denoting myositis related to systemic connective tissue disorder. Typical codes: M35.1, M35.2
    • A middle-aged patient with long-standing Sjögren syndrome arrives to clinic complaining of persistent pulmonary symptoms and new shortness of breath; imaging demonstrates interstitial lung disease and pulmonary fibrosis attributed to the underlying systemic disorder. The visit focuses on the connective tissue disease causing pulmonary involvement, and the coder selects a code reflecting other specified systemic involvement of connective tissue affecting the lungs. Typical codes: M35.81, M35.89
    • A young adult with a recent diagnosis of systemic sclerosis is admitted for acute renal crisis with malignant hypertension and rapidly rising creatinine; the team documents renal crisis as a complication of the systemic connective tissue disease. Because this is a severe organ-specific complication of the underlying disorder, an appropriate code indicating specific systemic involvement is assigned for inpatient diagnosis coding. Typical codes: M35.00, M35.09

    Related Codes

    M30-POLYARTERITIS-NODOSA-AND-RELATED-CONDITIONS

    ICD-10-CM Code For Polyarteritis Nodosa And Related Conditions: Group Overview

    M31-OTHER-NECROTIZING-VASCULOPATHIES

    ICD-10-CM Code For Other Necrotizing Vasculopathies: Group Overview

    M32-SYSTEMIC-LUPUS-ERYTHEMATOSUS

    ICD-10-CM Code For Systemic Lupus Erythematosus SLE: Group Overview

    M33-DERMATOPOLYMYOSITIS-CONDITIONS

    ICD-10-CM Code For Dermatopolymyositis: Group Overview

    M34-SYSTEMIC-SCLEROSIS-SCLERODERMA

    ICD-10-CM Code For Systemic Sclerosis [Scleroderma]: Group Overview

    M36-SYSTEMIC-CONNECTIVE-TISSUE-DISORDERS

    ICD-10-CM Code For Systemic Disorders Of Connective Tissue In Diseases Classified Elsewhere: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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