HCPCS Level II J7324: Hyaluronan (Orthovisc) Intra-articular Injection

HCPCS Level II code J7324 describes a per-dose product formulation of hyaluronan or derivative (Orthovisc) used for intra-articular injection to manage joint pain, commonly delivered as an intra-articular viscosupplementation injection in an outpatient clinic or ambulatory procedure setting; this code is used to report the drug product per dose for billing and medical record purposes.

For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Antibody-Drug Conjugates, Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only).

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HCPCS Level II J7324: Hyaluronan (Orthovisc) Intra-articular Injection

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Get alerted when payer policies referencing J7324 are released or updated.

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Clinical & Coding Specifications

Clinical Context

A 64-year-old patient with symptomatic osteoarthritis of the knee presents to an orthopedic clinic after months of conservative management including physical therapy, oral NSAIDs, and activity modification with persistent pain and functional limitation. The clinician documents localized knee joint pain, stiffness, and reduced range of motion consistent with degenerative joint disease. After shared decision-making, a plan is made to perform an intra-articular viscosupplementation injection using J7324 (Hyaluronan or derivative, ORTHOVISC, per dose). The procedure is performed in an outpatient clinic procedure room or ambulatory surgery center: the patient is positioned supine, the knee is prepped with antiseptic, local anesthetic is administered to the skin and subcutaneous tissues, and a single intra-articular injection of the hyaluronan product is delivered using aseptic technique under anatomic landmark guidance or ultrasound as documented. Post‑procedure instructions, observation for immediate adverse reaction, and activity guidance are provided prior to discharge. The encounter documentation includes indication (osteoarthritis of the knee), informed consent, laterality (RT/LT), product name and dose, administration route, lot number if required, and any immediate complications.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`20610`	Arthrocentesis, aspiration and/or injection; major joint or bursa (e.g., shoulder, hip, knee)	Primary procedural code for the intra-articular injection technique used to administer `J7324`
`67028`	Intravitreal injection of a pharmacologic agent (for contrast — not related)	Data not applicable — this CPT is unrelated to knee injections
`76942`	Ultrasound guidance for needle placement, imaging supervision and interpretation	Used when ultrasound guidance is employed for accurate intra-articular placement prior to administering `J7324`
`99070`	Supplies and materials (exceptions) used for procedures, non-covered items or devices	May be billed when specific supplies for the injection are separately billable per payer policies
`99000`	Handling and/or conveyance of specimens for transfer from the office to a laboratory (not typically used)	Generally not used for viscosupplementation but listed when synovial fluid removal and lab handling occur

Note: If a specific CPT code is required by the payer for needle placement or imaging guidance, documentation must support use of the selected CPT code in conjunction with J7324.

Related Modifiers

5 rows

Modifier	Description	When to Use
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
76	Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…	- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
77	Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…	- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
363LF0000X	Family Nurse Practitioner	Physician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
207P00000X	Emergency Medicine Physician	An emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
1041S0200X	School Social Worker	Behavioral Health & Social Service Providers · Social Worker
364SE1400X	Ethics Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
364SP1700X	Perinatal Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist

Related ICD-10-CM Codes

11 rows

ICD-10-CM Code	Description
M17.0	Bilateral primary osteoarthritis of knee
M17.10	Unilateral primary osteoarthritis, unspecified knee
M17.11	Unilateral primary osteoarthritis, right knee
M17.12	Unilateral primary osteoarthritis, left knee
M17.2	Bilateral post-traumatic osteoarthritis of knee
M17.4	Other bilateral secondary osteoarthritis of knee
M17.5	Other unilateral secondary osteoarthritis of knee
M17.9	Osteoarthritis of knee, unspecified
M25.561	Pain in right knee
M25.562	Pain in left knee

Showing 1–10 of 11

Related Payer Policy Updates

Specialty: Hematology/Oncology1 / 3

10 rows

Policy	Payer	Effective Date
Epithelial Cell Cytology in Breast Cancer Risk Assessment	Oscar Health	2026-10-01
Antibody-Drug Conjugates	Premera Bluecross	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)	UnitedHealthcare	2026-08-01
Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)	UnitedHealthcare	2026-08-01
Chimeric Antigen Receptor (CAR) T-Cell Therapy	Colorado Rocky Mountain Health Plans	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)	UnitedHealthcare	2026-08-01
Allogeneic Hematopoietic Progenitor Cell Therapy	Ambetter Georgia	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)	UnitedHealthcare	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)	UnitedHealthcare	2026-08-01
Reblozyl (luspatercept-aamt) Medical Benefit Drug Policy	UnitedHealthcare	2026-08-01

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`20610`	Arthrocentesis, aspiration and/or injection; major joint or bursa (e.g., shoulder, hip, knee)	Primary procedural code for the intra-articular injection technique used to administer `J7324`
`67028`	Intravitreal injection of a pharmacologic agent (for contrast — not related)	Data not applicable — this CPT is unrelated to knee injections
`76942`	Ultrasound guidance for needle placement, imaging supervision and interpretation	Used when ultrasound guidance is employed for accurate intra-articular placement prior to administering `J7324`
`99070`	Supplies and materials (exceptions) used for procedures, non-covered items or devices	May be billed when specific supplies for the injection are separately billable per payer policies
`99000`	Handling and/or conveyance of specimens for transfer from the office to a laboratory (not typically used)	Generally not used for viscosupplementation but listed when synovial fluid removal and lab handling occur

Note: If a specific CPT code is required by the payer for needle placement or imaging guidance, documentation must support use of the selected CPT code in conjunction with J7324.

Related Modifiers

5 rows

Modifier	Description	When to Use
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
76	Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…	- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
77	Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…	- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
208000000X	Pediatrics Physician	A pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
363LF0000X	Family Nurse Practitioner	Physician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
207P00000X	Emergency Medicine Physician	An emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
1041S0200X	School Social Worker	Behavioral Health & Social Service Providers · Social Worker
364SE1400X	Ethics Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
364SP1700X	Perinatal Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist

Related ICD-10-CM Codes

11 rows

ICD-10-CM Code	Description
M17.0	Bilateral primary osteoarthritis of knee
M17.10	Unilateral primary osteoarthritis, unspecified knee
M17.11	Unilateral primary osteoarthritis, right knee
M17.12	Unilateral primary osteoarthritis, left knee
M17.2	Bilateral post-traumatic osteoarthritis of knee
M17.4	Other bilateral secondary osteoarthritis of knee
M17.5	Other unilateral secondary osteoarthritis of knee
M17.9	Osteoarthritis of knee, unspecified
M25.561	Pain in right knee
M25.562	Pain in left knee

Showing 1–10 of 11

Related Payer Policy Updates

Specialty: Hematology/Oncology1 / 3

10 rows

Policy	Payer	Effective Date
Epithelial Cell Cytology in Breast Cancer Risk Assessment	Oscar Health	2026-10-01
Antibody-Drug Conjugates	Premera Bluecross	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)	UnitedHealthcare	2026-08-01
Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)	UnitedHealthcare	2026-08-01
Chimeric Antigen Receptor (CAR) T-Cell Therapy	Colorado Rocky Mountain Health Plans	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)	UnitedHealthcare	2026-08-01
Allogeneic Hematopoietic Progenitor Cell Therapy	Ambetter Georgia	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)	UnitedHealthcare	2026-08-01
Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)	UnitedHealthcare	2026-08-01
Reblozyl (luspatercept-aamt) Medical Benefit Drug Policy	UnitedHealthcare	2026-08-01

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS Level II J7324: Hyaluronan (Orthovisc) Intra-articular Injection

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HCPCS Level II J7324: Hyaluronan (Orthovisc) Intra-articular Injection

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Payer Policy Updates

Related Codes

What does HCPCS code J7324 represent and where is it typically administered?

Which CPT codes are commonly billed with J7324 and when are they appropriate to use?

What modifiers are commonly used with J7324 and what do they indicate?

Which diagnoses commonly support medical necessity for billing J7324 and what documentation is emphasized?

Which payers are referenced for J7324 coverage and what payer‑specific considerations are mentioned?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Payer Policy Updates

Related Codes

What does HCPCS code J7324 represent and where is it typically administered?

Which CPT codes are commonly billed with J7324 and when are they appropriate to use?

What modifiers are commonly used with J7324 and what do they indicate?

Which diagnoses commonly support medical necessity for billing J7324 and what documentation is emphasized?

Which payers are referenced for J7324 coverage and what payer‑specific considerations are mentioned?

References