ICD-10-CM Code For Other Demyelinating Diseases Of Central Nervous System: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group G37 includes demyelinating diseases of the central nervous system that are not classified elsewhere, such as acute disseminated encephalomyelitis and other specified demyelinating disorders affecting the brain, spinal cord, or optic nerves. These ICD-10-CM diagnosis codes are used to document clinical presentations of central nervous system demyelination, capturing disease distribution, severity, and any associated neurologic deficits. Accurate coding within the ICD-10-CM G37 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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ICD-10-CM G37: Other Demyelinating Diseases Of Central Nervous System Overview

This group includes demyelinating conditions affecting the central nervous system beyond multiple sclerosis and related disorders, targeting the brain, spinal cord, and optic pathways. Accurate coding captures the specific demyelinating diagnosis, anatomical involvement, and disease complexity, which informs clinical records and supports appropriate reimbursement. Clear documentation of neurologic signs, imaging, and course is important for correct code selection.

When to Use

Use a code from this group when clinical documentation indicates a demyelinating disease of the central nervous system that does not meet criteria for multiple sclerosis or other specified categories. Select the most specific code based on documented diagnosis, anatomical involvement, and clinical course.

ICD-10-CM Codes

9 rows

ICD-10-CM Code	Description
G37.0	Diffuse sclerosis of central nervous system
G37.1	Central demyelination of corpus callosum
G37.2	Central pontine myelinolysis
G37.3	Acute transverse myelitis in demyelinating disease of central nervous system
G37.4	Subacute necrotizing myelitis of central nervous system
G37.5	Concentric sclerosis [Balo] of central nervous system
G37.81	Myelin oligodendrocyte glycoprotein antibody disease
G37.89	Other specified demyelinating diseases of central nervous system
G37.9	Demyelinating disease of central nervous system, unspecified

DRG Codes

11 rows

DRG Code	Description
023	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis with MCC or Antineoplastic Implant or Epilepsy with Neurostimulator
024	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis without MCC
058	Multiple Sclerosis and Cerebellar Ataxia with MCC
059	Multiple Sclerosis and Cerebellar Ataxia with CC
060	Multiple Sclerosis and Cerebellar Ataxia without CC/MCC
097	Non-Bacterial Infection of Nervous System Except Viral Meningitis with MCC
098	Non-Bacterial Infection of Nervous System Except Viral Meningitis with CC
099	Non-Bacterial Infection of Nervous System Except Viral Meningitis without CC/MCC
974	HIV with Major Related Condition with MCC
975	HIV with Major Related Condition with CC
976	HIV with Major Related Condition without CC/MCC

Typical Clinical Scenarios

A middle-aged adult presents to the emergency department with acute onset of unilateral optic neuritis characterized by painful eye movement and subacute vision loss over several days. Neuro-ophthalmologic exam shows decreased visual acuity and a relative afferent pupillary defect; MRI brain and orbit reveal an enhancing optic nerve lesion without widespread brain plaques, prompting a diagnosis within this demyelinating group for isolated optic nerve inflammation. Typical codes: G37.0
A young adult with relapsing-remitting neurological symptoms (intermittent paresthesias, motor weakness, and balance problems) undergoing outpatient neurology follow-up for a chronic demyelinating disorder that does not meet full criteria for multiple sclerosis; clinical course and imaging indicate a chronic central nervous system demyelinating disease requiring long-term management. Typical codes: G37.2, G37.81
An older patient hospitalized for acute new focal neurological deficits after a recent viral illness, where evaluation shows progressive central demyelination attributed to an inflammatory myelopathy rather than ischemic stroke; inpatient workup excludes other causes and a demyelinating diagnosis is recorded as the reason for admission and treatment. Typical codes: G37.3, G37.89

Related Codes

G35-MULTIPLE-SCLEROSIS

ICD-10-CM Code For Multiple Sclerosis: Group Overview

G36-OTHER-ACUTE-DISSEMINATED-DEMYELINATION

ICD-10-CM Code For Other Acute Disseminated Demyelination: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-CM Codes

9 rows

ICD-10-CM Code	Description
G37.0	Diffuse sclerosis of central nervous system
G37.1	Central demyelination of corpus callosum
G37.2	Central pontine myelinolysis
G37.3	Acute transverse myelitis in demyelinating disease of central nervous system
G37.4	Subacute necrotizing myelitis of central nervous system
G37.5	Concentric sclerosis [Balo] of central nervous system
G37.81	Myelin oligodendrocyte glycoprotein antibody disease
G37.89	Other specified demyelinating diseases of central nervous system
G37.9	Demyelinating disease of central nervous system, unspecified

DRG Codes

11 rows

DRG Code	Description
023	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis with MCC or Antineoplastic Implant or Epilepsy with Neurostimulator
024	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis without MCC
058	Multiple Sclerosis and Cerebellar Ataxia with MCC
059	Multiple Sclerosis and Cerebellar Ataxia with CC
060	Multiple Sclerosis and Cerebellar Ataxia without CC/MCC
097	Non-Bacterial Infection of Nervous System Except Viral Meningitis with MCC
098	Non-Bacterial Infection of Nervous System Except Viral Meningitis with CC
099	Non-Bacterial Infection of Nervous System Except Viral Meningitis without CC/MCC
974	HIV with Major Related Condition with MCC
975	HIV with Major Related Condition with CC
976	HIV with Major Related Condition without CC/MCC

Typical Clinical Scenarios

A middle-aged adult presents to the emergency department with acute onset of unilateral optic neuritis characterized by painful eye movement and subacute vision loss over several days. Neuro-ophthalmologic exam shows decreased visual acuity and a relative afferent pupillary defect; MRI brain and orbit reveal an enhancing optic nerve lesion without widespread brain plaques, prompting a diagnosis within this demyelinating group for isolated optic nerve inflammation. Typical codes: G37.0
A young adult with relapsing-remitting neurological symptoms (intermittent paresthesias, motor weakness, and balance problems) undergoing outpatient neurology follow-up for a chronic demyelinating disorder that does not meet full criteria for multiple sclerosis; clinical course and imaging indicate a chronic central nervous system demyelinating disease requiring long-term management. Typical codes: G37.2, G37.81
An older patient hospitalized for acute new focal neurological deficits after a recent viral illness, where evaluation shows progressive central demyelination attributed to an inflammatory myelopathy rather than ischemic stroke; inpatient workup excludes other causes and a demyelinating diagnosis is recorded as the reason for admission and treatment. Typical codes: G37.3, G37.89

Related Codes

G35-MULTIPLE-SCLEROSIS

ICD-10-CM Code For Multiple Sclerosis: Group Overview

G36-OTHER-ACUTE-DISSEMINATED-DEMYELINATION

ICD-10-CM Code For Other Acute Disseminated Demyelination: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Other Demyelinating Diseases Of Central Nervous System: Group Overview

Sign up for ICD-10-CM Code For Other Demyelinating Diseases Of Central Nervous System: Group Overview policy alerts

ICD-10-CM G37: Other Demyelinating Diseases Of Central Nervous System Overview

ICD-10-CM Code For Other Demyelinating Diseases Of Central Nervous System: Group Overview

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ICD-10-CM G37: Other Demyelinating Diseases Of Central Nervous System Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-CM codes are included in the G37 group?

How does accurate documentation affect coding and reimbursement for G37 diagnoses?

Which specific G37 code denotes myelin oligodendrocyte glycoprotein antibody disease?

What related DRGs might be relevant when a G37 diagnosis appears on a claim?

Which G37 code should be used when the demyelinating disease of the central nervous system is unspecified?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-CM codes are included in the G37 group?

How does accurate documentation affect coding and reimbursement for G37 diagnoses?

Which specific G37 code denotes myelin oligodendrocyte glycoprotein antibody disease?

What related DRGs might be relevant when a G37 diagnosis appears on a claim?

Which G37 code should be used when the demyelinating disease of the central nervous system is unspecified?

References