ICD-10-CM Code For Multiple Sclerosis: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group G35 includes multiple sclerosis, a chronic demyelinating disease of the central nervous system that encompasses relapsing and progressive forms and manifestations affecting the brain, spinal cord, and optic nerves. These ICD-10-CM diagnosis codes are used to document neurologic dysfunctions such as vision loss, motor weakness, sensory disturbances, and impaired coordination, capturing disease severity and organ system involvement. Accurate coding within the ICD-10-CM G35 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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ICD-10-CM G35: Multiple Sclerosis Overview

The ICD-10-CM G35 group represents multiple sclerosis and related demyelinating conditions of the central nervous system, characterized by immune-mediated damage to myelin. These diagnoses target the brain, spinal cord, and optic nerves and often present with varied neurologic deficits. Accurate coding matters for correct clinical records and appropriate reimbursement because it reflects disease severity and resource use.

When to Use

Use a code from this group when a clinician documents a diagnosis of multiple sclerosis or its specific clinical subtype. Codes from this group are used to capture episodes of neurologic relapse, disease progression, and related neurologic complications.

ICD-10-CM Codes

8 rows

ICD-10-CM Code	Description
G35.A	Relapsing-remitting multiple sclerosis
G35.B0	Primary progressive multiple sclerosis, unspecified
G35.B1	Active primary progressive multiple sclerosis
G35.B2	Non-active primary progressive multiple sclerosis
G35.C0	Secondary progressive multiple sclerosis, unspecified
G35.C1	Active secondary progressive multiple sclerosis
G35.C2	Non-active secondary progressive multiple sclerosis
G35.D	Multiple sclerosis, unspecified

DRG Codes

3 rows

DRG Code	Description
058	Multiple Sclerosis and Cerebellar Ataxia with MCC
059	Multiple Sclerosis and Cerebellar Ataxia with CC
060	Multiple Sclerosis and Cerebellar Ataxia without CC/MCC

Typical Clinical Scenarios

A 28-year-old woman with a 6-year history of relapsing-remitting neurological symptoms presents with new-onset unilateral optic neuritis and worsening leg weakness over several days; neurologic exam shows an afferent pupillary defect and increased spasticity, and MRI shows new enhancing white matter lesions consistent with an acute relapse of her underlying demyelinating disease. She seeks urgent outpatient neurology evaluation for treatment of the relapse and modification of disease-modifying therapy. Typical codes: G35.B0, G35.C0
A 52-year-old man with long-standing primary progressive motor decline arrives for routine follow-up complaining of gradually worsening gait impairment, spasticity, and urinary urgency without discrete relapses; exam and prior imaging document progressive spinal cord and brain involvement over years. He is managed as a chronic, steadily progressive demyelinating disorder requiring symptomatic treatments and disability assessment. Typical codes: G35.B2, G35.C2
A 39-year-old woman with diagnosed demyelinating disease presents to the emergency department with an acute urinary tract infection and new fever; during admission she develops transient worsening of baseline neurologic deficits (increased weakness and sensory changes) attributed to an infectious exacerbation rather than new inflammatory lesions. A code from the group is assigned to indicate the underlying demyelinating condition as a comorbidity influencing care and recovery. Typical codes: G35.A, G35.D

ICD-10-CM Code For Other Acute Disseminated Demyelination: Group Overview

G37-OTHER-DEMYELINATING-DISEASES

ICD-10-CM Code For Other Demyelinating Diseases Of Central Nervous System: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-CM Codes

8 rows

ICD-10-CM Code	Description
G35.A	Relapsing-remitting multiple sclerosis
G35.B0	Primary progressive multiple sclerosis, unspecified
G35.B1	Active primary progressive multiple sclerosis
G35.B2	Non-active primary progressive multiple sclerosis
G35.C0	Secondary progressive multiple sclerosis, unspecified
G35.C1	Active secondary progressive multiple sclerosis
G35.C2	Non-active secondary progressive multiple sclerosis
G35.D	Multiple sclerosis, unspecified

DRG Codes

3 rows

DRG Code	Description
058	Multiple Sclerosis and Cerebellar Ataxia with MCC
059	Multiple Sclerosis and Cerebellar Ataxia with CC
060	Multiple Sclerosis and Cerebellar Ataxia without CC/MCC

Typical Clinical Scenarios

A 28-year-old woman with a 6-year history of relapsing-remitting neurological symptoms presents with new-onset unilateral optic neuritis and worsening leg weakness over several days; neurologic exam shows an afferent pupillary defect and increased spasticity, and MRI shows new enhancing white matter lesions consistent with an acute relapse of her underlying demyelinating disease. She seeks urgent outpatient neurology evaluation for treatment of the relapse and modification of disease-modifying therapy. Typical codes: G35.B0, G35.C0
A 52-year-old man with long-standing primary progressive motor decline arrives for routine follow-up complaining of gradually worsening gait impairment, spasticity, and urinary urgency without discrete relapses; exam and prior imaging document progressive spinal cord and brain involvement over years. He is managed as a chronic, steadily progressive demyelinating disorder requiring symptomatic treatments and disability assessment. Typical codes: G35.B2, G35.C2
A 39-year-old woman with diagnosed demyelinating disease presents to the emergency department with an acute urinary tract infection and new fever; during admission she develops transient worsening of baseline neurologic deficits (increased weakness and sensory changes) attributed to an infectious exacerbation rather than new inflammatory lesions. A code from the group is assigned to indicate the underlying demyelinating condition as a comorbidity influencing care and recovery. Typical codes: G35.A, G35.D

ICD-10-CM Code For Other Acute Disseminated Demyelination: Group Overview

G37-OTHER-DEMYELINATING-DISEASES

ICD-10-CM Code For Other Demyelinating Diseases Of Central Nervous System: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Multiple Sclerosis: Group Overview

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ICD-10-CM G35: Multiple Sclerosis Overview

ICD-10-CM Code For Multiple Sclerosis: Group Overview

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ICD-10-CM G35: Multiple Sclerosis Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-CM Code For Multiple Sclerosis: Group Overview

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ICD-10-CM G35: Multiple Sclerosis Overview

ICD-10-CM Code For Multiple Sclerosis: Group Overview

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ICD-10-CM G35: Multiple Sclerosis Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

What does the ICD-10-CM G35 group represent?

Which specific ICD-10-CM codes are listed in the G35 group?

How does coding within the G35 group affect claims and documentation?

What neurologic dysfunctions are captured by ICD-10-CM G35 codes?

Which DRGs are related to the G35 group for inpatient classification?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

What does the ICD-10-CM G35 group represent?

Which specific ICD-10-CM codes are listed in the G35 group?

How does coding within the G35 group affect claims and documentation?

What neurologic dysfunctions are captured by ICD-10-CM G35 codes?

Which DRGs are related to the G35 group for inpatient classification?

References