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    v1.0.28
    OpenPayerBilling CodesMetabolic disordersICD-10-CM e88-other-and-unspecified-metabolic-disorders
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    ICD-10-CM Code For Other And Unspecified Metabolic Disorders: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group E88 includes heterogeneous metabolic disorders not classified elsewhere, such as disorders of carbohydrate, lipid, and other intermediary metabolism and unspecified metabolic conditions. These ICD-10-CM diagnosis codes are used to document clinical presentations involving systemic biochemical dysfunction, multisystem involvement, or metabolic imbalance that require specific diagnostic or therapeutic management. Accurate coding within the ICD-10-CM E88 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM E88: Other And Unspecified Metabolic Disorders Overview

    The diagnoses in this group represent metabolic disorders that do not fit into more specific categories within the metabolic chapter, including systemic metabolic abnormalities and disorders of intermediary metabolism. These conditions primarily affect biochemical processes and may involve multiple organ systems. Accurate coding of these disorders matters for correct clinical documentation and reimbursement because it informs claim adjudication and reflects clinical complexity.

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    When to Use

    Use a code from this group when a clinician documents a metabolic disorder that does not have a more specific ICD-10-CM category or when the metabolic condition is described as unspecified or other. Select the most specific code available from the group that matches the documented clinical findings and diagnostic testing.

    ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    E88.01Alpha-1-antitrypsin deficiency
    E88.02Plasminogen deficiency
    E88.09Other disorders of plasma-protein metabolism, not elsewhere classified
    E88.10Lipodystrophy, unspecified
    E88.11Partial lipodystrophy
    E88.12Generalized lipodystrophy
    E88.13Localized lipodystrophy
    E88.14HIV-associated lipodystrophy
    E88.19Other lipodystrophy, not elsewhere classified
    E88.2Lipomatosis, not elsewhere classified
    E88.3Tumor lysis syndrome
    E88.40Mitochondrial metabolism disorder, unspecified
    E88.41MELAS syndrome
    E88.42MERRF syndrome
    E88.43Disorders of mitochondrial tRNA synthetases
    E88.49Other mitochondrial metabolism disorders
    E88.810Metabolic syndrome
    E88.811Insulin resistance syndrome, Type A
    E88.818Other insulin resistance
    E88.819Insulin resistance, unspecified

    Showing 1–20 of 24

    DRG Codes

    17 rows

    DRG CodeDescription
    642Inborn and Other Disorders of Metabolism
    673Other Kidney and Urinary Tract Procedures with MCC
    674Other Kidney and Urinary Tract Procedures with CC
    675Other Kidney and Urinary Tract Procedures without CC/MCC
    682Renal Failure with MCC
    683Renal Failure with CC
    684Renal Failure without CC/MCC
    791Prematurity with Major Problems
    793Full Term Neonate with Major Problems
    826Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with MCC
    827Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with CC
    828Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures without CC/MCC
    829Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures with CC/MCC
    830Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures without CC/MCC
    843Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with MCC
    844Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with CC
    845Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses without CC/MCC

    Typical Clinical Scenarios

    • An adult presents to the emergency department with acute onset severe muscle weakness, hyporeflexia, and cardiac arrhythmia after several days of profuse vomiting and diarrhea leading to significant electrolyte disturbances; workup reveals life‑threatening hypokalemia secondary to an acquired metabolic disorder and no primary renal tubular defect. A diagnosis from this group is used to capture the acute electrolyte/metabolic disturbance as the primary metabolic disorder complicating the presentation. Typical codes: E88.810, E88.819
    • A middle‑aged patient is seen in endocrinology clinic for persistent, unexplained hypertriglyceridemia and hepatomegaly despite lifestyle measures; genetic testing and metabolic evaluation suggest a primary lipid metabolism disorder not classified elsewhere causing chronic hyperlipidemia and related symptoms. A code from this group is assigned to document the chronic, inherited or idiopathic metabolic lipid disorder driving ongoing management. Typical codes: E88.2, E88.1
    • An elderly patient admitted for evaluation of progressive cognitive decline and peripheral neuropathy is found to have abnormal accumulation of a lysosomal substrate on enzymatic assay consistent with a late‑onset storage disorder presenting as a comorbidity that complicates dementia care and rehabilitation. A code in this group is used to record the underlying metabolic storage condition as a significant comorbidity affecting treatment and prognosis. Typical codes: E88.49, E88.9

    Related Codes

    E70-DISORDERS-OF-AROMATIC-AMINO-ACID-METABOLISM

    ICD-10-CM Code For Disorders Of Aromatic Amino-Acid Metabolism: Group Overview

    E71-DISORDERS-OF-BRANCHED-CHAIN-AMINO-ACID-METABOLISM

    ICD-10-CM Code For Disorders Of Branched Chain Amino Acid Metabolism And Fatty Acid Metabolism: Group Overview

    E72-OTHER-DISORDERS-OF-AMINO-ACID-METABOLISM

    ICD-10-CM Code For Other Disorders Of Amino-Acid Metabolism: Group Overview

    E73-LACTOSE-INTOLERANCE

    ICD-10-CM Code For Lactose Intolerance: Group Overview

    E74-OTHER-DISORDERS-OF-CARBOHYDRATE-METABOLISM

    ICD-10-CM Code For Other Disorders Of Carbohydrate Metabolism: Group Overview

    E75-DISORDERS-OF-SPHINGOLIPID-METABOLISM

    ICD-10-CM Code For Disorders Of Sphingolipid Metabolism And Other Lipid Storage Disorders: Group Overview

    E76-DISORDERS-OF-GLYCOSAMINOGLYCAN-METABOLISM

    ICD-10-CM Code For Disorders Of Glycosaminoglycan Metabolism: Group Overview

    E77-DISORDERS-OF-GLYCOPROTEIN-METABOLISM

    ICD-10-CM Code For Disorders Of Glycoprotein Metabolism: Group Overview

    E78-DISORDERS-OF-LIPOPROTEIN-METABOLISM

    ICD-10-CM Code For Disorders Of Lipoprotein Metabolism And Other Lipidemias: Group Overview

    E79-DISORDERS-OF-PURINE-AND-PYRIMIDINE-METABOLISM

    ICD-10-CM Code For Disorders Of Purine And Pyrimidine Metabolism: Group Overview

    Showing 1–10 of 16

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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