ICD-10-CM Code For Other Specified Diseases With Participation Of Lymphoreticular And Reticulohistiocytic Tissue: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group D76 includes specified disorders involving lymphoreticular and reticulohistiocytic tissue such as histiocytoses and related proliferative conditions that can affect lymph nodes, skin, spleen, and other organs. These ICD-10-CM diagnosis codes are used to document clinical scenarios including localized or systemic histiocytic proliferations, disease severity, organ involvement, and diagnostic complexity relevant to this group. Accurate coding within the ICD-10-CM D76 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

Customize your policy alerts

Sign up for ICD-10-CM Code For Other Specified Diseases With Participation Of Lymphoreticular And Reticulohistiocytic Tissue: Group Overview policy alerts

Get alerted when relevant policies change without checking for updates manually.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

ICD-10-CM D76: Other Specified Diseases With Participation Of Lymphoreticular And Reticulohistiocytic Tissue Overview

This group includes uncommon disorders characterized by involvement of lymphoreticular and reticulohistiocytic tissues, such as certain histiocytic proliferations and reticulohistiocytosis. These conditions affect the immune and hematologic systems and may involve lymph nodes, spleen, skin, or other organs. Accurate coding matters for reimbursement because it ensures correct clinical documentation and supports appropriate claim processing.

Explore openpayer tools

View all tools

ICD-10-CM Code For Other Specified Diseases With Participation Of Lymphoreticular And Reticulohistiocytic Tissue: Group Overview

Customize your policy alerts

Sign up for ICD-10-CM Code For Other Specified Diseases With Participation Of Lymphoreticular And Reticulohistiocytic Tissue: Group Overview policy alerts

Get alerted when relevant policies change without checking for updates manually.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

ICD-10-CM D76: Other Specified Diseases With Participation Of Lymphoreticular And Reticulohistiocytic Tissue Overview

When to Use

Use codes from this group when clinical documentation indicates a specified histiocytic or reticulohistiocytic disorder involving lymphoreticular tissues or related organ involvement. Assign the most specific code that reflects the documented disease presentation, organ involvement, and any associated manifestations.

ICD-10-CM Codes

3 rows

ICD-10-CM Code	Description
D76.1	Hemophagocytic lymphohistiocytosis
D76.2	Hemophagocytic syndrome, infection-associated
D76.3	Other histiocytosis syndromes

DRG Codes

3 rows

DRG Code	Description
814	Reticuloendothelial and Immunity Disorders with MCC
815	Reticuloendothelial and Immunity Disorders with CC
816	Reticuloendothelial and Immunity Disorders without CC/MCC

Typical Clinical Scenarios

An adult patient presents to the emergency department with several days of high fevers, progressive fatigue, and new-onset painless cervical and axillary lymphadenopathy after a recent viral illness. Laboratory studies reveal marked hyperferritinemia, elevated liver enzymes, cytopenias, and bone marrow biopsy shows hemophagocytosis consistent with a reactive histiocytic proliferation; a diagnosis from this group is assigned to capture a systemic histiocytic disorder associated with lymphoreticular tissue involvement. Typical codes: D76.1
A child is evaluated in outpatient hematology for persistent lymphadenopathy, intermittent low-grade fevers, and weight loss over months; excisional lymph node biopsy demonstrates non-Langerhans cell histiocytosis with granulomatous inflammation localized to lymphoreticular tissue without systemic organ failure. A code from this group is used to document a chronic, localized histiocytic disorder affecting lymphoid structures managed longitudinally. Typical codes: D76.2
A hospitalized patient with known autoimmune disease develops sudden multi-organ dysfunction with fever and pancytopenia; bone marrow examination identifies widespread histiocytic proliferation with reticulohistiocytic infiltration contributing to the clinical decompensation. A code from this group is assigned as a secondary diagnosis to denote the histiocytic disorder complicating the primary illness and driving the acute presentation. Typical codes: D76.3

Related Codes

D70-NEUTROPENIA

ICD-10-CM Code For Neutropenia: Group Overview

D71-FUNCTIONAL-DISORDERS-OF-POLYMORPHONUCLEAR-NEUTROPHILS

ICD-10-CM Code For Functional Disorders Of Polymorphonuclear Neutrophils: Group Overview

D72-OTHER-DISORDERS-OF-WHITE-BLOOD-CELLS

ICD-10-CM Code For Other Disorders Of White Blood Cells: Group Overview

D73-DISEASES-OF-SPLEEN

ICD-10-CM Code For Diseases Of Spleen: Group Overview

D74-METHEMOGLOBINEMIA

ICD-10-CM Code For Methemoglobinemia: Group Overview

D75-OTHER-AND-UNSPECIFIED-BLOOD-DISORDERS

ICD-10-CM Code For Other And Unspecified Diseases Of Blood And Blood-Forming Organs: Group Overview

D77-OTHER-DISORDERS-OF-BLOOD

ICD-10-CM Code For Other Disorders Of Blood And Blood-Forming Organs In Diseases Classified Elsewhere: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

When to Use

ICD-10-CM Codes

3 rows

ICD-10-CM Code	Description
D76.1	Hemophagocytic lymphohistiocytosis
D76.2	Hemophagocytic syndrome, infection-associated
D76.3	Other histiocytosis syndromes

DRG Codes

3 rows

DRG Code	Description
814	Reticuloendothelial and Immunity Disorders with MCC
815	Reticuloendothelial and Immunity Disorders with CC
816	Reticuloendothelial and Immunity Disorders without CC/MCC

Typical Clinical Scenarios

An adult patient presents to the emergency department with several days of high fevers, progressive fatigue, and new-onset painless cervical and axillary lymphadenopathy after a recent viral illness. Laboratory studies reveal marked hyperferritinemia, elevated liver enzymes, cytopenias, and bone marrow biopsy shows hemophagocytosis consistent with a reactive histiocytic proliferation; a diagnosis from this group is assigned to capture a systemic histiocytic disorder associated with lymphoreticular tissue involvement. Typical codes: D76.1
A child is evaluated in outpatient hematology for persistent lymphadenopathy, intermittent low-grade fevers, and weight loss over months; excisional lymph node biopsy demonstrates non-Langerhans cell histiocytosis with granulomatous inflammation localized to lymphoreticular tissue without systemic organ failure. A code from this group is used to document a chronic, localized histiocytic disorder affecting lymphoid structures managed longitudinally. Typical codes: D76.2
A hospitalized patient with known autoimmune disease develops sudden multi-organ dysfunction with fever and pancytopenia; bone marrow examination identifies widespread histiocytic proliferation with reticulohistiocytic infiltration contributing to the clinical decompensation. A code from this group is assigned as a secondary diagnosis to denote the histiocytic disorder complicating the primary illness and driving the acute presentation. Typical codes: D76.3

Related Codes

D70-NEUTROPENIA

ICD-10-CM Code For Neutropenia: Group Overview

D71-FUNCTIONAL-DISORDERS-OF-POLYMORPHONUCLEAR-NEUTROPHILS

ICD-10-CM Code For Functional Disorders Of Polymorphonuclear Neutrophils: Group Overview

D72-OTHER-DISORDERS-OF-WHITE-BLOOD-CELLS

ICD-10-CM Code For Other Disorders Of White Blood Cells: Group Overview

D73-DISEASES-OF-SPLEEN

ICD-10-CM Code For Diseases Of Spleen: Group Overview

D74-METHEMOGLOBINEMIA

ICD-10-CM Code For Methemoglobinemia: Group Overview

D75-OTHER-AND-UNSPECIFIED-BLOOD-DISORDERS

ICD-10-CM Code For Other And Unspecified Diseases Of Blood And Blood-Forming Organs: Group Overview

D77-OTHER-DISORDERS-OF-BLOOD

ICD-10-CM Code For Other Disorders Of Blood And Blood-Forming Organs In Diseases Classified Elsewhere: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Other Specified Diseases With Participation Of Lymphoreticular And Reticulohistiocytic Tissue: Group Overview

Sign up for ICD-10-CM Code For Other Specified Diseases With Participation Of Lymphoreticular And Reticulohistiocytic Tissue: Group Overview policy alerts

ICD-10-CM D76: Other Specified Diseases With Participation Of Lymphoreticular And Reticulohistiocytic Tissue Overview

ICD-10-CM Code For Other Specified Diseases With Participation Of Lymphoreticular And Reticulohistiocytic Tissue: Group Overview

Sign up for ICD-10-CM Code For Other Specified Diseases With Participation Of Lymphoreticular And Reticulohistiocytic Tissue: Group Overview policy alerts

ICD-10-CM D76: Other Specified Diseases With Participation Of Lymphoreticular And Reticulohistiocytic Tissue Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-CM codes are included in the D76 group?

What clinical scenarios are documented with the D76 code group?

Why is accurate coding within the `D76` group important for reimbursement?

How do related DRGs connect to the D76 code group?

What types of disorders are characterized in the D76 group?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-CM codes are included in the D76 group?

What clinical scenarios are documented with the D76 code group?

Why is accurate coding within the `D76` group important for reimbursement?

How do related DRGs connect to the D76 code group?

What types of disorders are characterized in the D76 group?

References