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    v1.0.28
    OpenPayerBilling CodesOther disorders of blood and blood-forming organsICD-10-CM d74-methemoglobinemia
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    ICD-10-CM Code For Methemoglobinemia: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group D74 includes methemoglobinemia diagnoses, covering inherited enzyme deficiency-related forms and acquired oxidant-induced forms that increase methemoglobin levels and reduce oxygen delivery. These ICD-10-CM diagnosis codes are used to document clinical scenarios such as symptomatic hypoxia with confirmed elevated methemoglobin levels, exposure to oxidizing agents, or congenital cytochrome b5 reductase deficiency, capturing disease severity and treatment complexity. Accurate coding within the ICD-10-CM D74 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM D74: Methemoglobinemia Overview

    The diagnoses in this group represent methemoglobinemia, a disorder involving elevated methemoglobin levels that impair oxygen delivery. These conditions affect the blood and oxygen-carrying capacity, often due to congenital enzyme defects or acquired oxidant exposure. Accurate coding matters for reimbursement because it captures clinical severity and guides appropriate claim processing.

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    When to Use

    Use a code from this group when a patient has clinically significant methemoglobinemia confirmed by laboratory measurement of methemoglobin or when there is documented exposure to agents known to cause methemoglobinemia with corresponding symptoms. Select the appropriate code to reflect whether the cause is congenital or acquired and to capture the severity and any complications.

    ICD-10-CM Codes

    3 rows

    ICD-10-CM CodeDescription
    D74.0Congenital methemoglobinemia
    D74.8Other methemoglobinemias
    D74.9Methemoglobinemia, unspecified

    DRG Codes

    2 rows

    DRG CodeDescription
    811Red Blood Cell Disorders with MCC
    812Red Blood Cell Disorders without MCC

    Typical Clinical Scenarios

    • An adult presents to the emergency department with sudden onset cyanosis, dyspnea, headache, and chocolate-brown colored blood after accidental exposure to high concentrations of topical benzocaine during a dental procedure. Pulse oximetry is low and co-oximetry confirms an elevated methemoglobin level, prompting acute treatment and monitoring; assign a methemoglobinemia code for the toxic acquired presentation. Typical codes: D74.0
    • A newborn in the neonatal unit exhibits poor feeding, grayish discoloration, and hypoxia unresponsive to oxygen; maternal and neonatal history reveal exposure to nitrates in well water and suspected congenital enzyme deficiency. Evaluation identifies persistent elevated methemoglobin, indicating a congenital or neonatal form requiring ongoing management and follow-up; assign a methemoglobinemia code appropriate for a non‑acute neonatal presentation. Typical codes: D74.8, D74.9
    • An adult with chronic anemia and multiple prior transfusions is admitted for elective surgery and perioperative labs reveal elevated methemoglobin as an incidental finding complicating oxygen delivery; the methemoglobinemia is documented as a comorbidity affecting perioperative risk and management. Typical codes: D74.8, D74.9

    Related Codes

    D70-NEUTROPENIA

    ICD-10-CM Code For Neutropenia: Group Overview

    D71-FUNCTIONAL-DISORDERS-OF-POLYMORPHONUCLEAR-NEUTROPHILS

    ICD-10-CM Code For Functional Disorders Of Polymorphonuclear Neutrophils: Group Overview

    D72-OTHER-DISORDERS-OF-WHITE-BLOOD-CELLS

    ICD-10-CM Code For Other Disorders Of White Blood Cells: Group Overview

    D73-DISEASES-OF-SPLEEN

    ICD-10-CM Code For Diseases Of Spleen: Group Overview

    D75-OTHER-AND-UNSPECIFIED-BLOOD-DISORDERS

    ICD-10-CM Code For Other And Unspecified Diseases Of Blood And Blood-Forming Organs: Group Overview

    D76-OTHER-SPECIFIED-LYMPHORETICULAR-DISEASES

    ICD-10-CM Code For Other Specified Diseases With Participation Of Lymphoreticular And Reticulohistiocytic Tissue: Group Overview

    D77-OTHER-DISORDERS-OF-BLOOD

    ICD-10-CM Code For Other Disorders Of Blood And Blood-Forming Organs In Diseases Classified Elsewhere: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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