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    v1.0.30
    OpenPayerBilling CodesImmune Globulins, Serum or Recombinant ProductsCPT cpt-90377-rabies-immunoglobulin-human-high-titer
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    CPT 90377: Human Rabies Immunoglobulin for Passive Immunity

    CPT code 90377 describes human rabies immunoglobulin (RIg) derived from pooled human plasma containing high-titer anti-rabies antibodies, used to provide passive immunity for prevention or treatment of category III rabies exposures; service type is administration of a plasma-derived immunoglobulin product and the typical site of service is an outpatient clinic, emergency department, or other acute care setting where post-exposure prophylaxis or urgent immunotherapy is provided.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a person with a category III potential rabies exposure (e.g., single or multiple transdermal bites or scratches, contamination of mucous membrane with saliva from a rabid or suspect animal). The patient presents to the emergency department, urgent care, or public health clinic within hours of exposure. Clinical workflow: triage assessment of wound and exposure type; wound cleaning and local care; determination of rabies prophylaxis need; administration of rabies immunoglobulin (90377) infiltrated into and around the wound site with any remaining volume given intramuscularly, concurrently with initiation of rabies vaccine series. Documentation includes exposure details (animal type, provoked vs unprovoked), wound description, informed consent, lot numbers and amounts of 90377 administered, concurrent vaccine doses, and patient education and follow-up for vaccine schedule. Typical sites of service are Emergency Department, Urgent Care, Hospital Outpatient Clinic, and Public Health Clinic.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    90471Immunization administration (single)Used to bill administration of a single vaccine dose when rabies vaccine is given concurrently with 90377.
    90472Immunization administration (each additional)Used when multiple vaccine injections are administered during the same visit as 90377.
    99283Emergency department visit, moderate severityCommon E/M level for patients presenting to ED for rabies exposure prior to 90377 administration.
    99401Preventive medicine counseling (short)Used for brief counseling and education about rabies prophylaxis and follow-up (site-dependent).
    36415Collection of venous blood by venipunctureUsed when baseline labs or serology are obtained in association with the exposure evaluation.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    208000000X
    174400000X
    363L00000X
    101YS0200X
    261QM2800X
    313M00000X
    246YC3301X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-90281-IMMUNOGLOBULIN-THERAPY-INFUSION

    CPT 90281: Immunoglobulin for Passive Immunity

    CPT-90283-IMMUNOGLOBULIN-PASSIVE-IMMUNITY

    CPT 90283: Immunoglobulin for Passive Immunity

    CPT-90284-SUBCUTANEOUS-IMMUNOGLOBULIN-INJECTION-SCIG-IGSC

    CPT 90284: Subcutaneous Immunoglobulin (SCIg) Injection

    CPT-90287-BOTULISM-ANTITOXIN-EQUINE-GLOBULIN

    CPT 90287: Botulism Antitoxin (Equine Globulin)

    CPT-90288-BOTULISM-IMMUNE-GLOBULIN-INTRAVENOUS

    CPT 90288: Botulism Immune Globulin Intravenous Administration

    CPT-90291-CMV-IMMUNE-GLOBULIN-INTRAVENOUS-INFUSION

    CPT 90291: Cytomegalovirus Immune Globulin (CMV–IgIV) Administration

    CPT-90296-DIPHTHERIA-ANTITOXIN-EQUINE

    CPT 90296: Diphtheria Antitoxin (Equine) Administration

    CPT-90371-HEPATITIS-B-IMMUNOGLOBULIN-HBIG

    CPT 90371: Hepatitis B Immunoglobulin (HBIg) Injection

    CPT-90375-RABIES-IMMUNOGLOBULIN-PASSIVE-IMMUNITY

    CPT 90375: Human Rabies Immunoglobulin for Passive Immunity

    CPT-90376-RABIES-IMMUNOGLOBULIN-HUMAN-POST-EXPOSURE-PROPHYLAXIS

    CPT 90376: Human Rabies Immunoglobulin for Passive Immunity

    Showing 1–10 of 21

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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